Bio
The Skiniotis laboratory seeks to resolve structural and mechanistic questions underlying biological processes that are central to cellular physiology. Our investigations employ primarily cryo-electron microscopy (cryoEM) and 3D reconstruction techniques complemented by biochemistry, biophysics and simulation methods to obtain a dynamic view into the macromolecular complexes carrying out these processes. The main theme in the lab is the structural biology of cell surface receptors that mediate intracellular signaling and communication. Our current main focus is the exploration of the mechanisms responsible for transmembrane signal instigation in cytokine receptors and G protein coupled receptor (GPCR) complexes.
Academic Appointments
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Professor, Molecular & Cellular Physiology
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Professor, Structural Biology
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Professor, Photon Science Directorate
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Member, Bio-X
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Member, Wu Tsai Neurosciences Institute
Administrative Appointments
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Co-Director of Stanford-SLAC Cryo-EM Center, Stanford University (2017 - Present)
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Professor of Structural Biology and Molecular & Cellular Physiology, Stanford University (2017 - Present)
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Jack E. Dixon Collegiate Professor of the Life Sciences, University of Michigan (2013 - 2017)
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Assistant Professor, Dept. of Biological Chemistry, University of Michigan (2008 - 2013)
Honors & Awards
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Earl and Thressa Stadtman Scholar Award, ASBMB (2016)
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Presidential Early Career Award for Scientists and Engineers, White House/NIH (2012)
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Pew Scholar in Biomedical Sciences, The Pew Charitable Trusts (2011)
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Damon Runyon Cancer Research Foundation postdoctoral fellow, Damon Runyon Cancer Research Foundation (2004)
Boards, Advisory Committees, Professional Organizations
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Scientific Advisory Board member for cryo-EM operations, Harvard Medical School (2018 - Present)