School of Medicine
Showing 21-29 of 29 Results
Associate Professor of Neurosurgery at the Stanford University Medical Center
Current Research and Scholarly Interests My research focuses on screening strategies to identify and characterize cancer stem cells (CSCs) in human gliomas. We are pursuing this in several ways: 1) a novel colony-forming antibody live cell array to identify distinct CSC surface phenotypes, 2) RNAi screens to identify kinases critical for CSC tumorigenicity, 3) high throughput small molecule and chemical screens to identify compounds that selectively kill or target CSCs, and 4) identifying CSCs using the tumor specific EGFRvIII
James R. Doty Professor of Neurosurgery and Neurosciences
Bio Ivan Soltesz received his doctorate in Budapest and conducted postdoctoral research at universities at Oxford, London, Stanford and Dallas. He established his laboratory at the University of California, Irvine, in 1995. He became full Professor in 2003, and served as department Chair from 2006 to July 2015. He returned to Stanford in 2015 as the James R. Doty Professor of Neurosurgery and Neurosciences at Stanford University School of Medicine. His major research interest is focused on neuronal microcircuits, network oscillations, cannabinoid signaling and the mechanistic bases of circuit dysfunction in epilepsy.
His laboratory employs a combination of closely integrated experimental and theoretical techniques, including closed-loop in vivo optogenetics, paired patch clamp recordings, in vivo electrophysiological recordings from identified interneurons in awake mice, 2-photon imaging, machine learning-aided 3D video analysis of behavior, video-EEG recordings, behavioral approaches, and large-scale computational modeling methods using supercomputers. He is the author of a book on GABAergic microcircuits (Diversity in the Neuronal Machine, Oxford University Press), and editor of a book on Computational Neuroscience in Epilepsy (Academic Press/Elsevier). He co-founded the first Gordon Research Conference on the Mechanisms of neuronal synchronization and epilepsy, and taught for five years in the Ion Channels Course at Cold Springs Harbor. He has over 30 years of research experience, with over 20 years as a faculty involved in the training of graduate students (total of 16, 6 of them MD/PhDs) and postdoctoral fellows (20), many of whom received fellowship awards, K99 grants, joined prestigious residency programs and became independent faculty.
Scott G. Soltys, MD
Associate Professor of Radiation Oncology (Radiation Therapy) and, by courtesy, of Neurosurgery at the Stanford University Medical Center
Current Research and Scholarly Interests My clinical and research interests focus on the development of new radiation techniques involving stereotactic radiosurgery and radiotherapy for the treatment of malignant and benign tumors of the brain and spine, as well as functional disorders such as trigeminal neuralgia.
Postdoctoral Research Fellow, Neurosurgery
Current Research and Scholarly Interests I'm trying to restore movement and communication -- and thus, independence -- to people with paralysis. To do so, I'm discovering ways to use neurotechnology to allow people to communicate far more information from their brain to the outside world.
One branch of my brain-computer interface research is to read out complex (high degree-of-freedom) arm movement commands from motor areas of cortex, so that patients can make dextrous movements with, for example, a robotic arm. The goal is to provide enough range of movement that people can perform essential activities of daily living and take care of themselves.
A second branch is to build speech brain-computer interfaces by decoding the neural signals associated with trying to talk. More specifically, I'm trying to reconstruct speech from the movement commands that the brain would normally send to the lips, tongue, jaw, etc. Most work in this space has been using electrocorticography, whereas I'm using electrodes that go into the brain, where we can potentially access more information thanks to the ability to detect individual neurons' action potentials.
My Ph.D. research spanned both fundamental motor neuroscience and applied neural engineering. On the basic science side, I investigated 1) how "internal models" of how the brain's output effects the arm are used by motor cortex. 2) how sensory information carrying information about movement errors is prevented from interfering with motor cortical output until it is "ready" to generate the appropriate output; and 3) how the dynamical rules governing motor cortical activity restrict the kinds of outputs it can generate for the purpose of commanding a neural prosthesis.
My Ph.D. neural engineering work focused on 1) how to robustly decode a user's intended movement despite minute-by-minute and day-to-day changes in neural signals, and 2) sensors' gradually losing the ability to record neuronal action potential. I also studied (3) the effect of ongoing sensory feedback on this signal, and how we can exploit this information to detect and automatically correct for errors.
Gary K. Steinberg, MD, PhD
Bernard and Ronni Lacroute-William Randolph Hearst Professor in Neurosurgery and Neurosciences and Professor, by courtesy, of Neurology
Current Research and Scholarly Interests Our laboratory investigates the pathophysiology and treatment of cerebral ischemia, and methods to restore neurologic function after stroke. Treatment strategies include brain hypothermia, stem cell transplantation and optogenetic stimulation. Our clinical research develops innovative surgical, endovascular and radiosurgical approaches for treating difficult intracranial aneurysms, complex vascular malformations and occlusive disease, including Moyamoya disease, as well as stem cell transplant.
Martin Nikolaus Stienen
Clinical Instructor, Neurosurgery
Bio Dr. Stienen obtained his medical degree at the Ruhr-University Bochum (Germany), where he also earned his doctoral degree (MD) with highest honors (Summa Cum Laude) for experimental studies dealing with the conductivity of potassium channels of glial cells. He undertook his neurosurgical training at the Cantonal Hospital St.Gallen, and at the University Hospitals of Geneva and Zürich (Switzerland). Dr. Stienen has obtained the Swiss board certification for Neurosurgery (FMH) in 01/2018, and was nominated ?Fellow of the European Board of Neurological Surgeons? (FEBNS) in 03/2018. He has been appointed consultant neurosurgeon at the University Hospital Zürich in 01/2018 and has achieved the rank of a private docent (venia legendi) at the University of Zürich with a habilitation thesis on ?The Assessment of Complications and Outcomes in Modern Neurosurgical Patient Care?.
Dr. Stienen?s primary interest is caring for patients, and he is constantly motivated to bring out the best by seeing them recover well and getting back to their daily lives. Besides the clinical work, he has long-standing interest in research, focusing mainly on the three topics 1) Subjective and objective outcome assessment of patients with diseases of the spine, 2) Multi-dimensional assessment of patients after aneurysmal subarachnoid hemorrhage and 3) Training and education in Neurosurgery. Dr. Stienen has conducted studies and led research groups. He has published extensively in those fields, and is frequently invited as reviewer for international highly ranked academic journals.
As Clinical Instructor at Stanford, Dr. Stienen is currently concentrating on the treatment of complex diseases of the spine (Complex Spine Fellowship). After this, he will travel to South Korea for an additional spine fellowship, having been awarded with a travel grant from the Swiss Society of Neurosurgery. He will then continue to pursue a clinical academic career in neurosurgery as attending neurosurgeon at the University Hospital Zürich.