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  • David Solow-Cordero

    David Solow-Cordero

    Director, HTBC, Chemical and Systems Biology Operations

    Current Role at Stanford Director, High-Throughput Bioscience Center

    The High-Throughput Bioscience Center's mission is to provide researchers at Stanford with the ability to run high-throughput chemical, siRNA, cDNA, and high-content screens for the purpose of drug and/or target discovery. The HTBC is a Stanford University School of Medicine core facility and was created in 2003 by the Department of Chemical and Systems Biology (formerly Molecular Pharmacology). The HTBC is a shared resource (Bioscience Screening Facility) for the Stanford Cancer Institute.

    This high-throughput screening (HTS) laboratory allows Stanford researchers and others to discover novel modulators of targets that otherwise would not be practical in industry. The center incorporates instrumentation (purchased with NCRR NIH Instrumentation grant numbers S10RR019513, S10RR026338, S10OD025004, and S10OD026899), databases , compound libraries , and personnel whose previous sole domains were in industry.

    Among our instrumentation are a fully automated Molecular Devices ImageXpress Micro Confocal High-Content fluorescence microplate imager, with live cell, fluidics and phase contrast options, a Union Biometrica Biosorter large object sorter, a Caliper Life Sciences SciClone ALH3000 and an Agilent Bravo microplate liquid handler, and the Tecan Infinite M1000 and M1000 PRO and Molecular Devices Analyst GT and FlexStation II 384 fluorescence, luminescence and absorbance multimode microplate readers.

    We have over 130,000 small molecules for compound screens, 15,000 cDNAs for genomic screens, and whole genome siRNA libraries targeting the human genome (the siARRAY whole human genome siRNA library from Dharmacon, targeting 21,000 human genes) and the mouse genome (Qiagen mouse whole genome siRNA set V1 against 22,124 genes).

    The HTBC is located in CCSR Room 0133-North Wing, between the Transgenic Mouse Facility, and the Stanford Functional Genomics Facility.

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