School of Medicine
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David E. Solow-Cordero
Director, HTBC, Chemical and Systems Biology Operations
Current Role at Stanford Director, High-Throughput Bioscience Center
The High-Throughput Bioscience Center's mission is to provide researchers at Stanford with the ability to run high-throughput chemical, siRNA, cDNA, and high-content screens for the purpose of drug and/or target discovery. The HTBC is a Stanford University School of Medicine core facility and was created in 2003 by the Department of Chemical and Systems Biology (formerly Molecular Pharmacology). The HTBC is a shared resource (Bioscience Screening Facility) for the Stanford Cancer Institute (more info), the Digestive Disease Center (Chemical Genomics Core), and the NIH Clinical and Translational Science Award (Spectrum).
Research approaches that were previously done exclusively in industry are now being used in academia to advance basic research. This high-throughput screening (HTS) laboratory allows Stanford researchers and others to discover novel modulators of targets that otherwise would not be practical in industry. The center incorporates instrumentation (purchased with NCRR NIH Instrumentation grant numbers S10RR019513 and S10RR026338), databases, compound libraries, and personnel whose previous sole domains were in industry. Among our instrumentation are a Molecular Devices ImageXpress Micro High-Content fluorescence microplate imager, with live cell and phase contrast/brightfield options, a Caliper Life Sciences SciClone ALH3000 and an Agilent Bravo microplate liquid handler, and the Molecular Devices Analyst GT and FlexStation II 384 and Tecan Infinite M1000 PRO fluorescence, luminescence and absorbance multimode microplate readers. We have over 135,000 small molecules for compound screens, 15,000 cDNAs for genomic screens, and the siARRAY whole human genome siRNA library from ThermoFisher Scientific (formerly Dharmacon) targeting 21,000 genes.
The HTBC is located in CCSR Room 0133-North Wing, between the Transgenic Mouse Facility, the Immune Monitoring Core, and the Stanford Functional Genomics Facility.
Basic Life Science Research Associate, Stanford Cancer Institute
Bio I am a bioinformatician and geneticist specializing in data-driven modelling and computational algorithms for massive parallel sequencing data. I work in Dr. Curtis lab in Stanford Cancer Institute, where I serve as a staff member, conducting computational cancer research by analyzing and interpreting genomic and transcriptomic heterogeneity in multi-regional, longitudinal or single-cell sampling of human cancers. Under the direction of Dr. Curtis, I also collaborate with some other labs for studying the genetics of a rare pediatric cancer type and non-coding gene regulation. Before joining Stanford, I worked at Columbia in NYC and Max Planck Institute for Molecular Genetics in Berlin, where I did extensive research on models for gene regulation and algorithm design for next generation sequencing data. My goal is to further my discovery of connections between high resolution (epi)genetic information and cancer aetiology and progression. I also aim to popularize algorithm development and data visualization for better extracting and interpreting the (epi)genetic alterations.