School of Medicine
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Clinical Instructor, Medicine - Cardiovascular Medicine
Bio Dr. Parikh is cardiologist specializing in the care of patients with inherited cardiovascular diseases. She completed clinical cardiology fellowship at Stanford School of Medicine and her medical residency at the University of California, San Francisco. Funded by research grant from the NIH, she currently studies multiple causes of cardiomyopathy in the laboratory. She has a particular clinical and scientific interest in inherited arrhythmogenic cardiomyopathies, which are an increasingly recognized disease entity. Dr. Parikh is currently using patient cohort genetics, high throughput molecular biology and human induced pluripotent stem cell derived cardiomyocytes to study variant pathogenicity in this disease.
Postdoctoral Research Fellow, Cardiovascular Medicine
Bio Research statement:
My major fields of interest are computational biology and bioinformatics, coupled with the passion for the next-generation sequencing technologies, and a profound scientific interest in genomics, transcriptomics, regulation of gene expression, specificity of binding of transcription factors to the genome, histone modifications, nucleosome positioning, long-range genomic interactions and compartmentalization of the genome. My research lies on the frontier of the contemporary computational genomics, with the emphasis on development and testing of scripts and algorithms for the analysis of human genome and transcriptome. My focus is the improvement of methods for the various applications of the next generation sequencing, such as chromatin - immunoprecipitation sequencing or ChIP-Seq, RNA-sequencing or RNA-Seq, and probing open chromatin, DNase-Seq/ATAC-Seq, in order to answer key biological question that will ultimately help us understand better the underlying mechanisms of life. As a postdoc at Stanford?s Cardiovascular Institute, I am elucidating complex networks of interactions of transcription factors in human cardiac and vascular tissues, and molecular mechanisms that explain how cardiovascular disease risk-associated genomic loci confer disease risk. I am also employing allele specific computational pipelines to the existing next generation sequencing techniques, i.e. ChIP-Seq and RNA-Seq, in combination with the generation of eQTL data for human arterial smooth muscle cells (primary cell type of atherosclerotic lesions) to identify the causal variants that underlie disease susceptibility. In addition, I am modeling vascular SMC tissue-specific open chromatin with ATAC-Seq and DNase-Seq to understand the underlying mechanisms for cardiovascular disease causal variants. I am also active as a blogger, started a blog www.genomicscode.org and continually post UNIX and R related tips and resolve computational problems that can be applied to genomics.