School of Medicine

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  • Fang Chen (Rosy)

    Fang Chen (Rosy)

    Postdoctoral Research Fellow, Ophthalmology

    Current Research and Scholarly Interests Corneal regeneration via hydrogel-based cell scaffold and cell encapsulation

  • Wei Chen

    Wei Chen

    Postdoctoral Research Fellow, Ophthalmology

    Bio My long-term goals involve the development of a full understanding of key molecular mechanisms and the identification of corresponding therapeutics for human diseases. My research training and academic experience have provided me with an excellent background necessary in multiple fields including molecular biology, cell biology, medicinal chemistry, and biochemical pharmacology. As an undergraduate, I have learned numerous biology and physiology courses, which let me appreciate and understand biological diversity. As a predoctoral student, my research focused on the identification and evaluation of fusion proteins, gene therapy-based biologics, molecular modifiers and inhibitors to treat tissue injury or cancer. We first revealed a novel mechanism underscoring the regulation of metabolic profiles and mitochondrial function of epithelial cells by IL-22 during cell injury, which might provide useful insights from the bench to the clinic in treating and preventing more diseases, especially acute stroke/traumatic brain injuries. We subsequently demonstrated that autophagy was induced to play cytoprotective roles in numerous cells, which highlighted the potential therapeutic strategies for CNS neurodegeneration diseases or cancer by targeting autophagy. During my undergraduate and graduate careers, I also received several academic awards, including two times National Scholarship. For my postdoctoral training, I will continue to build on my previous researches in metabolic profiles and mitochondrial function regulations by concentrating on determining the role of mitochondrial thioredoxin metabolism in neuronal survival. These new scientific issues will allow me to address additional problems regarding the molecular basis of neurodegeneration and develop a neuroprotective gene therapy strategy to protect CNS neurodegenerative diseases/injuries.

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