School of Medicine

Showing 11-20 of 91 Results

  • Jennifer Caswell-Jin

    Jennifer Caswell-Jin

    Postdoctoral Medical Fellow, Oncology

    Current Research and Scholarly Interests My research is on the translational application of next-generation sequencing technologies to breast cancer care: (1) the value of hereditary cancer genetic panel testing in clinical practice, (2) the mechanisms by which inherited genetic variants lead to breast cancer development, and (3) the analysis of somatic tumor sequencing data to inform understanding of breast tumorigenesis, metastasis, and development of resistance in response to therapeutics.

  • Joshua Cates

    Joshua Cates

    Postdoctoral Research Fellow, Radiology

    Current Research and Scholarly Interests Joshua's research focus at Stanford has been enabling technologies and instrumentation for future and vital roles of Positron Emission Tomography (PET), including: Ultra-fast Time-of-Flight PET (TOF-PET) instrumentation, clinical PET detector technology with high sensitivity and resolving power for diagnostics in early stage cancer, high resolution MRI-compatible TOF-PET detector technologies for oncology and neurology, and devices for precise quantification of tracer kinetics in dynamic PET imaging. The ultimate goal is to introduce new PET imaging systems that advance capabilities of whole body clinical imaging in sensitivity, accuracy, and precision for oncology, neurology, and cardiology.

    He is also interested in the application of instrumentation and algorithms for imaging in biomedical, high energy and applied physics, astronomy, energy, materials, nuclear security, and autonomous vehicle research.

  • Harini Chakravarthy

    Harini Chakravarthy

    Postdoctoral Research Fellow, Developmental Biology

    Current Research and Scholarly Interests The discovery that insulin-producing ?-cells can be generated from cell sources within and outside the pancreas is of fundamental importance in terms of developing novel treatment strategies for diabetes. A major caveat to this is our relatively poor understanding of the players involved in this process and the lack of molecular characterization of the ?converted? ?-cells. This knowledge is key to our success in enhancing this process to its maximum therapeutic potential and efficiency. In this context, recent work has shown that ?-cells can be used as a source to generate ?-cells under conditions of near-total ?-cell depletion in mice. However the molecular mechanisms regulating ?-cell identity are unknown. This knowledge would allow us to harness the potential of ?-cells to give rise to ?-cells in diabetic patients where pancreatic ?-cells tend to be in abundant supply within the pancreas. My work in the laboratory has elucidated the role of two genes in maintaining ?-cell identity: Dnmt1 and Arx. Dnmt1, a DNA methyltransferase methylates DNA and is involved in gene repression. Arx is a transcription factor that is essential for ?-cell specification during embryogenesis. My work demonstrates that conditional in vivo inactivation of Dnmt1 and Arx in adult ?-cells causes them to convert into insulin producing ?-like-cells demonstrating the necessity of these two factors in maintaining ?-cell fate. Further functional characterization of these ?converted? cells will elucidate the extent to which ?-to- ?-cell conversion has occurred in these animals. I am also assessing the individual contributions of Dnmt1 and Arx in maintaining adult ?-cell identity.

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