Doctor of Philosophy, Ruprecht Karl Universitat Heidelberg (2017)
Master of Science, Ruprecht Karl Universitat Heidelberg (2012)
Bachelor of Medicine, Peking University (2009)
View details for Web of Science ID 000459610400452
Translationally controlled tumor protein (TCTP) is a highly conserved protein functioning in multiple cellular processes, ranging from growth to immune responses. To explore the role of TCTP in tissue maintenance and regeneration, we employed the adult Drosophila midgut, where multiple signaling pathways interact to precisely regulate stem cell division for tissue homeostasis. Tctp levels were significantly increased in stem cells and enteroblasts upon tissue damage or activation of the Hippo pathway that promotes regeneration of intestinal epithelium. Stem cells with reduced Tctp levels failed to proliferate during normal tissue homeostasis and regeneration. Mechanistically, Tctp forms a complex with multiple proteins involved in translation and genetically interacts with ribosomal subunits. In addition, Tctp increases both Akt1 protein abundance and phosphorylation in vivo. Altogether, Tctp regulates stem cell proliferation by interacting with key growth regulatory signaling pathways and the translation process in vivo.
View details for DOI 10.1073/pnas.1910850116
View details for PubMedID 31843907
View details for PubMedCentralID PMC6936429