Bio

Clinical Focus


  • Internal Medicine

Academic Appointments


Professional Education


  • Residency, University of Chicago (NorthShore), Internal Medicine
  • Medical Education, University of Chicago Pritzker School of Medicine, MD (2015)
  • B.S., Stanford University, Biological Sciences

Publications

All Publications


  • Evidence for Clinical Implementation of Pharmacogenomics in Cardiac Drugs MAYO CLINIC PROCEEDINGS Kaufman, A. L., Spitz, J., Jacobs, M., Sorrentino, M., Yuen, S., Danahey, K., Saner, D., Klein, T. E., Altman, R. B., Ratain, M. J., O'Donnell, P. H. 2015; 90 (6): 716-729

    Abstract

    To comprehensively assess the pharmacogenomic evidence of routinely used drugs for clinical utility.Between January 2, 2011, and May 31, 2013, we assessed 71 drugs by identifying all drug/genetic variant combinations with published clinical pharmacogenomic evidence. Literature supporting each drug/variant pair was assessed for study design and methods, outcomes, statistical significance, and clinical relevance. Proposed clinical summaries were formally scored using a modified AGREE (Appraisal of Guidelines for Research and Evaluation) II instrument, including recommendation for or against guideline implementation.Positive pharmacogenomic findings were identified for 51 of 71 cardiovascular drugs (71.8%), representing 884 unique drug/variant pairs from 597 publications. After analysis for quality and clinical relevance, 92 drug/variant pairs were proposed for translation into clinical summaries, encompassing 23 drugs (32.4% of drugs reviewed). All were recommended for clinical implementation using AGREE II, with mean SD overall quality scores of 5.180.91 (of 7.0; range, 3.67-7.0). Drug guidelines had highest mean SD scores in AGREE II domain 1 (Scope) (91.96.1 of 100) and moderate but still robust mean SD scores in domain 3 (Rigor) (73.111.1), domain 4 (Clarity) (67.812.5), and domain 5 (Applicability) (65.810.0). Clopidogrel (CYP2C19), metoprolol (CYP2D6), simvastatin (rs4149056), dabigatran (rs2244613), hydralazine (rs1799983, rs1799998), and warfarin (CYP2C9/VKORC1) were distinguished by the highest scores. Seven of the 9 most commonly prescribed drugs warranted translation guidelines summarizing clinical pharmacogenomic information.Considerable clinically actionable pharmacogenomic information for cardiovascular drugs exists, supporting the idea that consideration of such information when prescribing is warranted.

    View details for DOI 10.1016/j.mayocp.2015.03.016

    View details for Web of Science ID 000355557900008

    View details for PubMedID 26046407

    View details for PubMedCentralID PMC4475352

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