Bio

Current Role at Stanford


Scientific Education and Outreach Program Coordinator

Supervisors


Education & Certifications


  • PhD, University of Washington, Neurobiology & Behavior (2013)
  • MSc, Imperial College London, Computer Science (2006)
  • BSc, Imperial College London, Biology (2005)

Publications

All Publications


  • Linking ADHD to the Neural Circuitry of Attention TRENDS IN COGNITIVE SCIENCES Mueller, A., Hong, D. S., Shepard, S., Moore, T. 2017; 21 (6): 474-488

    Abstract

    Attention deficit hyperactivity disorder (ADHD) is a complex condition with a heterogeneous presentation. Current diagnosis is primarily based on subjective experience and observer reports of behavioral symptoms - an approach that has significant limitations. Many studies show that individuals with ADHD exhibit poorer performance on cognitive tasks than neurotypical controls, and at least seven main functional domains appear to be implicated in ADHD. We discuss the underlying neural mechanisms of cognitive functions associated with ADHD, with emphasis on the neural basis of selective attention, demonstrating the feasibility of basic research approaches for further understanding cognitive behavioral processes as they relate to human psychopathology. The study of circuit-level mechanisms underlying executive functions in nonhuman primates holds promise for advancing our understanding, and ultimately the treatment, of ADHD.

    View details for DOI 10.1016/j.tics.2017.03.009

    View details for PubMedID 28483638

  • Dopamine Receptor Expression Among Local and Visual Cortex-Projecting Frontal Eye Field Neurons CEREBRAL CORTEX Mueller, A., Krock, R. M., Shepard, S., Moore, T. 2020; 30 (1): 148?64
  • Prefrontal Contributions to Attention and Working Memory. Current topics in behavioral neurosciences Bahmani, Z., Clark, K., Merrikhi, Y., Mueller, A., Pettine, W., Isabel Vanegas, M., Moore, T., Noudoost, B. 2019

    Abstract

    The processes of attention and working memory are conspicuously interlinked, suggesting that they may involve overlapping neural mechanisms. Working memory (WM) is the ability to maintain information in the absence of sensory input. Attention is the process by which a specific target is selected for further processing, and neural resources directed toward that target. The content of WM can be used to direct attention, and attention can in turn determine which information is encoded into WM. Here we discuss the similarities between attention and WM and the role prefrontal cortex (PFC) plays in each. First, at the theoretical level, we describe how attention and WM can both rely on models based on attractor states. Then we review the evidence for an overlap between the areas involved in both functions, especially the frontal eye field (FEF) portion of the prefrontal cortex. We also discuss similarities between the neural changes in visual areas observed during attention and WM. At the cellular level, we review the literature on the role of prefrontal DA in both attention and WM at the behavioral and neural levels. Finally, we summarize the anatomical evidence for an overlap between prefrontal mechanisms involved in attention and WM. Altogether, a summary of pharmacological, electrophysiological, behavioral, and anatomical evidence for a contribution of the FEF part of prefrontal cortex to attention and WM is provided.

    View details for PubMedID 30739308

  • Differential Expression of Dopamine D5 Receptors across Neuronal Subtypes in Macaque Frontal Eye Field FRONTIERS IN NEURAL CIRCUITS Mueller, A., Shepard, S. B., Moore, T. 2018; 12: 12

    Abstract

    Dopamine signaling in the prefrontal cortex (PFC) is important for cognitive functions, yet very little is known about the expression of the D5 class of dopamine receptors (D5Rs) in this region. To address this, we co-stained for D5Rs, pyramidal neurons (neurogranin+), putative long-range projection pyramidal neurons (SMI-32+), and several classes of inhibitory interneuron (parvalbumin+, calbindin+, calretinin+, somatostatin+) within the frontal eye field (FEF): an area within the PFC involved in the control of visual spatial attention. We then quantified the co-expression of D5Rs with markers of different cell types across different layers of the FEF. We show that: (1) D5Rs are more prevalent on pyramidal neurons than on inhibitory interneurons. (2) D5Rs are disproportionately expressed on putative long-range projecting pyramidal neurons. The disproportionately high expression of D5Rs on long-range projecting pyramidals, compared to interneurons, was particularly pronounced in layers II-III. Together these results indicate that the engagement of D5R-dependent mechanisms in the FEF varies depending on cell type and cortical layer, and suggests that non-locally projecting neurons contribute disproportionately to functions involving the D5R subtype.

    View details for PubMedID 29483863

  • Distribution of N-Acetylgalactosamine-Positive Perineuronal Nets in the Macaque Brain: Anatomy and Implications. Neural plasticity Mueller, A. L., Davis, A., Sovich, S., Carlson, S. S., Robinson, F. R. 2016; 2016: 6021428

    Abstract

    Perineuronal nets (PNNs) are extracellular molecules that form around neurons near the end of critical periods during development. They surround neuronal cell bodies and proximal dendrites. PNNs inhibit the formation of new connections and may concentrate around rapidly firing inhibitory interneurons. Previous work characterized the important role of perineuronal nets in plasticity in the visual system, amygdala, and spinal cord of rats. In this study, we use immunohistochemistry to survey the distribution of perineuronal nets in representative areas of the primate brain. We also document changes in PNN prevalence in these areas in animals of different ages. We found that PNNs are most prevalent in the cerebellar nuclei, surrounding >90% of the neurons there. They are much less prevalent in cerebral cortex, surrounding less than 10% of neurons in every area that we examined. The incidence of perineuronal nets around parvalbumin-positive neurons (putative fast-spiking interneurons) varies considerably between different areas in the brain. Our survey indicates that the presence of PNNs may not have a simple relationship with neural plasticity and may serve multiple functions in the central nervous system.

    View details for DOI 10.1155/2016/6021428

    View details for PubMedID 26881119

    View details for PubMedCentralID PMC4735937

  • N-acetylgalactosamine positive perineuronal nets in the saccade-related-part of the cerebellar fastigial nucleus do not maintain saccade gain. PloS one Mueller, A., Davis, A., Carlson, S. S., Robinson, F. R. 2014; 9 (3): e86154

    Abstract

    Perineuronal nets (PNNs) accumulate around neurons near the end of developmental critical periods. PNNs are structures of the extracellular matrix which surround synaptic contacts and contain chondroitin sulfate proteoglycans. Previous studies suggest that the chondroitin sulfate chains of PNNs inhibit synaptic plasticity and thereby help end critical periods. PNNs surround a high proportion of neurons in the cerebellar nuclei. These PNNs form during approximately the same time that movements achieve normal accuracy. It is possible that PNNs in the cerebellar nuclei inhibit plasticity to maintain the synaptic organization that produces those accurate movements. We tested whether or not PNNs in a saccade-related part of the cerebellar nuclei maintain accurate saccade size by digesting a part of them in an adult monkey performing a task that changes saccade size (long term saccade adaptation). We use the enzyme Chondroitinase ABC to digest the glycosaminoglycan side chains of proteoglycans present in the majority of PNNs. We show that this manipulation does not result in faster, larger, or more persistent adaptation. Our result indicates that intact perineuronal nets around saccade-related neurons in the cerebellar nuclei are not important for maintaining long-term saccade gain.

    View details for DOI 10.1371/journal.pone.0086154

    View details for PubMedID 24603437

    View details for PubMedCentralID PMC3945643

  • Sources of tonic firing properties of saccade-related cerebellar neurons Mueller, A., Robinson, R. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2013
  • When during horizontal saccades in monkey does cerebellar output affect movement? Brain research Buzunov, E., Mueller, A., Straube, A., Robinson, F. R. 2013; 1503: 33?42

    Abstract

    The caudal part of the cerebellar fastigial nucleus (CFN) influences the horizontal component of saccades. Previous reports show that activity in the CFN contralateral to saccade direction aids saccade acceleration and that activity in the ipsilateral CFN aids saccade deceleration. Here we refine this description by characterizing how blocking CFN activity changes the distance that the eye rotates during each of 4 phases of saccades, the increasing and decreasing saccade acceleration (phases 1 and 2) and deceleration (3 and 4). We found that unilateral CFN inactivation increases total eye rotation to ?1.8 normal. This resulted from rotation increases in all four phases of ipsiversive saccades. Rotation during phases 1 and 2 increases slightly, more during phase 3, and most during phase 4, to ?4.4 normal. Thus, the ipsilateral CFN normally reduces eye rotation throughout a saccade but reduces it the most near saccade end. After unilateral CFN inactivation, rotation during contraversive saccades was ?0.8 normal. This resulted from decreased rotation during phases 1-3, to ?0.7 normal, and then normal rotation during phase 4. Thus the CFN contraversive to saccade direction normally increases eye rotation during acceleration and the first phase of deceleration. These data indicate that the influences of the CFNs on saccades overlap extensively and that there is a smooth shift from predominance of the contralateral CFN early in a saccade to the ipsilateral CFN later. The pathway from the CFN to contralateral IBNs and then to the abducens nucleus can account for these effects.

    View details for DOI 10.1016/j.brainres.2013.02.001

    View details for PubMedID 23399683

    View details for PubMedCentralID PMC4556436

  • Long-term size-increasing adaptation of saccades in macaques. Neuroscience Mueller, A. L., Davis, A. J., Robinson, F. R. 2012; 224: 38?47

    Abstract

    Motor learning adjusts movement size and direction to keep movements accurate. A useful model of motor learning, saccade adaptation, uses intra-saccade target movement to make saccades seem inaccurate and elicit adaptive changes in saccades. In the most studied saccade adaptation procedure, which we call short-term saccade adaptation (STSA), monkeys decrease or increase the size of their saccades by tracking 1000-2000 adapting target movements in a single saccade session. STSA elicits rapid changes of limited size and duration. Larger, more persistent reduction in saccade size results from adapting saccades daily for 19 days, a procedure that we call long-term saccade adaptation (LTSA). LTSA mimics the demands of rehabilitation more closely than does STSA and, unlike STSA, produces changes that could maintain long-term accuracy. Previous work describes LTSA that reduces saccade size in monkeys. Though convenient to study, size-decreasing LTSA is not a good model for rehabilitation because few injuries necessitate making movements smaller. Here we characterize size-increasing LTSA and compare it, in the same monkeys, to size-reducing LTSA. We found that size-increasing LTSA can double saccade gain in ?21 days, and is slower than size-decreasing LTSA. In contrast to a single size-decreasing STSA, a single size-increasing STSA does not prevent additional saccade size increase at the normal rate when a monkey continues to track adapting target movements. We conclude that size-increasing LTSA is slower than size-decreasing LTSA but can make larger changes in saccade size. Size-increasing and size-decreasing LTSA use distinct mechanisms with different performance characteristics.

    View details for DOI 10.1016/j.neuroscience.2012.08.012

    View details for PubMedID 22902543

    View details for PubMedCentralID PMC3468708

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