Bio

Bio


With my background in medicine, microdevice engineering, and nanotechnology, my strengths lie in developing novel solutions to urgent problems in medicine and cancer research. Having developed a diagnostic microfluidic device at Caltech and initiated a clinical trial to test the device on glioblastoma patients at UCLA, I’m particlularly interested in moving promising technologies past the proof-of-concept phase and into the clinic. My career goals are to continue to work at the interface of medicine and technology as an academic scientist, engineering new wearable and implantable technologies for earlier cancer detection and continuous monitoring.

Honors & Awards


  • Advanced Placement Scholar with Honor, The College Board (1996)
  • Advanced Placement Scholar with Distinction, The College Board (1997)
  • Departmental Honors, Stanford Chemistry, Stanford (2002)
  • NSF Graduate Fellowship Honorable Mention, NSF (2004)
  • NIH Medical Scientist Training Program, UCLA (2004-2012)
  • Letter of Distinction: UCLA GI, Endocrine, and Reproductive Health II Bloc, UCLA (2006)
  • Caltech Graduate Research Assistantship, Caltech (2006-2010)
  • Lemelson-MIT Caltech Invention Prize, Caltech, MIT, and Lemelson Program (2009)
  • The Gerald S. Levey, M.D., Medical Science Scholarship, UCLA (2011)

Boards, Advisory Committees, Professional Organizations


  • Vice-President, American Medical Association, UCLA Chapter (2004 - 2005)
  • President, American Medical Association, UCLA Chapter (2005 - 2006)

Professional Education


  • Doctor of Medicine, University of California Los Angeles (2012)
  • Bachelor of Science, Stanford University, MATH-BS (2002)
  • Bachelor of Science, Stanford University, CHEM-BSH (2002)
  • Master of Science, Stanford University, CHEME-MS (2002)
  • Doctor of Philosophy, California Institute of Technology (2011)

Stanford Advisors


Patents


  • Ophir Vermesh, Brian KH Yen, James R. Heath. "United StatesMicrofluidic Devices, Methods and Systems for Detecting Target Molecules.", California Institute of Technology

Research & Scholarship

Current Research and Scholarly Interests


My interests lie at the interface of medicine and technology, engineering new wearable and implantable technologies for earlier cancer detection and continuous monitoring. I am particularly interested in moving promising diagnostic technologies past the proof-of-concept phase and into the clinic.

Lab Affiliations


Publications

Journal Articles


  • High-Density, Multiplexed Patterning of Cells at Single-Cell Resolution for Tissue Engineering and Other Applications ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Vermesh, U., Vermesh, O., Wang, J., Kwong, G. A., Ma, C., Hwang, K., Heath, J. R. 2011; 50 (32): 7378-7380

    View details for DOI 10.1002/anie.201102249

    View details for Web of Science ID 000293840400033

    View details for PubMedID 21717543

  • A self-powered, one-step chip for rapid, quantitative and multiplexed detection of proteins from pinpricks of whole blood LAB ON A CHIP Wang, J., Ahmad, H., Ma, C., Shi, Q., Vermesh, O., Vermesh, U., Heath, J. 2010; 10 (22): 3157-3162

    Abstract

    We describe an automated, self-powered chip based on lateral flow immunoassay for rapid, quantitative, and multiplex protein detection from pinpricks of whole blood. The device incorporates on-chip purification of blood plasma by employing inertial forces to focus blood cells away from the assay surface, where plasma proteins are captured and detected on antibody "barcode" arrays. Power is supplied from the capillary action of a piece of adsorbent paper, and sequentially drives, over a 40 minute period, the four steps required to capture serum proteins and then develop a multiplex immunoassay. An 11 protein panel is assayed from whole blood, with high sensitivity and high reproducibility. This inexpensive, self-contained, and easy to operate chip provides a useful platform for point-of-care diagnoses, particularly in resource-limited settings.

    View details for DOI 10.1039/c0lc00132e

    View details for Web of Science ID 000283600900017

    View details for PubMedID 20924527

  • Fast Nonlinear Ion Transport via Field-induced Hydrodynamic Slip in Sub-20-nm Hydrophilic Nanofluidic Transistors NANO LETTERS Vermesh, U., Choi, J. W., Vermesh, O., Fan, R., Nagarah, J., Heath, J. R. 2009; 9 (4): 1315-1319

    Abstract

    Electrolyte transport through an array of 20 nm wide, 20 microm long SiO(2) nanofluidic transistors is described. At sufficiently low ionic strength, the Debye screening length exceeds the channel width, and ion transport is limited by the negatively charged channel surfaces. At source-drain biases >5 V, the current exhibits a sharp, nonlinear increase, with a 20-50-fold conductance enhancement. This behavior is attributed to a breakdown of the zero-slip condition. Implications for energy conversion devices are discussed.

    View details for DOI 10.1021/nl802931r

    View details for Web of Science ID 000265030000006

    View details for PubMedID 19265427

  • Self-powered microfluidic chips for multiplexed protein assays from whole blood LAB ON A CHIP Qin, L., Vermesh, O., Shi, Q., Heath, J. R. 2009; 9 (14): 2016-2020

    Abstract

    We report herein on a self-powered, self-contained microfluidic-based chip designed to separate plasma from whole blood, and then execute an assay of a multiplexed panel of plasma biomarker proteins. The power source is based upon a chemical reaction that is catalytically triggered by the push of a button on the chip. We demonstrate assays of a dozen blood-based protein biomarkers using this automated, self-contained device. This platform can potentially permit high throughput, accurate, multiplexed blood diagnostic measurements in remote locations and by minimally trained individuals.

    View details for DOI 10.1039/b821247c

    View details for Web of Science ID 000267572000008

    View details for PubMedID 19568669

  • Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood NATURE BIOTECHNOLOGY Fan, R., Vermesh, O., Srivastava, A., Yen, B. K., Qin, L., Ahmad, H., Kwong, G. A., Liu, C., Gould, J., Hood, L., Heath, J. R. 2008; 26 (12): 1373-1378

    Abstract

    As the tissue that contains the largest representation of the human proteome, blood is the most important fluid for clinical diagnostics. However, although changes of plasma protein profiles reflect physiological or pathological conditions associated with many human diseases, only a handful of plasma proteins are routinely used in clinical tests. Reasons for this include the intrinsic complexity of the plasma proteome, the heterogeneity of human diseases and the rapid degradation of proteins in sampled blood. We report an integrated microfluidic system, the integrated blood barcode chip that can sensitively sample a large panel of protein biomarkers over broad concentration ranges and within 10 min of sample collection. It enables on-chip blood separation and rapid measurement of a panel of plasma proteins from quantities of whole blood as small as those obtained by a finger prick. Our device holds potential for inexpensive, noninvasive and informative clinical diagnoses, particularly in point-of-care settings.

    View details for DOI 10.1038/nbt.1507

    View details for Web of Science ID 000261591300023

    View details for PubMedID 19029914

  • Toward large arrays of multiplex functionalized carbon nanotube sensors for highly sensitive and selective molecular detection NANO LETTERS Pengfei, Q. F., Vermesh, O., Grecu, M., Javey, A., Wang, O., Dai, H. J., Peng, S., Cho, K. J. 2003; 3 (3): 347-351

    View details for DOI 10.1021/nl034010k

    View details for Web of Science ID 000181586600015

  • Hysteresis caused by water molecules in carbon nanotube field-effect transistors NANO LETTERS Kim, W., Javey, A., Vermesh, O., Wang, O., Li, Y. M., DAI, H. J. 2003; 3 (2): 193-198

    View details for DOI 10.1021/nl0259232

    View details for Web of Science ID 000181001500018

Presentations


  • "The Integrated Blood Barcode Chip." UCLA-Caltech MSTP 2009 Annual Research Conference. University of California, Los Angeles. September 11, 2009.

    Time Period

    September 11, 2009

    Location

    University of California, Los Angeles

  • "The Integrated Blood Barcode Chip." Lemelson-MIT Eurekafest 2009, Massachusettes Institute of Technology, Cambridge, MA. June 25, 2009.

    Location

    Cambridge, MA

  • "The Integrated Blood Barcode Chip." 237th ACS National Meeting & Exposition, Salt Lake City, UT. March 26, 2009.

    Location

    Salt Lake City, UT

  • "The Integrated Blood Barcode Chip." Materials Research Society Spring 2009 Meeting, San Francisco, CA, April 16, 2009.

    Location

    San Francisco, CA

  • "The Integrated Blood Barcode Chip." Lemelson-Caltech Student Prize Ceremony, Caltech, Pasadena, CA. March 5, 2009.

    Location

    Pasadena, CA

  • The "Integrated Blood Barcode Chip." Nanosystems Biology Cancer Center (NSBCC) Annual Retreat, Ventura, CA, April 3, 2009.

    Location

    Ventura, CA

  • "Integrated On-Chip Blood Separation and Detection." Nanosystems Biology Cancer Center (NSBCC) Annual Retreat, Ventura, CA, February 15, 2008.

    Location

    Ventura, CA

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