Onn Brandman

Associate Professor of Biochemistry and, by courtesy, of Chemical and Systems Biology

Academic Appointments

Associate Professor, Biochemistry
Associate Professor (By courtesy), Chemical and Systems Biology
Member, Bio-X
Member, Stanford Cancer Institute

Professional Education

Ph.D., Stanford University, Chemical and Systems Biology (2008)
M.S., Stanford University, Computer Science (2000)
B.S., University of California, San Diego, Computer Science (1998)

2023-24 Courses

Biochemistry Mini-Course
BIOC 202 (Aut)

Independent Studies
- Directed Reading in Biochemistry
  BIOC 299 (Aut, Win, Spr, Sum)
- Directed Reading in Biophysics
  BIOPHYS 399 (Aut, Win, Spr, Sum)
- Graduate Research
  BIOPHYS 300 (Aut, Win, Spr, Sum)
- Graduate Research and Special Advanced Work
  BIOC 399 (Aut, Win, Spr, Sum)
- Medical Scholars Research
  BIOC 370 (Aut, Win, Spr, Sum)
- Out-of-Department Graduate Research
  BIO 300X (Aut, Win, Spr, Sum)
- The Teaching of Biochemistry
  BIOC 221 (Aut, Win, Spr, Sum)
- Undergraduate Research
  BIOC 199 (Aut, Win, Spr, Sum)

Prior Year Courses

2022-23 Courses

Biochemistry Mini-Course
BIOC 202 (Aut)

2021-22 Courses

Biochemistry Mini-Course
BIOC 202 (Aut)
Proteostatis: guarding the proteome in health and disease
BIOS 287 (Win)

2020-21 Courses

Advanced Cell Biology
BIO 214, BIOC 224, MCP 221 (Win)
Biochemistry Mini-Course
BIOC 202 (Aut)

Stanford Advisees

Postdoctoral Faculty Sponsor
Danish Khan
Doctoral Dissertation Advisor (AC)
Kathy Le, Angel Madero Rincon, Jacob Schwartz, Eduardo Tassoni Tsuchida, Ananya Vinayak
Postdoctoral Research Mentor
Danish Khan
Doctoral (Program)
Angel Madero Rincon, Eduardo Tassoni Tsuchida

Graduate and Fellowship Programs

All Publications

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Raymond Chen

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Wah Chiu

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Research Interests
My research includes methodology improvements in single particle cryo-EM for atomic resolution structure determination of molecules and molecular machines, as well as in cryo-ET of cells and organelles towards subnanometer resolutions. We collaborate with many researchers around the country and outside the USA on understanding biological processes such as protein folding, virus assembly and disassembly, pathogen-host interactions, signal transduction, and transport across cytosol and membranes.

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Martha S. Cyert

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Research Interests
The Cyert lab is identifying signaling networks for calcineurin, the conserved Ca2+/calmodulin-dependent phosphatase, and target of immunosuppressants FK506 and cyclosporin A, in yeast and mammals. Cell biological investigations of target dephosphorylation reveal calcineurin’s many physiological functions. Roles for short linear peptide motifs, or SLiMs, in substrate recognition, network evolution, and regulation of calcineurin activity are being studied.

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Scott Dixon

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My lab is interested in the relationship between cell death and metabolism. Using techniques drawn from many disciplines my laboratory is investigating how perturbation of intracellular metabolic networks can result in novel forms of cell death, such as ferroptosis. We are interested in applying this knowledge to find new ways to treat diseases characterized by insufficient (e.g. cancer) or excessive (e.g. neurodegeneration) cell death.

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James Ferrell

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Research Interests
My lab has two main goals: to understand the regulation of mitosis and to understand the systems-level logic of simple signaling circuits. We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study. We also carry out single-cell fluorescence imaging studies on mammalian cell lines. Our experimental work is complemented by computational and theoretical studies aimed at understanding the design principles and recurring themes of regulatory circuits.

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Hunter Fraser

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Research Interests
We study the evolution of complex traits by developing new experimental and computational methods.

Our work brings together quantitative genetics, genomics, epigenetics, and evolutionary biology to achieve a deeper understanding of how genetic variation shapes the phenotypic diversity of life. Our main focus is on the evolution of gene expression, which is the primary fuel for natural selection. Our long-term goal is to be able to introduce complex traits into new species via genome editing.

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Judith Frydman

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Research Interests
The long term goal of our research is to understand how proteins fold in living cells. My lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer and neurodegenerative diseases and examine whether reengineering chaperone networks can provide therapeutic strategies.

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Michelle Hays

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Stephen M. Hinshaw

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