School of Medicine
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Greer Murphy M.D., Ph.D.
Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology-Adult), Emeritus
Current Research and Scholarly Interests Pharmacogenetics of mood disorders and nicotine addiction. Microglial neurotoxicity and neuroprotection in Alzheimer's disease. Genome wide expression analysis of mouse models for Alzheimer's disease.
Kelly P. Murphy, MD
Clinical Associate Professor, Emergency Medicine
Current Research and Scholarly Interests Global Health: rural healthcare delivery systems and grassroots health education.
Medical Development: collaborating with an international team of NGOs to rebuild the national healthcare system in Papua New Guinea.
Professor of Medicine (Medical Informatics) and of Biomedical Data Science
Current Research and Scholarly Interests My laboratory investigates the use of distributed, component-based software architectures to build intelligent computer systems. Emphasis is on knowledge modeling and knowledge reuse. Our goals are to enhance methodologies that faculitate building and maintaining electronic knowledge bases that can drive useful biomedical computer systems. Current work concentrates on automation of clinical practice guidelines and clinical-trial protocols, and surveillance for potential episodes of bioterrorism.
Assistant Professor of Otolaryngology - Head and Neck Surgery
Current Research and Scholarly Interests Hearing is one of the most sensitive functions controlled by thyroid hormone (TH). TH is required for the timely coordination of a complex set of differentiation events in the maturing cochlea. Hypothyroidism retards the differentiation of the cochlea, including synaptogenesis, neurogenesis and myelinogenesis. The mechanisms that prompt the progression of these developmental events are poorly understood. Our preliminary data shows that many genes are differentially regulated by thyroid hormone in the cochlea.
Identifying which of these genes play important roles in cochlear hair cell innervation and synapse formation will further basic understanding about how the auditory system develops. In addition, knowledge of these genes could help devise strategies for stimulating the innervation of newly generated hair cells. To establish or restore hearing, it is vital that newly formed hair cells be connected functionally to the brain. We expect that our research will contribute to this important clinical/translational research effort by identifying genes involved in stimulating innervation and synapse formation.
Professor of Medicine (Nephrology), Emeritus
Current Research and Scholarly Interests A novel approach is used to evaluate glomerular disease in humans, and its progression. A combination of physiologic techniques, a morphometric analysis of glomeruli obtained by biopsy, and mathematical modeling of glomerular ultrafiltration is used to quantify the extent of glomerular injury in humans for the first time.
Assistant Professor of Molecular and Cellular Physiology
Current Research and Scholarly Interests We study the primary cilium, a surface-exposed organelle required for vision, olfaction and developmental signaling and whose dysfunction leads to obesity, skeletal malformations and kidney cysts. To decode the fundamental principles of ciliary trafficking and to understand how trafficking shapes signaling at the primary cilium, we leverage a broad expertise in biochemistry, proteomics, cell biology and in vitro reconstitution.