School of Medicine

Showing 4,211-4,220 of 6,489 Results

  • Dwight Nishimura

    Dwight Nishimura

    Addie and Al Macovski Professor in the School of Engineering

    Current Research and Scholarly Interests medical imaging, magnetic resonance imaging

  • Toshinobu Nishimura

    Toshinobu Nishimura

    Postdoctoral Research Fellow, Stem Cell Biology and Regenerative Medicine

    Current Research and Scholarly Interests In my undergraduate and graduate school, my research interests are in the development of bloods cells especially immune cells from hematopoietic stem cells (HSCs). As an undergraduate, I conducted research with Dr. Hitoshi Sakano on elucidating the mechanism of the diversification of the immune receptors in jaw-less animals (more primitive species than fish) such as sea lamprey and hagfish. Sea lamprey and hagfish has different type of immune receptor gene from T-cell receptor (TCR) or Immunoglobulin (Ig), and gene assembly other than V(D)J recombination occurs on the gene for diversifying it. By using immunogenetics, molecular biology, and computational method I uncovered the way for diversifying the immune receptor gene in these species.

    I switched my research field to rodents in my former half of Ph.D. course. With Dr. Hiromitsu Nakauchi I focused on generating transplantable HSC from mouse embryonic stem cells (ESCs). I could purify and phenotyped the population which have the capacity for engrafting and repopulating in mouse bone marrow after transplantation. In latter half of Ph.D. course, I combined my knowledge about immunology with HSC induction technique for generating immune cells from human induced pluripotent stem cells (iPSCs). I succeeded to obtain abundant and highly functional antigen-specific T cells from human iPSCs, along with rejuvenating the exhausted state by passing through iPSC-reprogramming and redifferentiation.

    For research in postdoctoral fellow, I choose to generate 3D organs from human iPSCs. It is very challenging theme but I?m thinking my experiences, knowledge, and techniques in pluripotent stem cells should bear fruit. I continue the T-cell generation research and I?m planning to translate the T-cell products to clinic.

  • Seiji Nishino

    Seiji Nishino

    Professor (Research) of Psychiatry & Behavioral Sciences, Emeritus

    Current Research and Scholarly Interests The research focus of the Sleep and Circadian Neurobiology (SCN) Laboratory is the study of the sleep and circadian physiology using various animal models. A portion of the research is carried out using rodent models of narcolepsy and circadian rhythm sleep disorders. The laboratory also carries out pharmacological studies aiming to develop new treatments for these sleep disorders.

  • Ryan Nitta

    Ryan Nitta

    Sr Res Scientist-Basic Life, Neurosurgery

    Current Role at Stanford The main project of the Li lab is to elucidate the signaling pathways responsible for maintaining and initiating brain tumor growth. Previously the Li lab has identified an interesting protein, known as casein kinase 2, which plays an integral role in adult brain tumor growth. My goal is to expand on this initial finding and determine if casein kinase 2 could be a therapeutically relevant drug target in adult brain tumors and whether this protein plays a role in pediatric brain tumors. The role of the candidate would be the lead researcher on these projects, as well as managing and leading the undergraduate and medical students in the lab. In addition, I am responsible for maintaining the laboratory and assisting in grant writing.

  • Jonathan Nizar

    Jonathan Nizar

    Clinical Instructor, Medicine - Nephrology

    Current Research and Scholarly Interests Diabetes and hypertension are among the most common diseases treated in the US. The combination of these disease greatly increased the risk of heart attack, stroke, and early death. While over 90% of patients with diabetes have high blood pressure, its cause is unknown. Working in the laboratory of Vivek Bhalla, I am interested in understanding the mechanisms that diabetes contributes to high blood pressure. We current are focused on the regulatory role of insulin on sodium reabsorption in the kidney, which is a master regulator of blood pressure. Using a mouse model of diabetes and transgenic technologies, we utliize classical metabolic experiments, expression, electrophysiological, and primary cell culture techniques to understand the role of insulin in regulating sodium transport in the kidney, blood volume in the body, and increased blood pressure in diabetes.

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