Current Research and Scholarly Interests
The primary aim of my lab is to enable early detection and precision treatment of devastating brain diseases by developing translational molecular imaging agents for visualizing neuroimmune interactions underlying conditions such as Alzheimer?s disease, multiple sclerosis, and stroke.
We are researching how the brain and its resident immune cells interact with the peripheral immune system at very early, through to late stages of disease. Our approach involves the discovery, characterization, and validation of clinically relevant immune cell biomarkers, followed by the design of novel positron emission tomography (PET) radiotracers specifically targeting these biomarkers. After preclinical validation, we translate promising imaging probes to the clinic for precision targeting of immunomodulatory therapeutics and real-time monitoring of treatment response.