John V. Gahagan, MD

All Publications

• Hand-assisted laparoscopic colon resection: review of literature and technique ANNALS OF LAPAROSCOPIC AND ENDOSCOPIC SURGERY Gahagan, J. V., Garrett, K. A. 2019; 4

  View details for DOI 10.21037/ales.2019.03.01

  View details for Web of Science ID 000461528000002

• Management of Acute Intestinal Ischaemia Keighley & Williams? Surgery of the Anus, Rectum and Colon Stamos, M. J., Gahagan, J. V. CRC Press. 2019; 4: 1385?1398
• Improved survival with adjuvant chemotherapy in locally advanced rectal cancer patients treated with preoperative chemoradiation regardless of pathologic response. Surgical oncology Gahagan, J. V., Whealon, M. D., Phelan, M. J., Mills, S., Jafari, M. D., Carmichael, J. C., Stamos, M. J., Zell, J. A., Pigazzi, A. 2019; 32: 35?40

  Abstract

  The aim of this study is to examine the effect of postoperative chemotherapy on survival in patients with stage II or III rectal adenocarcinoma who undergo neoadjuvant chemoradiation (CRT) and surgical resection.A retrospective review of the National Cancer Database (NCDB) from 2006 to 2013 was performed. Cases were analyzed based on pathologic complete response (pCR) status and use of adjuvant therapy. The Kaplan-Meier method was used to estimate overall survival probabilities.23,045 cases were identified, of which 5832 (25.31%) achieved pCR. In the pCR group, 1513 (25.9%) received adjuvant chemotherapy, and in the non-pCR group, 5966 (34.7%) received adjuvant therapy. In the pCR group, five-year survival probability was 87% (95% CI 84%-89%) with adjuvant therapy and 81% (95% CI 79%-82%) without adjuvant therapy. In the non-pCR group, five-year survival probability was 78% (95% CI 76%-79%) with adjuvant therapy and 70% (95% CI 69%-71%) without adjuvant therapy. In the non-pCR and node-negative subgroup (ypN-), five-year survival probability was 86% (95% CI 84%-88%) with adjuvant therapy and 76% (95% CI 74%-77%) without adjuvant therapy. In the non-pCR and node-positive subgroup (ypN+), five-year survival probability was 67% (95% CI 65%-70%) with adjuvant therapy and 60% (95% CI 58%-63%) without adjuvant therapy.Adjuvant chemotherapy in stage II or III rectal adenocarcinoma is associated with increased five-year survival probability regardless of pCR status. We observed similar survival outcomes among non-pCR ypN- treated with adjuvant chemotherapy compared with patients achieving pCR treated with adjuvant chemotherapy.

  View details for DOI 10.1016/j.suronc.2019.10.021

  View details for PubMedID 31726418

• Robotic Low Anterior Resection SAGES Atlas of Robotic Surgery Gahagan, J. V., Pigazzi, A. Springer. 2018: 273?280
• An Analysis of Risk Factors, Timing of Complications and Readmission after Pancreaticoduodenectomy Journal of Gastroenterology, Pancreatology & Liver Disorders Gahagan, J. V., Hanna, M. H., Moghadamyeghaneh, Z., Alizadeh, R. F., Nguyen, A., Yamamoto, M., Stamos, M. J., Demirjian, A. N., Imagawa, D. K. 2018

  View details for DOI 10.15226/2374

• Lymph Node Positivity in Appendiceal Adenocarcinoma: Should Size Matter? Journal of the American College of Surgeons Gahagan, J. V., Whealon, M. D., Phelan, M. J., Mills, S., Pigazzi, A., Stamos, M. J., Nguyen, N. T., Carmichael, J. C. 2017; 225 (1): 69?75

  Abstract

  The management algorithm for appendiceal adenocarcinoma is not well defined. This study sought to determine whether tumor size or depth of invasion better correlates with the presence of lymph node metastases in appendiceal adenocarcinoma, and to compare these rates with colon adenocarcinoma.A retrospective review of the National Cancer Database was performed to identify patients with appendiceal or colonic adenocarcinoma from 2004 to 2013 who underwent surgical resection. Cases were categorized by tumor size and by T stage. Rates of lymph node metastases were examined as a function of size and T stage.A total of 3,402 appendiceal and 314,864 colonic cases were identified. For appendiceal adenocarcinoma, larger tumor size was associated with higher T stage: Pearson correlation of 0.41 (95% CI 0.408 to 0.414; p < 0.001). Lymph node metastases were present in 19.1%, 27.8%, 39.6%, 39.4%, 42.4% and 39.1% for tumor sizes <1 cm, >1 to 2 cm, >2 to 3 cm, >3 to 4 cm, >4 to 5 cm, and >5 cm, respectively. Lymph node metastases were present in 0%, 11.2%, 12.3%, 35.5%, and 40.0% for in situ, T1, T2, T3, and T4 tumors, respectively. There was no difference in the rates of lymph node metastases between appendiceal and colonic adenocarcinoma for tumor sizes <3 cm, or for in situ and T1 tumors. Rates of lymph node metastases are higher in colonic adenocarcinoma for tumor sizes >3 cm and for T2, T3, and T4 tumors (p < 0.01).In appendiceal adenocarcinoma, the rate of lymph node metastases is substantial, even for small tumors. Tumor size should play no role in the decision of whether to perform a hemicolectomy. Appendectomy alone does not produce an adequate lymph node sample. Right hemicolectomy should be performed for all appendiceal adenocarcinomas.

  View details for DOI 10.1016/j.jamcollsurg.2017.01.056

  View details for PubMedID 28188838

• Robotic Abdominoperineal Resection Robotic Colon and Rectal Surgery: Principles and Practice Hwang, G. S., Gahagan, J. V., Pigazzi, A. Springer. 2017: 49?57
• Defining the Role of Minimally Invasive Proctectomy for Locally Advanced Rectal Adenocarcinoma. Annals of surgery Sujatha-Bhaskar, S., Jafari, M. D., Gahagan, J. V., Inaba, C. S., Koh, C. Y., Mills, S. D., Carmichael, J. C., Stamos, M. J., Pigazzi, A. 2017; 266 (4): 574?81

  Abstract

  National examination of open proctectomy (OP), laparoscopic proctectomy (LP), and robotic proctectomy (RP) in pathological outcomes and overall survival (OS).Surgical management for rectal adenocarcinoma is evolving towards utilization of LP and RP. However, the oncological impacts of a minimally invasive approach to rectal cancer have yet to be defined.Retrospective review of the National Cancer Database identified patients with nonmetastatic locally advanced rectal adenocarcinoma from 2010 to 2014, who underwent neoadjuvant chemoradiation, surgical resection, and adjuvant therapy. Cases were stratified by surgical approach. Multivariate analysis was used to compare pathological outcomes. Cox proportional-hazard modeling and Kaplan-Meier analyses were used to estimate long-term OS.Of 6313 cases identified, 53.8% underwent OP, 31.8% underwent LP, and 14.3% underwent RP. Higher-volume academic/research and comprehensive community centers combined to perform 80% of laparoscopic cases and 83% of robotic cases. In an intent-to-treat model, multivariate analysis demonstrated superior circumferential margin negativity rates with LP compared with OP (odds ratio 1.34, 95% confidence interval 1.02-1.77, P = 0.036). Cox proportional-hazard modeling demonstrated a lower death hazard ratio for LP compared with OP (hazard ratio 0.81, 95% confidence interval 0.67-0.99, P = 0.037). Kaplan-Meier analysis demonstrated a 5-year OS of 81% in LP compared with 78% in RP and 76% in OP (P = 0.0198).In the hands of experienced colorectal specialists treating selected patients, LP may be a valuable operative technique that is associated with oncological benefits. Further exploration of pathological outcomes and long-term survival by means of prospective randomized trials may offer more definitive conclusions regarding comparisons of open and minimally invasive technique.

  View details for DOI 10.1097/SLA.0000000000002357

  View details for PubMedID 28650357

• Is Fecal Diversion Needed in Pelvic Anastomoses During Hyperthermic Intraperitoneal Chemotherapy (HIPEC)? Annals of surgical oncology Whealon, M. D., Gahagan, J. V., Sujatha-Bhaskar, S., O'Leary, M. P., Selleck, M., Dumitra, S., Lee, B., Senthil, M., Pigazzi, A. 2017; 24 (8): 2122?28

  Abstract

  The role of fecal diversion with pelvic anastomosis during cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is not well defined.A retrospective review of patients who underwent CRS and HIPEC between 2009 and 2016 was performed to identify those with a pelvic anastomosis (colorectal, ileorectal, or coloanal anastomosis).The study identified 73 patients who underwent CRS and HIPEC at three different institutions between July 2009 and June of 2016. Of these patients, 32 (44%) underwent a primary anastomosis with a diverting ileostomy, whereas 41 (56%) underwent a primary anastomosis without fecal diversion. The anastomotic leak rate for the no-diversion group was 22% compared with 0% for the group with a diverting ileostomy (p < 0.01). The 90-day mortality rate for the no-diversion group was 7.1%. The hospital stay was 14.1 ± 8.0 days in the diversion group compared with 17.9 ± 12.5 days in the no-diversion group (p = 0.12). Of those patients with a diverting ileostomy, 68% (n = 22) had their bowel continuity restored, 18% of which required a laparotomy for reversal. Postoperative complications occurred for 50% of those who required a laparotomy and for 44% of those who did not require a laparotomy (p = 0.84).Diverting ileostomies in patients with a pelvic anastomosis undergoing CRS and HIPEC are associated with a significantly reduced anastomotic leak rate. Reversal of the diverting ileostomy in this patient population required a laparotomy in 18% of the cases and had an associated morbidity rate of 50%.

  View details for DOI 10.1245/s10434-017-5853-z

  View details for PubMedID 28411306

• Volume and outcomes relationship in laparoscopic diaphragmatic hernia repair. Surgical endoscopy Whealon, M. D., Blondet, J. J., Gahagan, J. V., Phelan, M. J., Nguyen, N. T. 2017; 31 (10): 4224?30

  Abstract

  There is no published data regarding the relationship between hospital volume and outcomes in patients undergoing laparoscopic diaphragmatic hernia repair. We hypothesize that hospitals performing high case volume have improved outcomes compared to low-volume hospitals.We reviewed the National Inpatient Sample (NIS) database between 2008 and 2012 for adults with the diagnosis of diaphragmatic hernia who underwent elective laparoscopic repair of diaphragmatic Hernia and/or Nissen fundoplication. Pediatric, emergent, and open cases were excluded. Main outcome measures included logistic regression analysis of factors predictive of in-hospital mortality and outcomes according to annual hospital case volume.A total of 31,228 laparoscopic diaphragmatic hernia operations were analyzed. The overall in-hospital mortality was 0.14%. Risk factors for higher in-hospital mortality included renal failure (AOR: 6.26; 95% CI: 2.48-15.78; p?60 years (AOR: 5.06; 95% CI: 2.38-10.76; p?

  View details for DOI 10.1007/s00464-017-5482-4

  View details for PubMedID 28342131

• Robotic low anterior resection SEMINARS IN COLON AND RECTAL SURGERY Gahagan, J. V., Pigazzi, A. 2016; 27 (3): 150?54

  View details for DOI 10.1053/j.scrs.2016.04.007

  View details for Web of Science ID 000382669800007

• Colorectal Surgery in Patients with HIV and AIDS: Trends and Outcomes over a 10-Year Period in the USA. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract Gahagan, J. V., Halabi, W. J., Nguyen, V. Q., Carmichael, J. C., Pigazzi, A., Stamos, M. J., Mills, S. D. 2016; 20 (6): 1239?46

  Abstract

  HIV has become a chronic disease, which may render this population more prone to developing the colorectal pathologies that typically affect older Americans.A retrospective review of the Nationwide Inpatient Sample was performed to identify patients who underwent colon and rectal surgery from 2001 to 2010. Multivariate analysis was used to evaluate outcomes among the general population, patients with HIV, and patients with AIDS.Hospital admissions for colon and rectal procedures of patients with HIV/AIDS grew at a faster rate than all-cause admissions of patients with HIV/AIDS, with mean yearly increases of 17.8 and 2.1 %, respectively (p?

  View details for DOI 10.1007/s11605-016-3119-x

  View details for PubMedID 26940943

• Hand-Assisted Laparoscopic Donor Nephrectomy in Complete Situs Inversus. Journal of endourology case reports Gahagan, J. V., Whealon, M. D., Reddy, U., Foster, C. E., Ichii, H. 2016; 2 (1): 108?10

  Abstract

  Complete situs inversus is a rare congenital anomaly characterized by transposition of organs. We report a case of renal transplantation using a kidney from a living complete situs inversus donor. The recipient was a 59-year-old female with end-stage renal disease because of type 2 diabetes mellitus. The donor was the 56-year-old sister of the recipient with complete situs inversus. CT angiogram of the abdomen and pelvis showed complete situs inversus and an otherwise normal appearance of the bilateral kidneys with patent bilateral single renal arteries and longer renal vein in the right kidney. The patient was taken to the operating room for a hand-assisted laparoscopic right donor nephrectomy. The patient tolerated the procedure well and was discharged home in good condition on postoperative day 1. The recipient experienced no episodes of acute rejection or infection, with serum creatinine levels of 0.8-1.2?mg/dL. Laparoscopic donor nephrectomy in a patient with complete situs inversus remains a technically feasible operation and the presence of situs inversus should not preclude consideration for living kidney donation.

  View details for DOI 10.1089/cren.2016.0045

  View details for PubMedID 27579434

  View details for PubMedCentralID PMC4996604

• Racial Disparities in Access and Outcomes of Cholecystectomy in the United States. The American surgeon Gahagan, J. V., Hanna, M. H., Whealon, M. D., Maximus, S., Phelan, M. J., Lekawa, M., Barrios, C., Bernal, N. P. 2016; 82 (10): 921?25

  Abstract

  Disparities in access to health care between white and minority patients are well described. We aimed to analyze the trends and outcomes of cholecystectomy based on racial classification. The Nationwide Inpatient Sample database was reviewed for all patients undergoing cholecystectomy from 2009 to 2012. Patients were stratified as white or non-white. A total of 243,536 patients were analyzed: 159,901 white and 83,635 non-white. Non-white patients had significantly higher proportions of Medicaid (25% vs 9.3%), self-pay (14% vs 7.1%), and no-charge (1.8% vs 0.64%). Non-white patients had significantly higher rates of emergent admission (84% vs 78%) compared with the white patients. Multivariate analysis revealed that non-whites had a significantly longer length of stay [mean difference of 0.14 days, 95% confidence interval (CI) 0.08-0.20] and higher total hospital charges (mean difference of $6748.00, 95% CI 5994.19-7501.81) than whites, despite a lower morbidity (odds ratio 0.94, 95% CI 0.90-0.98). Use of laparoscopy and mortality were not different. These differences persisted on subgroup analysis by insurance type. These findings suggest a gap in access to and outcomes of cholecystectomy in the minority population nationwide.

  View details for PubMedID 27779974

• Analysis of Endoscopic Retrograde Cholangiopancreatography after Positive Intraoperative Cholangiogram: Is It Necessary? The American surgeon Gahagan, J. V., Maximus, S., Whealon, M. D., Phelan, M. J., Demirjian, A., Joe, V. C. 2016; 82 (10): 985?88

  Abstract

  The necessity of routine endoscopic retrograde cholangiopancreatography (ERCP) after positive intraoperative cholangiogram (IOC) during laparoscopic cholecystectomy is not well defined. We aimed to examine the incidence of positive IOC among patients who undergo IOC during cholecystectomy and the rate of subsequent ERCP stone extraction. The Nationwide Inpatient Sample database was reviewed for all patients undergoing cholecystectomy with IOC from 2002 to 2012. Patients were then analyzed for ERCP and stone extraction. A total of 73,508 patients who underwent cholecystectomy with IOC for a diagnosis of acute cholecystitis and found to have a bile duct stone were identified. Of these patients, 5915 underwent subsequent ERCP. In the patients that underwent subsequent ERCP, 1478 had a documented stone extraction during ERCP. The rate of stone extraction in the ERCP subset is 25 per cent, which is 2 per cent of all patients who had a positive IOC. The rate of stone extraction after positive IOC is low. Positive IOC may not warrant a routine postoperative ERCP. Our results suggest that clinical monitoring of patients with positive IOC is reasonable, as the majority of patients with a positive IOC ultimately have no stone extraction.

  View details for PubMedID 27779989