Bio
Our lab works at the interface of biotechnology, computational biology, cellular biology, and clinical medicine to develop and apply new tools for characterizing genetic variation across single cells within a tissue with unparalleled sensitivity and accuracy. We are focused on applying these technologies to study cancer clonal evolution while patients are undergoing treatment with the aim of identifying cancer clonotypes that are associated with resistance to specific drugs so as to better understand and predict treatment response. We are also applying these methods to understand how more virulent pathogens emerge from a population of bacteria or viruses with an emphasis on developing a deeper understanding of how antibiotic resistance develops.
Clinical Focus
- Pediatric Hematology-Oncology
- Acute Lymphoblastic Leukemia
Honors & Awards
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Investigator, Chan Zuckerberg Biohub (2019-2024)
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Taube Distinguished Scholar for Pediatric Oncology, Stanford (2019-2024)
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New Innovator Award, Office of Director, National Institutes of Health (2018-2023)
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Career Award for Medical Scientists, Burroughs Wellcome Fund (2015-2020)
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Special Fellow, Leukemia and Lymphoma Society (2013-2016)
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Fellow Basic Research Scholar, American Society of Hematology (2013-2015)
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Advanced Residency Training Program, Stanford (2011-present)
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Fellowship for Medical Students Continued Support Award, HHMI (2003-2005)
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Cloister Scholar, HHMI-NIH (2002-2003)
Boards, Advisory Committees, Professional Organizations
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Founder, Board DIrector, BioSkryb, Inc. (2019 - Present)
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Editorial Board Member, Nucleic Acids Research Cancer (2019 - Present)
Professional Education
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Residency: UCLA Pediatric Residency (2009) CA
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PhD Training: Stanford University School of Medicine - Office of Graduate Affairs - Postdoctoral Affairs (2015) CA
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Board Certification: American Board of Pediatrics, Pediatric Hematology-Oncology (2013)
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Fellowship: Stanford University Pediatric Hematology Oncology Fellowship (2012) CA
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Board Certification: American Board of Pediatrics, Pediatrics (2010)
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Medical Education: University of Arizona College of Medicine Office of the Registrar (2006) AZ
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PhD, Stanford University, Cancer Biology (2015)
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MD, University of Arizona, Medicine (2006)
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BS, Arizona State University, Chemistry and Microbiology (2001)
Patents
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Charles Gawad, Veronica Gonzalez-Pena, Robert Carter, Sivaraman Natarajan, Jason West. "United States Patent 62/881,180 Genetic Mutation Analysis"
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Charles Gawad, Jason West. "United States Patent 62/881,183 Single Cell Analysis"
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Charles Gawad, Jason West, Paul McEwan. "United States Patent 62/972,557 Phi29 Mutants and Use Thereof"
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Charles Gawad, Veronica Gonzalez-Pena, John Easton. "United States Patent WO2019148119A1 Method for Nucleic Acid Amplification"
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Charles Gawad, Siddhartha Kadia, Jason West. "United StatesDetection of Low Abundance Nucleic Acids", Apr 28, 2020
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Charles Gawad, Jason West, Jon Zawistowski. "United States Patent 55461-706.101 Detection of Low Abundance Viruses", Mar 31, 2020