School of Medicine
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Director, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Virginia & D.K. Ludwig Professor for Clinical Investigation in Cancer Research, Professor of Developmental Biology and, by courtesy, of Biology
Current Research and Scholarly Interests Stem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis.
Professor of Pathology and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests Epigenetic Reprogramming, Direct conversion of fibroblasts into neurons, Pluripotent Stem Cells, Neural Differentiation: implications in development and regenerative medicine
Professor of Pathology at the Stanford University Medical Center
Current Research and Scholarly Interests Rob West, MD, PhD, is a Professor of Pathology at Stanford University Medical Center. He is a clinician scientist with experience in translational genomics research to identify new prognostic and therapeutic markers in cancer. His research focus is on the progression of neoplasia to carcinoma. His lab has developed spatially oriented in situ methods to study archival specimens. He also serves as a surgical pathologist specializing in breast pathology.
Current Research and Scholarly Interests I'm interested in both basic and translational cardiovascular biology, regenerative medicine and genomics. Much of my work merges next generation sequencing (NGS) with iPS cell models to find and characterize primate-specific elements within the noncoding genome (lncRNAs, transposable elements, enhancers). Some of these primate elements appear to regulate heart development, disease and even evolution, and with the enormous growth in pluripotent cell technologies their functions can now be experimentally studied. In translational work, I'm developing custom targeted NGS assays for identifying the DNA mutations that underlie cardiomyopathies and other heart diseases.
Associate Professor of Genetics and of Pathology
Current Research and Scholarly Interests Our laboratory uses genome-wide methods to uncover alterations that drive cancer progression and metastasis in genetically-engineered mouse models of human cancers. We combine cell-culture based mechanistic studies with our ability to alter pathways of interest during tumor progression in vivo to better understand each step of metastatic spread and to uncover the therapeutic vulnerabilities of advanced cancer cells.