School of Medicine
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Brian A. Wandell
Isaac and Madeline Stein Family Professor and Professor, by courtesy, of Electrical Engineering, of Ophthalmology and at the Graduate School of Education
Current Research and Scholarly Interests Models and measures of the human visual system. The brain pathways essential for reading development. Diffusion tensor imaging, functional magnetic resonance imaging and computational modeling of visual perception and brain processes.
Postdoctoral Research Fellow, Ophthalmology
Current Research and Scholarly Interests My research interests are to identify and to elucidate the key signaling pathways in Lowe Syndrome disease, and also to develop a targeted therapy for Lowe syndrome patients. So far, there is no treatment for Lowe syndrome. I have a broad background in cell biology, with specific training and expertise in protein trafficking and signaling pathways.
Sophia Ying Wang, MD
Clinical Instructor, Ophthalmology
Current Research and Scholarly Interests I use and integrate a wide variety of data sources in my research, spanning both structured and unstructured forms, including national survey datasets, health insurance claims data, patient generated online text, and electronic health records. I investigate outcomes of treatments for glaucoma and cataract, as well as other areas of ophthalmology, while developing and applying novel methods for automated extraction of ophthalmic data from free text.
Sui Wang, PhD
Assistant Professor of Ophthalmology
Current Research and Scholarly Interests Our research focuses on understanding the molecular mechanisms that underlie retinal development and diseases. We utilize genetic and genomic tools to uncover how different types of retinal cells, including retinal neurons, glia and the vasculature, respond to developmental cues and disease insults at the epigenomic and transcriptional levels, and how they interact and collectively contribute to the integrity of the retina.
1. Retinal cell fate specification.
We are using genetic tools and methods, such as in vivo plasmid electroporation and CRISPR, to dissect the roles of cis-regulatory elements and transcription factors in controlling retinal cell fate specification.
2. The multicellular responses elicited by diabetes in the retina.
Diabetes can induce multicellular responses in the retina, including vascular lesions, glial dysfunction and neurodegeneration, all of which contribute to retinopathy. We are using diabetic rats as models to investigate the detailed molecular mechanisms underlying the diabetes-induced multicellular responses, and the disease mechanisms of diabetic retinopathy.
3. Molecular tools that allow for cell type-specific labeling and manipulation in vivo.
Cis-regulatory elements, such as enhancers, play essential roles in directing tissue/cell type-specific and stage-specific expression. We are interested in identifying enhancers that can drive cell type-specific expression in the retina and brain, and incorporating them into plasmid or AAV based delivery systems.