School of Medicine
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Dr Husein Hadeiba
Affiliate, Pathology VA Faculty PTAs
Bio My research interests center on understanding how dendritic cells (DCs) regulate the immune response. Specifically we are interested in the role of DC trafficking in inflammation and in the maintenance of immune homeostasis and tolerance. To understand these processes, we are examining the mechanisms of DC homing to sites of immune tolerance such as (i) the thymus-the site of central tolerance, and (ii) the gut mucosa-where immune responses to commensal and ingested antigens (Ags) are shut down. We are also interested in understanding how microenvironmental tissue factors influence DC development and their ability to imprint unique homing properties on T cells. DCs are unique messenger white blood cells of the mammalian immune system. They function as specialized antigen-presenting cells (APCs), whose main function is to process and transport Ags and microenvironmental signals from the tissues to the draining lymph nodes for presentation to T cells. In the last decade, a large number of DC subsets have been characterized in part defined by their expression of unique trafficking and adhesion receptors, and migratory properties. We therefore would like to understand how these trafficking and adhesion receptors define their function and phenotype and how they are regulated by the tissue microenvironment, with the hope of targeting unique DC subsets to suppress chronic inflammation or to improve anti-tumor responses in immunotherapy.
Postdoctoral Research Fellow, Pathology
Bio Dr. Hartmann received a B.Sc. and M.Sc. in Molecular Biotechnology from the University of Heidelberg, Germany. During his M.Sc. studies, he additionally performed a research internship studying the role of chimeric antigen receptor (CAR) T cells at the Weizmann Institute in Israel under the supervision of Prof. Zelig Eshhar.
He then obtained a PhD from the University of Zurich, Switzerland for his research on T cell functionality in human autoimmune diseases. Following his stay in Zurich, Dr. Hartmann has since performed his postdoctoral training in the laboratory of Dr. Sean Bendall, with funding from the Swiss National Science Foundation (SNF), the Novartis Foundation for biomedical research, and EMBO.
His current research focuses on using high-dimensional protein assays such as mass cytometry (CyTOF) and multiplexed ion beam imaging (MIBI) to study functional properties of immune cells in autoimmunity and cancer immunotherapy.
Florette K. Gray Hazard
Associate Professor of Pathology and of Pediatrics at the Stanford University Medical Center
Current Research and Scholarly Interests My scholarly pursuits are primarily focused on the study of death and disease in the pediatric population. It is through this work that I am able to explore fundamental concepts of neoplasia, such as histogenesis and mutagenesis, while utilizing a variety of investigational techniques.
Professor of Pathology at the Stanford University Medical Center, Emeritus
Current Research and Scholarly Interests Diagnosis of progressive stages of uterine cancer; classification of ovarian tumors; breast cancer diagnosis and prognostic factors, soft tissue neoplasm, uterine mesenchymal neoplasm.
Professor of Pathology at the Stanford University Medical Center
Current Research and Scholarly Interests I work as a diagnostic surgical pathologist doing translational research in renal neoplasia and medical renal disease and neoplastic and medical liver disease. Subspecialty areas of clinical interest include diagnostic immunohistochemistry, renal, hepatic and transplant pathology.
Marie Hollenhorst, MD, PhD
Clinical Instructor, Pathology
Bio Dr. Hollenhorst is a physician and scientist with expertise in non-malignant hematology, transfusion medicine, and chemical biology. Dr. Hollenhorst values the one-on-one relationships that she forms with her patients, and strives to deliver the highest quality of care for individuals with blood diseases. Her experience caring for patients drives her to ask scientific questions in the laboratory, where she aims to bring a chemical approach to the study of non-malignant blood disease.
Dr. Hollenhorst pursued combined MD and PhD training at Harvard University, where she received a PhD in Chemical Biology under the mentorship of Professor Christopher T Walsh. She subsequently completed a residency in Internal Medicine at Brigham and Women's Hospital, a fellowship in Transfusion Medicine at Harvard Medical School, and a fellowship in Hematology at Stanford.
Dr. Hollenhorst has a particular interest in the biology of platelets, which are cellular fragments that help the blood to maintain a healthy balance between excessive bleeding and excessive clotting. Working in the laboratory of Professor Carolyn Bertozzi of Stanford Chemistry, Dr. Hollenhorst is studying sugar-containing molecules that are found within platelets and are important in controlling their function and lifespan.
Dr. Hollenhorst's research is supported by a Stanford Chemistry, Engineering & Medicine for Human Health Physician-Scientist Fellowship, a National Institutes of Health Individual Postdoctoral Fellowship, and a National Blood Foundation Early-Career Scientific Research Grant.
Professor (Clinical) of Pathology, Emeritus
Current Research and Scholarly Interests Neuropathology of:
1. Neurodegenerative diseases
2. Neurodevelopmental disorders
3. CNS neoplasms
4. Nerve & muscle diseases
Assistant Professor of Pathology at the Stanford University Medical Center
Bio Dr. Howitt is a gynecologic and sarcoma pathologist, with academic interests in gynecologic mesenchymal tumors and morphologic and clinical correlates of molecular alterations in gynecologic neoplasia.
Michael Richard Howitt
Assistant Professor of Pathology
Current Research and Scholarly Interests Our lab is broadly interested in how intestinal microbes shape our immune system to promote both health and disease. Recently we discovered that a type of intestinal epithelial cell, called tuft cells, act as sentinels stationed along the lining of the gut. Tuft cells respond to microbes, including parasites, to initiate type 2 immunity, remodel the epithelium, and alter gut physiology. Surprisingly, these changes to the intestine rely on the same chemosensory pathway found in oral taste cells. Currently, we aim to 1) elucidate the role of specific tuft cell receptors in microbial detection. 2) To understand how protozoa and bacteria within the microbiota impact host immunity. 3) Discover how tuft cells modulate surrounding cells and tissue.
Chris C.S. Hsiung
Resident in Pathology
Bio Chris Hsiung, M.D., Ph.D., is a resident physician in Clinical Pathology at Stanford University School of Medicine. Chris completed his M.D. (2017) and Ph.D.(2016) in Cell and Molecular Biology through the Medical Scientist Training Program at the Perelman School of Medicine, University of Pennsylvania, where he was co-advised by Dr. Gerd Blobel and Dr. Arjun Raj. Chris's PhD work uncovered several molecular aspects of genome accessibility and transcriptional control during mitosis, lending insights into how transcriptional states are propagated despite microscopic chromosome condensation and transcriptional silencing during mitosis. Currently, Chris is interested in understanding the gene regulatory networks that underlie normal and diseased tissues, and applying the knowledge gained toward clinical diagnostics and therapeutics.