School of Medicine
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Postdoctoral Research Fellow, Developmental Biology
Current Research and Scholarly Interests Crossovers (COs) at meiosis are necessary for a balanced first meiotic division. The number of crossovers, per cell and per chromosome, is tightly regulated, within a narrow range of variation. COs are initiated by double strand-breaks (DSBs) that are then processed either through the ZMM pathway or the MUS81 pathway. But DSBs greatly outnumbers COs in a large set of species. This suggests a conserved mechanism which would limit the number of COs formed despite an excess of CO intermediates.