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Inner ear microendoscopy and prosthesis design -- Developing techniques for minimally-invasive imaging of inner ear microanatomy and neural pysiology. Applications include improved cochlear implant development, inner ear regenerative techniques, inner ear surgery, and auditory physiology. Collaboration with Mark Schnitzer PhD, Gerald Popelka PhD, Kwabena Boahen PhD.Microsurgical robotics -- Developing scalable microsurgical instrumentation and robotic techniques for use in head and neck surgery. Collaboration with Kenneth Salisbury, PhD.Surgical Simulation -- Developing immersive environment for simulation of ear and skull base surgery for training, technique assessment, and preoperative planning. Collaboration with Kenneth Salisbury, PhD.
Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment of Vestibular Schwannoma and Meningioma
This will be a multi-center, proof of concept phase 0 study to assess the suppression of
p-AKT in Vestibular Schwannoma (VS) and meningiomas by AR-42 in adult patients undergoing
tumor resection. AR-42 is a small molecule which crosses the blood brain barrier (BBB) in
rodents, but the investigators are not certain yet if it will penetrate human VS. Meningiomas
are outside the BBB, but seem to be unusually resistant to all current medical treatments.
The primary endpoint of the bioactivity of suppression of p-AKT by AR-42 was selected as drug
activity seems more informative than bioavailability. Our preclinical data and others have
shown dose dependent suppression of p-AKT by AR-42 in both VS and meningiomas.
Stanford is currently not accepting patients for this trial.
For more information, please contact SPECTRUM, .
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