Bio

Academic Appointments


Honors & Awards


  • Early Career Scientist, Howard Hughes Medical Institute (2009-2015)
  • Troland Award, National Academy of Sciences (2009)
  • McKnight Scholar Award, McKnight Endowment Fund (2006-2009)
  • CAREER Award, National Science Foundation (2006-2011)
  • Pew Scholar, Pew Charitable Trust (2004-2008)

Professional Education


  • Ph.D., Princeton, Neuroscience (1995)
  • Postdoc, M.I.T., Neuroscience

Research & Scholarship

Current Research and Scholarly Interests


We study neural mechanisms of visual-motor integration and the neural basis of cognition (e.g. attention). We study the activity of single neurons in visual and motor structures within the brain, examine how perturbing that activity affects neurons in other brain structures, and also how it affects the perceptual and motor performance of behaving animals. Questions currently addressed by our group include:

(1) How are the signals conveyed by visual cortical neurons used to guide eye movements?

(2) How does oculomotor feedback affect processing in visual cortex?

(3) What is the impact of planned movements on visual perception?

(4) What are the neural circuits and neural computations that control selective attention?

Our laboratory is also driven to develop more powerful approaches to systems-level neurobiological questions.

Teaching

2013-14 Courses


Postdoctoral Advisees


Publications

Journal Articles


  • A distinct contribution of the frontal eye field to the visual representation of saccadic targets. journal of neuroscience Noudoost, B., Clark, K. L., Moore, T. 2014; 34 (10): 3687-3698

    Abstract

    The responses of neurons within posterior visual cortex are enhanced when response field (RF) stimuli are targeted with saccadic eye movements. Although the motor-related activity within oculomotor structures seems a likely source of the enhancement, the origin of the modulation is unknown. We tested the role of the frontal eye field (FEF) in driving presaccadic modulation in area V4 by inactivating FEF neurons at retinotopically corresponding sites within the macaque monkey (Macaca mulatta) brain. As previously observed, FEF inactivation produced profound, and spatially specific, deficits in memory-guided saccades, and increased the latency, scatter, and duration of visually guided saccades. Despite the clear behavioral deficits, we found that rather than being eliminated or reduced by FEF inactivation, presaccadic enhancement of V4 activity was increased. FEF inactivation nonetheless diminished the stimulus discriminability of V4 visual responses both during fixation and in the presaccadic period. Thus, without input from the FEF, V4 neurons signaled more about the direction of saccades and less about the features of the saccadic target. In addition, FEF inactivation significantly increased the suppressive effects of non-RF stimuli on V4 activity. These results reveal multiple sources of presaccadic modulation in V4 and suggest that the FEF contributes uniquely to the presaccadic specification of visual target features.

    View details for DOI 10.1523/JNEUROSCI.3824-13.2014

    View details for PubMedID 24599467

  • Visual space is compressed in prefrontal cortex before eye movements. Nature Zirnsak, M., Steinmetz, N. A., Noudoost, B., Xu, K. Z., Moore, T. 2014; 507 (7493): 504-7

    Abstract

    We experience the visual world through a series of saccadic eye movements, each one shifting our gaze to bring objects of interest to the fovea for further processing. Although such movements lead to frequent and substantial displacements of the retinal image, these displacements go unnoticed. It is widely assumed that a primary mechanism underlying this apparent stability is an anticipatory shifting of visual receptive fields (RFs) from their presaccadic to their postsaccadic locations before movement onset. Evidence of this predictive 'remapping' of RFs has been particularly apparent within brain structures involved in gaze control. However, critically absent among that evidence are detailed measurements of visual RFs before movement onset. Here we show that during saccade preparation, rather than remap, RFs of neurons in a prefrontal gaze control area massively converge towards the saccadic target. We mapped the visual RFs of prefrontal neurons during stable fixation and immediately before the onset of eye movements, using multi-electrode recordings in monkeys. Following movements from an initial fixation point to a target, RFs remained stationary in retinocentric space. However, in the period immediately before movement onset, RFs shifted by as much as 18 degrees of visual angle, and converged towards the target location. This convergence resulted in a threefold increase in the proportion of RFs responding to stimuli near the target region. In addition, like in human observers, the population of prefrontal neurons grossly mislocalized presaccadic stimuli as being closer to the target. Our results show that RF shifts do not predict the retinal displacements due to saccades, but instead reflect the overriding perception of target space during eye movements.

    View details for DOI 10.1038/nature13149

    View details for PubMedID 24670771

  • Dissociable dopaminergic control of saccadic target selection and its implications for reward modulation PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Soltani, A., Noudoost, B., Moore, T. 2013; 110 (9): 3579-3584

    Abstract

    To investigate mechanisms by which reward modulates target selection, we studied the behavioral effects of perturbing dopaminergic activity within the frontal eye field (FEF) of monkeys performing a saccadic choice task and simulated the effects using a plausible cortical network. We found that manipulation of FEF activity either by blocking D1 receptors (D1Rs) or by stimulating D2 receptors (D2Rs) increased the tendency to choose targets in the response field of the affected site. However, the D1R manipulation decreased the tendency to repeat choices on subsequent trials, whereas the D2R manipulation increased that tendency. Moreover, the amount of shift in target selection resulting from the two manipulations correlated in opposite ways with the baseline stochasticity of choice behavior. Our network simulation results suggest that D1Rs influence target selection mainly through their effects on the strength of inputs to the FEF and on recurrent connectivity, whereas D2Rs influence the excitability of FEF output neurons. Altogether, these results reveal dissociable dopaminergic mechanisms influencing target selection and suggest how reward can influence adaptive choice behavior via prefrontal dopamine.

    View details for DOI 10.1073/pnas.1221236110

    View details for Web of Science ID 000315841900075

    View details for PubMedID 23401524

  • Selective Attention from Voluntary Control of Neurons in Prefrontal Cortex SCIENCE Schafer, R. J., Moore, T. 2011; 332 (6037): 1568-1571

    Abstract

    Animals can learn to voluntarily control neuronal activity within various brain areas through operant conditioning, but the relevance of that control to cognitive functions is unknown. We found that rhesus monkeys can control the activity of neurons within the frontal eye field (FEF), an oculomotor area of the prefrontal cortex. However, operantly driven FEF activity was primarily associated with selective visual attention, and not oculomotor preparation. Attentional effects were untrained and were observed both behaviorally and neurophysiologically. Furthermore, selective attention correlated with voluntary, but not spontaneous, fluctuations in FEF activity. Our results reveal a specific association of voluntarily driven neuronal activity with "top-down" attention and suggest a basis for the use of neurofeedback training to treat disorders of attention.

    View details for DOI 10.1126/science.1199892

    View details for Web of Science ID 000291990000048

    View details for PubMedID 21617042

  • Control of visual cortical signals by prefrontal dopamine NATURE Noudoost, B., Moore, T. 2011; 474 (7351): 372-375

    Abstract

    The prefrontal cortex is thought to modulate sensory signals in posterior cortices during top-down attention, but little is known about the underlying neural circuitry. Experimental and clinical evidence indicate that prefrontal dopamine has an important role in cognitive functions, acting predominantly through D1 receptors. Here we show that dopamine D1 receptors mediate prefrontal control of signals in the visual cortex of macaques (Macaca mulatta). We pharmacologically altered D1-receptor-mediated activity in the frontal eye field of the prefrontal cortex and measured the effect on the responses of neurons in area V4 of the visual cortex. This manipulation was sufficient to enhance the magnitude, the orientation selectivity and the reliability of V4 visual responses to an extent comparable with the known effects of top-down attention. The enhancement of V4 signals was restricted to neurons with response fields overlapping the part of visual space affected by the D1 receptor manipulation. Altering either D1- or D2-receptor-mediated frontal eye field activity increased saccadic target selection but the D2 receptor manipulation did not enhance V4 signals. Our results identify a role for D1 receptors in mediating the control of visual cortical signals by the prefrontal cortex and suggest how processing in sensory areas could be altered in mental disorders involving prefrontal dopamine.

    View details for DOI 10.1038/nature09995

    View details for Web of Science ID 000291647100044

    View details for PubMedID 21572439

  • Latency of chromatic information in area V4. Journal of physiology, Paris Chang, M., Xian, S., Rubin, J., Moore, T. 2014; 108 (1): 11-17

    Abstract

    In the primate visual system, information about color is known to be carried in separate divisions of the retino-geniculo-cortical pathway. From the retina, responses of photoreceptors to short (S), medium (M), and long (L) wavelengths of light are processed in two different opponent pathways. Signals in the S-opponent pathway, or blue/yellow channel, have been found to lag behind signals in the L/M-opponent pathway, or red/green channel in primary visual area V1, and psychophysical studies have suggested similar perceptual delays. However, more recent psychophysical studies have found that perceptual differences are negligible with the proper controls, suggesting that information between the two channels is integrated at some stage of processing beyond V1. To study the timing of color signals further downstream in visual cortex, we examined the responses of neurons in area V4 to colored stimuli varying along the two cardinal axes of the equiluminant opponent color space. We used information theory to measure the mutual information between the stimuli presented and the neural responses in short time windows in order to estimate the latency of color information in area V4. We found that on average, despite the latency difference in V1, information about S-opponent signals arrives in V4 at the same time as information about L/M-opponent signals. This work indicates a convergence of signal timing among chromatic channels within extrastriate cortex.

    View details for DOI 10.1016/j.jphysparis.2013.05.006

    View details for PubMedID 23811158

  • Prefrontal contributions to visual selective attention. Annual review of neuroscience Squire, R. F., Noudoost, B., Schafer, R. J., Moore, T. 2013; 36: 451-466

    Abstract

    The faculty of attention endows us with the capacity to process important sensory information selectively while disregarding information that is potentially distracting. Much of our understanding of the neural circuitry underlying this fundamental cognitive function comes from neurophysiological studies within the visual modality. Past evidence suggests that a principal function of the prefrontal cortex (PFC) is selective attention and that this function involves the modulation of sensory signals within posterior cortices. In this review, we discuss recent progress in identifying the specific prefrontal circuits controlling visual attention and its neural correlates within the primate visual system. In addition, we examine the persisting challenge of precisely defining how behavior should be affected when attentional function is lost.

    View details for DOI 10.1146/annurev-neuro-062111-150439

    View details for PubMedID 23841841

  • Parietal and prefrontal neurons driven to distraction NATURE NEUROSCIENCE Noudoost, B., Moore, T. 2013; 16 (1): 8-9

    View details for DOI 10.1038/nn.3291

    View details for Web of Science ID 000312633900005

    View details for PubMedID 23257928

  • Persistent Spatial Information in the Frontal Eye Field during Object-Based Short-Term Memory JOURNAL OF NEUROSCIENCE Clark, K. L., Noudoost, B., Moore, T. 2012; 32 (32): 10907-10914

    Abstract

    Spatial attention is known to gate entry into visual short-term memory, and some evidence suggests that spatial signals may also play a role in binding features or protecting object representations during memory maintenance. To examine the persistence of spatial signals during object short-term memory, the activity of neurons in the frontal eye field (FEF) of macaque monkeys was recorded during an object-based delayed match-to-sample task. In this task, monkeys were trained to remember an object image over a brief delay, regardless of the locations of the sample or target presentation. FEF neurons exhibited visual, delay, and target period activity, including selectivity for sample location and target location. Delay period activity represented the sample location throughout the delay, despite the irrelevance of spatial information for successful task completion. Furthermore, neurons continued to encode sample position in a variant of the task in which the matching stimulus never appeared in their response field, confirming that FEF maintains sample location independent of subsequent behavioral relevance. FEF neurons also exhibited target-position-dependent anticipatory activity immediately before target onset, suggesting that monkeys predicted target position within blocks. These results show that FEF neurons maintain spatial information during short-term memory, even when that information is irrelevant for task performance.

    View details for DOI 10.1523/JNEUROSCI.1450-12.2012

    View details for Web of Science ID 000307640000012

    View details for PubMedID 22875925

  • Lumping and Splitting the Neural Circuitry of Visual Attention NEURON Steinmetz, N. A., Moore, T. 2012; 73 (3): 410-412

    Abstract

    Shifts of gaze and of covert attention rely on tightly linked yet divergent neural mechanisms. In this issue of Neuron, Gregoriou et al. (2012) provide interesting evidence that different functional classes of neurons within the frontal eye field contribute uniquely to these two functions.

    View details for DOI 10.1016/j.neuron.2012.01.011

    View details for Web of Science ID 000300140600003

    View details for PubMedID 22325195

  • Dissociation of Response Variability from Firing Rate Effects in Frontal Eye Field Neurons during Visual Stimulation, Working Memory, and Attention JOURNAL OF NEUROSCIENCE Chang, M. H., Armstrong, K. M., Moore, T. 2012; 32 (6): 2204-2216

    Abstract

    Recent studies suggest that trial-to-trial variability of neuronal spiking responses may provide important information about behavioral state. Observed changes in variability during sensory stimulation, attention, motor preparation, and visual discrimination suggest that variability may reflect the engagement of neurons in a behavioral task. We examined changes in spiking variability of frontal eye field (FEF) neurons in a change detection task requiring monkeys to remember a visually cued location and direct attention to that location while ignoring distracters elsewhere. In this task, the firing rates (FRs) of FEF neurons not only continuously reflect the location of the remembered cue and select targets, but also predict detection performance on a trial-by-trial basis. Changes in FEF response variability, as measured by the Fano factor (FF), showed clear dissociations from changes in FR. The FF declined in response to visual stimulation at all tested locations, even in the opposite hemifield, indicating much broader spatial tuning of the FF compared with the FR. Furthermore, despite robust spatial modulation of the FR throughout all epochs of the task, spatial tuning of the FF did not persist throughout the delay period, nor did it show attentional modulation. These results indicate that changes in variability, at least in the FEF, are most effectively driven by visual stimulation, while behavioral engagement is not sufficient. Instead, changes in variability may reflect shifts in the balance between feedforward and recurrent sources of excitatory drive.

    View details for DOI 10.1523/JNEUROSCI.2967-11.2012

    View details for Web of Science ID 000300207900030

    View details for PubMedID 22323732

  • The role of neuromodulators in selective attention TRENDS IN COGNITIVE SCIENCES Noudoost, B., Moore, T. 2011; 15 (12): 585-591

    Abstract

    Several classes of neurotransmitters exert modulatory effects on a broad and diverse population of neurons throughout the brain. Some of these neuromodulators, especially acetylcholine and dopamine, have long been implicated in the neural control of selective attention. We review recent evidence and evolving ideas about the importance of these neuromodulatory systems in attention, particularly visual selective attention. We conclude that, although our understanding of their role in the neural circuitry of selective attention remains rudimentary, recent research has begun to suggest unique contributions of neuromodulators to different forms of attention, such as bottom-up and top-down attention.

    View details for DOI 10.1016/j.tics.2011.10.006

    View details for Web of Science ID 000298127900005

    View details for PubMedID 22074811

  • Probing neural circuitry and function with electrical microstimulation PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES Clark, K. L., Armstrong, K. M., Moore, T. 2011; 278 (1709): 1121-1130

    Abstract

    Since the discovery of the nervous system's electrical excitability more than 200 years ago, neuroscientists have used electrical stimulation to manipulate brain activity in order to study its function. Microstimulation has been a valuable technique for probing neural circuitry and identifying networks of neurons that underlie perception, movement and cognition. In this review, we focus on the use of stimulation in behaving primates, an experimental system that permits causal inferences to be made about the effect of stimulation-induced activity on the resulting behaviour or neural signals elsewhere in the brain.

    View details for DOI 10.1098/rspb.2010.2211

    View details for Web of Science ID 000288241300001

    View details for PubMedID 21247952

  • A reliable microinjectrode system for use in behaving monkeys JOURNAL OF NEUROSCIENCE METHODS Noudoost, B., Moore, T. 2011; 194 (2): 218-223

    Abstract

    We describe a modified system for the precise delivery of small volumes of drugs to brain sites of behaving monkeys during simultaneous single-neuron electrophysiology. The system combines a conventional microelectrode for recording single neurons and a small gauge microsyringe in a durable design. It incorporates newly available microfluidic components to achieve high-precision fluidic control. The system is inexpensive, reusable and easy to fabricate; it minimizes neural tissue damage and achieves reliable single-neuron recordings at the injection site.

    View details for DOI 10.1016/j.jneumeth.2010.10.009

    View details for Web of Science ID 000289923100003

    View details for PubMedID 20951736

  • Top-down control of visual attention CURRENT OPINION IN NEUROBIOLOGY Noudoost, B., Chang, M. H., Steinmetz, N. A., Moore, T. 2010; 20 (2): 183-190

    Abstract

    Top-down visual attention improves perception of selected stimuli and that improvement is reflected in the neural activity at many stages throughout the visual system. Recent studies of top-down attention have elaborated on the signatures of its effects within visual cortex and have begun identifying its causal basis. Evidence from these studies suggests that the correlates of spatial attention exhibited by neurons within the visual system originate from a distributed network of structures involved in the programming of saccadic eye movements. We summarize this evidence and discuss its relationship to the neural mechanisms of spatial working memory.

    View details for DOI 10.1016/j.conb.2010.02.003

    View details for Web of Science ID 000278258900008

    View details for PubMedID 20303256

  • Stimulus onset quenches neural variability: a widespread cortical phenomenon NATURE NEUROSCIENCE Churchland, M. M., Yu, B. M., Cunningham, J. P., Sugrue, L. P., Cohen, M. R., Corrado, G. S., Newsome, W. T., Clark, A. M., Hosseini, P., Scott, B. B., Bradley, D. C., Smith, M. A., Kohn, A., Movshon, J. A., Armstrong, K. M., Moore, T., Chang, S. W., Snyder, L. H., Lisberger, S. G., Priebe, N. J., Finn, I. M., Ferster, D., Ryu, S. I., Santhanam, G., Sahani, M., Shenoy, K. V. 2010; 13 (3): 369-U25

    Abstract

    Neural responses are typically characterized by computing the mean firing rate, but response variability can exist across trials. Many studies have examined the effect of a stimulus on the mean response, but few have examined the effect on response variability. We measured neural variability in 13 extracellularly recorded datasets and one intracellularly recorded dataset from seven areas spanning the four cortical lobes in monkeys and cats. In every case, stimulus onset caused a decline in neural variability. This occurred even when the stimulus produced little change in mean firing rate. The variability decline was observed in membrane potential recordings, in the spiking of individual neurons and in correlated spiking variability measured with implanted 96-electrode arrays. The variability decline was observed for all stimuli tested, regardless of whether the animal was awake, behaving or anaesthetized. This widespread variability decline suggests a rather general property of cortex, that its state is stabilized by an input.

    View details for DOI 10.1038/nn.2501

    View details for Web of Science ID 000274860100020

    View details for PubMedID 20173745

  • Changes in the Response Rate and Response Variability of Area V4 Neurons During the Preparation of Saccadic Eye Movements JOURNAL OF NEUROPHYSIOLOGY Steinmetz, N. A., Moore, T. 2010; 103 (3): 1171-1178

    Abstract

    The visually driven responses of macaque area V4 neurons are modulated during the preparation of saccadic eye movements, but the relationship between presaccadic modulation in area V4 and saccade preparation is poorly understood. Recent neurophysiological studies suggest that the variability across trials of spiking responses provides a more reliable signature of motor preparation than mean firing rate across trials. We compared the dynamics of the response rate and the variability in the rate across trials for area V4 neurons during the preparation of visually guided saccades. As in previous reports, we found that the mean firing rate of V4 neurons was enhanced when saccades were prepared to stimuli within a neuron's receptive field (RF) in comparison with saccades to a non-RF location. Further, we found robust decreases in response variability prior to saccades and found that these decreases predicted saccadic reaction times for saccades both to RF and non-RF stimuli. Importantly, response variability predicted reaction time whether or not there were any accompanying changes in mean firing rate. In addition to predicting saccade direction, the mean firing rate could also predict reaction time, but only for saccades directed to the RF stimuli. These results demonstrate that response variability of area V4 neurons, like mean response rate, provides a signature of saccade preparation. However, the two signatures reflect complementary aspects of that preparation.

    View details for DOI 10.1152/jn.00689.2009

    View details for Web of Science ID 000275656200003

    View details for PubMedID 20018834

  • Selection and Maintenance of Spatial Information by Frontal Eye Field Neurons JOURNAL OF NEUROSCIENCE Armstrong, K. M., Chang, M. H., Moore, T. 2009; 29 (50): 15621-15629

    Abstract

    Voluntary attention is often allocated according to internally maintained goals. Recent evidence indicates that the frontal eye field (FEF) participates in the deployment of spatial attention, even in the absence of saccadic eye movements. In addition, many FEF neurons maintain persistent representations of impending saccades. However, the role of persistent activity in the general maintenance of spatial information, and its relationship to spatial attention, has not been explored. We recorded the responses of single FEF neurons in monkeys trained to remember cued locations in order to detect changes in targets embedded among distracters in a task that did not involve saccades. We found that FEF neurons persistently encoded the cued location throughout the trial during the delay period, when no visual stimuli were present, and during visual discrimination. Furthermore, FEF activity reliably predicted whether monkeys would detect the target change. Population analyses revealed that FEF neurons with persistent activity were more effective at selecting the target from among distracters than neurons lacking persistent activity. These results demonstrate that FEF neurons maintain spatial information in the absence of saccade preparation and suggest that this maintenance contributes to the selection of relevant visual stimuli.

    View details for DOI 10.1523/JNEUROSCI.4465-09.2009

    View details for Web of Science ID 000272837000002

    View details for PubMedID 20016076

  • Influence and Limitations of Popout in the Selection of Salient Visual Stimuli by Area V4 Neurons JOURNAL OF NEUROSCIENCE Burrows, B. E., Moore, T. 2009; 29 (48): 15169-15177

    Abstract

    The neural mechanism of bottom-up attention and its relationship to top-down attention are poorly understood. Visual stimuli that differ from others in their component features are salient and tend to draw attention in a bottom-up manner. "Popout" stimuli differ uniformly from surrounding items and are more easily detected than stimuli composed of a conjunction of surrounding features. We compared the responses of single area V4 neurons to popout and conjunction stimuli appearing within the classical receptive field (CRF) and found that their responses are modulated by popout. This selectivity was more robust when larger numbers of surrounding items and multiple features were included in the display, and it was absent when only a few items were presented immediately outside the CRF. In addition, the popout modulation of V4 activity was eliminated when top-down attention was directed to locations outside of the CRFs during saccade preparation, indicating that the salience of popout stimuli is not sufficient to drive selection by V4 neurons. These results demonstrate that neurons in feature-selective cortex are influenced by bottom-up attention, but that this influence is limited by top-down attention.

    View details for DOI 10.1523/JNEUROSCI.3710-09.2009

    View details for Web of Science ID 000272361700017

    View details for PubMedID 19955369

  • Dynamic sensitivity of area V4 neurons during saccade preparation PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Han, X., Xian, S. X., Moore, T. 2009; 106 (31): 13046-13051

    Abstract

    During the preparation of saccadic eye movements, visual attention is confined to the target of intended fixation and there is a corresponding diminution of visual sensitivity at nontarget locations. Neurons within the macaque visual cortex exhibit correlates of these perceptual changes, such as in area V4, where neuronal responses are enhanced during the preparation of saccades to stimuli within the receptive field (RF), and responses are suppressed during the preparation of saccades to other locations. Both the perceptual and neurophysiological effects suggest that the sensitivity of visual cortical neurons to input is dynamic during saccade preparation. We probed the contrast sensitivity of area V4 neurons to nontarget stimuli at varying times during the preparation of saccades to locations outside of the neuron's receptive field. We found that the contrast sensitivity of many neurons is profoundly altered within 50 ms of saccade onset. The luminance or color contrast sensitivity of individual V4 neurons could increase, decrease, or remain unchanged before saccade onset. For luminance contrast sensitivity, decreases in sensitivity were more frequent and larger in magnitude, resulting in an overall decrement in sensitivity across the population. For color contrast, the effects were smaller and more heterogeneous, resulting in little or no overall change in sensitivity across the population. Our results demonstrate the dynamic influence that saccade preparation has on the sensitivity of visual cortical neurons and suggest a basis for the changes in perception known to occur during saccade preparation.

    View details for DOI 10.1073/pnas.0902412106

    View details for Web of Science ID 000268667600086

    View details for PubMedID 19622736

  • Presaccadic discrimination of receptive field stimuli by area V4 neurons VISION RESEARCH Moore, T., Chang, M. H. 2009; 49 (10): 1227-1232

    Abstract

    Previous studies have shown that the visual responses of neurons in extrastriate area V4 are enhanced prior to saccadic eye movements that target receptive field (RF) stimuli. We used receiver-operator characteristic (ROC) analysis to quantify how well V4 neurons could discriminate stable RF stimuli targeted by visually-guided saccades or ignored during saccades elsewhere. We found that discrimination was transiently enhanced prior to saccades to RF stimuli whereas it was reduced prior to saccades elsewhere. Similar to what is observed during covert attention and after frontal eye field microstimulation, the changes in stimulus discrimination were due in part to changes in response magnitude. In addition, we found evidence of an increased reliability of responses when saccades were made to the RF stimulus. These results highlight the similarity of mechanisms driving covert spatial attention and the preparation of visually-guided saccades.

    View details for DOI 10.1016/j.visres.2008.03.018

    View details for Web of Science ID 000267168800018

    View details for PubMedID 18501949

  • Attention governs action in the primate frontal eye field NEURON Schafer, R. J., Moore, T. 2007; 56 (3): 541-551

    Abstract

    While the motor and attentional roles of the frontal eye field (FEF) are well documented, the relationship between them is unknown. We exploited the known influence of visual motion on the apparent positions of targets, and measured how this illusion affects saccadic eye movements during FEF microstimulation. Without microstimulation, saccades to a moving grating are biased in the direction of motion, consistent with the apparent position illusion. Here we show that microstimulation of spatially aligned FEF representations increases the influence of this illusion on saccades. Rather than simply impose a fixed-vector signal, subthreshold stimulation directed saccades away from the FEF movement field, and instead more strongly in the direction of visual motion. These results demonstrate that the attentional effects of FEF stimulation govern visually guided saccades, and suggest that the two roles of the FEF work together to select both the features of a target and the appropriate movement to foveate it.

    View details for DOI 10.1016/j.neuron.2007.09.029

    View details for Web of Science ID 000250774600012

    View details for PubMedID 17988636

  • Electrical signals propagate unbiased in cortex NEURON Gilja, V., Moore, T. 2007; 55 (5): 684-686

    Abstract

    The greater spatial coherence of local field potentials (LFPs) compared with that of spiking activity has been attributed to frequency-dependent propagation of signals through the cortical medium. However, in this issue of Neuron, Logothetis and colleagues show that signal propagation within cortex is largely unbiased across different frequencies, thus suggesting a more functional and interpretable basis of LFP coherence.

    View details for DOI 10.1016/j.neuron.2007.08.012

    View details for Web of Science ID 000249857000004

    View details for PubMedID 17785175

  • Temporal patterning of saccadic eye movement signals JOURNAL OF NEUROSCIENCE Kimmel, D. L., Moore, T. 2007; 27 (29): 7619-7630

    Abstract

    Electrical microstimulation is used widely in experimental neurophysiology to examine causal links between specific brain areas and their behavioral functions and is used clinically to treat neurological and psychiatric disorders in patients. Typically, microstimulation is applied to local brain regions as a train of equally spaced current pulses. We were interested in the sensitivity of a neural circuit to a train of variably spaced pulses, as is observed in physiological spike trains. We compared the effect of fixed, decelerating, accelerating, and randomly varying microstimulation patterns on the likelihood and metrics of eye movements evoked from the frontal eye field of monkeys, while holding the mean interpulse interval constant. Our results demonstrate that the pattern of microstimulation pulses strongly influences the probability of evoking a saccade, as well as the metrics of the saccades themselves. Specifically, the pattern most closely resembling physiological spike trains (accelerating pattern) was most effective at evoking a saccade, three times more so than the least effective decelerating pattern. A saccade-triggered average of effective random trains confirmed the positive relationship between accelerating rate and efficacy. These results have important implications for the use of electrical microstimulation in both experimental and clinical settings and suggest a means to study the role of temporal pattern in the encoding of behavioral and cognitive functions.

    View details for DOI 10.1523/JNEUROSCI.0386-07.2007

    View details for Web of Science ID 000248177900001

    View details for PubMedID 17634356

  • Rapid enhancement of visual cortical response discriminability by microstimulation of the frontal eye field PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Armstrong, K. M., Moore, T. 2007; 104 (22): 9499-9504

    Abstract

    Visual attention provides a means of selecting among the barrage of information reaching the retina and of enhancing the perceptual discriminability of relevant stimuli. Neurophysiological studies in monkeys and functional imaging studies in humans have demonstrated neural correlates of these perceptual improvements in visual cortex during attention. Importantly, voluntary attention improves the discriminability of visual cortical responses to relevant stimuli. Recent work aimed at identifying sources of attentional modulation has implicated the frontal eye field (FEF) in driving spatial attention. Subthreshold microstimulation of the FEF enhances the responses of area V4 neurons to spatially corresponding stimuli. However, it is not known whether these enhancements include improved visual-response discriminability, a hallmark of voluntary attention. We used receiver-operator characteristic analysis to quantify how well V4 responses discriminated visual stimuli and examined how discriminability was affected by FEF microstimulation. Discriminability of responses to stable visual stimuli decayed over time but was transiently restored after microstimulation of the FEF. As observed during voluntary attention, the enhancement resulted only from changes in the magnitude of V4 responses and not in the relationship between response magnitude and variance. Enhanced response discriminability was apparent immediately after microstimulation and was reliable within 40 ms of microstimulation onset, indicating a direct influence of FEF stimulation on visual representations. These results contribute to the mounting evidence that saccade-related signals are a source of spatial attentive selection.

    View details for DOI 10.1073/pnas.0701104104

    View details for Web of Science ID 000246935700074

    View details for PubMedID 17517599

  • Changes in visual receptive fields with microstimulation of frontal cortex NEURON Armstrong, K. M., Fitzgerald, J. K., Moore, T. 2006; 50 (5): 791-798

    Abstract

    The influence of attention on visual cortical neurons has been described in terms of its effect on the structure of receptive fields (RFs), where multiple stimuli compete to drive neural responses and ultimately behavior. We stimulated the frontal eye field (FEF) of passively fixating monkeys and produced changes in V4 responses similar to known effects of voluntary attention. Subthreshold FEF stimulation enhanced visual responses at particular locations within the RF and altered the interaction between pairs of RF stimuli to favor those aligned with the activated FEF site. Thus, we could influence which stimulus drove the responses of individual V4 neurons. These results suggest that spatial signals involved in saccade preparation are used to covertly select among multiple stimuli appearing within the RFs of visual cortical neurons.

    View details for DOI 10.1016/j.neuron.2006.05.010

    View details for Web of Science ID 000238165000013

    View details for PubMedID 16731516

  • The neurobiology of visual attention: finding sources CURRENT OPINION IN NEUROBIOLOGY Moore, T. 2006; 16 (2): 159-165

    Abstract

    The profusion of progress during the past twenty years in identifying neural correlates of selective attention within the visual system has left open the question of how visual representations are biased to favor target stimuli. Studies aimed at specifying the mechanisms that can be causally implicated in the control of visual selective attention have only recently begun in earnest. Employing both the psychophysical and the neuroanatomical data, recent neurophysiological experiments in monkeys and neuroimaging studies in humans are converging on the neural circuits that provide the source of at least some forms of attentional control signals.

    View details for DOI 10.1016/j.conb.2006.03.009

    View details for Web of Science ID 000237234700006

    View details for PubMedID 16563729

  • Visual and oculomotor selection: links, causes and implications for spatial attention TRENDS IN COGNITIVE SCIENCES Awh, E., Armstrong, K. M., Moore, T. 2006; 10 (3): 124-130

    Abstract

    Natural scenes contain far more information than can be processed simultaneously. Thus, our visually guided behavior depends crucially on the capacity to attend to relevant stimuli. Past studies have provided compelling evidence of functional overlap of the neural mechanisms that control spatial attention and saccadic eye movements. Recent neurophysiological work demonstrates that the neural circuits involved in the preparation of saccades also play a causal role in directing covert spatial attention. At the same time, other studies have identified separable neural populations that contribute uniquely to visual and oculomotor selection. Taken together, all of the recent work suggests how visual and oculomotor signals are integrated to simultaneously select the visual attributes of targets and the saccades needed to fixate them.

    View details for DOI 10.1016/j.tics.2006.01.001

    View details for Web of Science ID 000236533800010

    View details for PubMedID 16469523

  • Representations of faces and body parts in macaque temporal cortex: A functional MRI study PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Pinsk, M. A., DeSimone, K., Moore, T., Gross, C. G., Kastner, S. 2005; 102 (19): 6996-7001

    Abstract

    Human neuroimaging studies suggest that areas in temporal cortex respond preferentially to certain biologically relevant stimulus categories such as faces and bodies. Single-cell studies in monkeys have reported cells in inferior temporal cortex that respond selectively to faces, hands, and bodies but provide little evidence of large clusters of category-specific cells that would form "areas." We probed the category selectivity of macaque temporal cortex for representations of monkey faces and monkey body parts relative to man-made objects using functional MRI in animals trained to fixate. Two face-selective areas were activated bilaterally in the posterior and anterior superior temporal sulcus exhibiting different degrees of category selectivity. The posterior face area was more extensively activated in the right hemisphere than in the left hemisphere. Immediately adjacent to the face areas, regions were activated bilaterally responding preferentially to body parts. Our findings suggest a category-selective organization for faces and body parts in macaque temporal cortex.

    View details for DOI 10.1073/pnas.0502605102

    View details for Web of Science ID 000229048500064

    View details for PubMedID 15860578

  • Methods for functional magnetic resonance imaging in normal and lesioned behaving monkeys JOURNAL OF NEUROSCIENCE METHODS Pinsk, M. A., Moore, T., Richter, M. C., Gross, C. G., Kastner, S. 2005; 143 (2): 179-195

    Abstract

    Methods for performing functional magnetic resonance imaging (fMRI) studies in behaving and lesioned monkeys using a human MR scanner are reported. Materials for head implant surgery were selected based on tests for magnetic susceptibility. A primate chair with a rigid head fixation system and a mock scanner environment for training were developed. To perform controlled visual studies, monkeys were trained to maintain fixation for several minutes using a novel training technique that utilized continuous juice rewards. A surface coil was used to acquire anatomical and functional images in four monkeys, one with a partial lesion of striate cortex. High-resolution anatomical images were used after non-uniform intensity correction to create cortical surface reconstructions of both lesioned and normal hemispheres. Our methods were confirmed in two visual experiments, in which functional activations were obtained during both free viewing and fixation conditions. In one experiment, face-selective activity was found in the fundus and banks of the superior temporal sulcus and the middle temporal gyrus in monkeys viewing pictures of faces and objects while maintaining fixation. In a second experiment, regions in occipital, parietal, and frontal cortex were activated in lesioned and normal animals viewing a cartoon movie. Importantly, in the animal with the striate lesion, fMRI signals were obtained in the immediate vicinity of the lesion. Our results extend those previously reported by providing a detailed account of the technique and by demonstrating the feasibility of fMRI in monkeys with lesions.

    View details for DOI 10.1016/j.jneumeth.2004.10.003

    View details for Web of Science ID 000228708900011

    View details for PubMedID 15814151

  • Homeland defense begins in precentral cortex. Focus on "Sensorimotor integration in the precentral gyrus: Polysensory neurons and defensive movements" JOURNAL OF NEUROPHYSIOLOGY Moore, T. 2004; 91 (4): 1456-1456

    View details for DOI 10.1152/jn.01085.2003

    View details for Web of Science ID 000220086100002

    View details for PubMedID 15010494

  • Distribution of hand location in monkeys during spontaneous behavior EXPERIMENTAL BRAIN RESEARCH Graziano, M. S., Cooke, D. F., Taylor, C. S., Moore, T. 2004; 155 (1): 30-36

    Abstract

    Recently it was shown that electrical stimulation of the precentral gyrus of monkeys can evoke complex, coordinated movements. In the forelimb representation, stimulation of each site caused the arm to move to a specific final posture, and thus the hand to move to a location in space. Among these stimulation-evoked hand locations, certain regions of the hand's workspace were more represented than others. We hypothesized that a similar non-uniform distribution of hand location should be present during a monkey's spontaneous behavior. The present study examined the distribution of hand location of monkeys in their home cages. This distribution was similar to that found by stimulation of the precentral gyrus. That is, arm postures that were over-represented in spontaneous behavior were also over-represented in the movements evoked by cortical stimulation.

    View details for DOI 10.1007/s00221-003-1701-4

    View details for Web of Science ID 000189201900005

    View details for PubMedID 15064882

  • Visually guided behavior after V1 lesions in young and adult monkeys and its relation to blindsight in humans. Progress in brain research Gross, C. G., Moore, T., Rodman, H. R. 2004; 144: 279-294

    Abstract

    After lesions of striate cortex in primates, there is still the capacity to detect and localize visual stimuli. In this chapter we review three aspects of our study of this phenomenon in macaques. First, we found that macaques that received their striate lesions as infants had considerably greater ability to detect and localize stimuli than those that received similar lesions as adults. Second, we suggest that the visual functions that survive striate lesions in macaques made in adulthood resemble those in human 'blindsight'. Third, we report that monkeys with striate lesions made in infancy are able to discriminate direction of visual motion.

    View details for PubMedID 14650855

  • Microstimulation of the frontal eye field and its effects on covert spatial attention JOURNAL OF NEUROPHYSIOLOGY Moore, T., Fallah, M. 2004; 91 (1): 152-162

    Abstract

    Many studies have established that the strength of visual perception and the strength of visual representations within visual cortex vary according to the focus of covert spatial attention. While it is clear that attention can modulate visual signals, the source of this modulation remains unknown. We have examined the possibility that saccade related mechanisms provide a source of spatial attention by studying the effects of electrical microstimulation of the frontal eye fields (FEF) on spatial attention. Monkeys performed a task in which they had to detect luminance changes of a peripheral target while ignoring a flashing distracter. The target luminance change could be preceded by stimulation of the FEF at current levels below that which evoked saccadic eye movements. We found that when the target change was preceded by stimulation of FEF, the monkey could detect smaller changes in target luminance. The increased sensitivity to the target change only occurred when the target was placed in the part of the visual field represented by neurons at the stimulation site. The magnitude of improvement depended on the temporal asynchrony of the stimulation onset and the target event. No significant effect of stimulation was observed when long intervals (>300 ms) between stimulation and the target event were used, and the magnitude of the increased sensitivity decreased systematically with increasing asynchrony. At the shortest asynchrony, FEF stimulation temporally overlapped the target event and the magnitude of the improvement was comparable to that of removing the distracter from the task. These results demonstrate that transient, but potent improvements in the deployment of covert spatial attention can be obtained by microstimulation of FEF sites from which saccadic eye movements are also evoked.

    View details for DOI 10.1152/jn.00741.2002

    View details for Web of Science ID 000187964500013

    View details for PubMedID 13679398

  • Visuomotor origins of covert spatial attention NEURON Moore, T., Armstrong, K. M., Fallah, M. 2003; 40 (4): 671-683

    Abstract

    Covert spatial attention produces biases in perceptual performance and neural processing of behaviorally relevant stimuli in the absence of overt orienting movements. The neural mechanism that gives rise to these effects is poorly understood. This paper surveys past evidence of a relationship between oculomotor control and visual spatial attention and more recent evidence of a causal link between the control of saccadic eye movements by frontal cortex and covert visual selection. Both suggest that the mechanism of covert spatial attention emerges as a consequence of the reciprocal interactions between neural circuits primarily involved in specifying the visual properties of potential targets and those involved in specifying the movements needed to fixate them.

    View details for Web of Science ID 000186651200004

    View details for PubMedID 14622573

  • Complex movements evoked by microstimulation of the ventral intraparietal area PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Cooke, D. F., Taylor, C. S., Moore, T., Graziano, M. S. 2003; 100 (10): 6163-6168

    Abstract

    Most neurons in the ventral intraparietal area (VIP) of the macaque brain respond to both visual and tactile stimuli. The tactile receptive field is usually on the face, and the visual receptive field usually corresponds spatially to the tactile receptive field. In this study, electrical microstimulation of VIP, but not of surrounding tissue, caused a constellation of movements including eye closure, facial grimacing, head withdrawal, elevation of the shoulder, and movements of the hand to the space beside the head or shoulder. A similar set of movements was evoked by an air puff to the monkey's cheek. One interpretation is that VIP contributes to defensive movements triggered by stimuli on or near the head.

    View details for Web of Science ID 000182939400106

    View details for PubMedID 12719522

  • Selective gating of visual signals by microstimulation of frontal cortex NATURE Moore, T., Armstrong, K. M. 2003; 421 (6921): 370-373

    Abstract

    Several decades of psychophysical and neurophysiological studies have established that visual signals are enhanced at the locus of attention. What remains a mystery is the mechanism that initiates biases in the strength of visual representations. Recent evidence argues that, during spatial attention, these biases reflect nascent saccadic eye movement commands. We examined the functional interaction of saccade preparation and visual coding by electrically stimulating sites within the frontal eye fields (FEF) and measuring its effect on the activity of neurons in extrastriate visual cortex. Here we show that visual responses in area V4 could be enhanced after brief stimulation of retinotopically corresponding sites within the FEF using currents below that needed to evoke saccades. The magnitude of the enhancement depended on the effectiveness of receptive field stimuli as well as on the presence of competing stimuli outside the receptive field. Stimulation of non-corresponding FEF representations could suppress V4 responses. The results suggest that the gain of visual signals is modified according to the strength of spatially corresponding eye movement commands.

    View details for DOI 10.1038/nature01341

    View details for Web of Science ID 000180533000042

    View details for PubMedID 12540901

  • The cortical control of movement revisited NEURON Graziano, M. S., Taylor, C. S., Moore, T., Cooke, D. F. 2002; 36 (3): 349-362

    Abstract

    Recently, we found that electrical stimulation of motor cortex caused monkeys to make coordinated, complex movements. These evoked movements were arranged across the cortex in a map of spatial locations to which the hand moved. We suggest that some of the subdivisions previously described within primary motor and premotor cortex may represent different types of actions that monkeys tend to make in different regions of space. According to this view, primary and premotor cortex may fit together into a larger map of manual space.

    View details for Web of Science ID 000178877700006

    View details for PubMedID 12408840

  • Probing cortical function with electrical stimulation NATURE NEUROSCIENCE Graziano, M. S., Taylor, C. S., Moore, T. 2002; 5 (10): 921-921

    View details for DOI 10.1038/nn1002-921

    View details for Web of Science ID 000178242200004

    View details for PubMedID 12352975

  • Complex movements evoked by microstimulation of precentral cortex NEURON Graziano, M. S., Taylor, C. S., Moore, T. 2002; 34 (5): 841-851

    Abstract

    Electrical microstimulation was used to study primary motor and premotor cortex in monkeys. Each stimulation train was 500 ms in duration, approximating the time scale of normal reaching and grasping movements and the time scale of the neuronal activity that normally accompanies movement. This stimulation on a behaviorally relevant time scale evoked coordinated, complex postures that involved many joints. For example, stimulation of one site caused the mouth to open and also caused the hand to shape into a grip posture and move to the mouth. Stimulation of this site always drove the joints toward this final posture, regardless of the direction of movement required to reach the posture. Stimulation of other cortical sites evoked different postures. Postures that involved the arm were arranged across cortex to form a map of hand positions around the body. This stimulation-evoked map encompassed both primary motor and the adjacent premotor cortex. We suggest that these regions fit together into a single map of the workspace around the body.

    View details for Web of Science ID 000175951800017

    View details for PubMedID 12062029

  • Eye movements modulate visual receptive fields of V4 neurons NEURON Tolias, A. S., Moore, T., Smirnakis, S. M., Tehovnik, E. J., Siapas, A. G., Schiller, P. H. 2001; 29 (3): 757-767

    Abstract

    The receptive field, defined as the spatiotemporal selectivity of neurons to sensory stimuli, is central to our understanding of the neuronal mechanisms of perception. However, despite the fact that eye movements are critical during normal vision, the influence of eye movements on the structure of receptive fields has never been characterized. Here, we map the receptive fields of macaque area V4 neurons during saccadic eye movements and find that receptive fields are remarkably dynamic. Specifically, before the initiation of a saccadic eye movement, receptive fields shrink and shift towards the saccade target. These spatiotemporal dynamics may enhance information processing of relevant stimuli during the scanning of a visual scene, thereby assisting the selection of saccade targets and accelerating the analysis of the visual scene during free viewing.

    View details for Web of Science ID 000167868900024

    View details for PubMedID 11301034

  • Control of eye movements and spatial attention PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Moore, T., Fallah, M. 2001; 98 (3): 1273-1276

    Abstract

    Several lines of evidence suggest that planning eye movements and directing visuospatial attention share overlapping brain mechanisms. This study tested whether spatial attention can be enhanced by altering oculomotor signals within the brain. Monkeys performed a spatial attention task while neurons within the frontal eye field, an oculomotor area within prefrontal cortex, were electrically stimulated below the level at which eye movements are evoked. We found that we could improve the monkey's performance with microstimulation when, but only when, the object to be attended was positioned in the space represented by the cortical stimulation site.

    View details for Web of Science ID 000166807300091

    View details for PubMedID 11158629

  • Direction of motion discrimination after early lesions of striate cortex (V1) of the macaque monkey PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Moore, T., Rodman, H. R., Gross, C. G. 2001; 98 (1): 325-330

    Abstract

    Previous studies have established that humans and monkeys with damage to striate cortex are able to detect and localize bright targets within the resultant scotoma. Electrophysiological evidence in monkeys suggests that residual vision also might include sensitivity to direction of visual motion. We tested whether macaque monkeys with longstanding lesions of striate cortex (V1), sustained in infancy, could discriminate visual stimuli on the basis of direction of motion. Three monkeys with unilateral striate cortex lesions sustained in infancy were tested 2-5 years postlesion on a direction of motion discrimination task. Each monkey was trained to make saccadic eye movements to a field of moving dots or to withhold such eye movements, depending on the direction of motion in a coherent random dot display. With smaller motion displays, monkeys were unable to detect or discriminate motion within the scotoma, although they could discriminate moving from static stimuli. Yet, each monkey was able to discriminate direction of motion when the motion stimulus was larger, but still confined to the scotoma. The results demonstrate that the recovery after infant damage to striate cortex includes some sensitivity to direction of visual motion.

    View details for Web of Science ID 000166222600061

    View details for PubMedID 11134530

  • Shape representations and visual guidance sf saccadic eye movements SCIENCE Moore, T. 1999; 285 (5435): 1914-1917

    Abstract

    One hallmark of primate vision is that the direction of gaze is constantly shifting to position objects of interest appropriately on the fovea, where visual acuity is greatest. This process must involve the close cooperation of oculomotor and visual recognition mechanisms because visual details must be translated into specific motor commands. This paper describes the correspondence between the presaccadic activity of V4 neurons and the degree of visual guidance of saccadic eye movements to objects of different form. The results suggest that neurons that participate in coding visual stimuli are also involved in guiding the eyes to prominent features of objects.

    View details for Web of Science ID 000082638300051

    View details for PubMedID 10489371

  • Visual representations during saccadic eye movements PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Moore, T., Tolias, A. S., Schiller, P. H. 1998; 95 (15): 8981-8984

    Abstract

    In normal vision, shifts of attention are usually followed by saccadic eye movements. Neurons in extrastriate area V4 are modulated by focal attention when eye movements are withheld, but they also respond in advance of visually guided saccadic eye movements. We have examined the visual selectivity of saccade-related responses of area V4 neurons in monkeys making delayed eye movements to receptive field stimuli of varying orientation. This task did not require the monkey to attend to orientation per se but merely to foveate the receptive field stimulus. We present evidence that the presaccadic enhancement exhibited by V4 neurons, quite separate from the response at stimulus onset, is a resurgent visual representation that seems as selective as the response is when the stimulus first appears. The presaccadic enhancement appears to provide a strengthening of a decaying featural representation immediately before an eye movement is directed to visual targets. We suggest that this reactivation provides a mechanism by which a clear perception of the saccade goal can be maintained during the execution of the saccade, perhaps for the purpose of establishing continuity across eye movements.

    View details for Web of Science ID 000075143900101

    View details for PubMedID 9671790

  • Man, monkey, and blindsight NEUROSCIENTIST Moore, T., Rodman, H. R., Gross, C. G. 1998; 4 (4): 227-230
  • Man, Monkey and Blindsight. The Neuroscientist Moore, T., Rodman, H.R., Gross, C.G. 1998; 4: 227-230
  • Greater residual vision in monkeys after striate cortex damage in infancy JOURNAL OF NEUROPHYSIOLOGY Moore, T., Rodman, H. R., REPP, A. B., Gross, C. G., Mezrich, R. S. 1996; 76 (6): 3928-3933

    Abstract

    1. Monkeys with large unilateral surgical ablations of striate cortex, sustained either in adulthood or at 5-6 wk of age, were trained on an oculomotor detection and localization task and tested with visual stimuli in the hemifields ipsilateral and contralateral to the lesion 2-5 yr after surgery. 2. Monkeys with lesions sustained in adulthood were largely unable to detect stimuli in the hemifield contralateral to the lesion, with only one monkey showing recovery toward the end of testing. Monkeys with lesions of striate cortex made in infancy, however, each showed residual detection capacity at the beginning of testing and improved to near normal by the end of testing. 3. Each of the monkeys showing a residual ability to detect within the contralateral hemifield was also able to localize visual targets with eye movements. 4. These findings demonstrate that the vision surviving striate cortex damage in primates is more robust after early damage as has been shown to be the case for primary somatosensory, motor, and association cortex.

    View details for Web of Science ID A1996WA80300032

    View details for PubMedID 8985890

  • LOCALIZATION OF VISUAL-STIMULI AFTER STRIATE CORTEX DAMAGE IN MONKEYS - PARALLELS WITH HUMAN BLINDSIGHT PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Moore, T., Rodman, H. R., REPP, A. B., Gross, C. G. 1995; 92 (18): 8215-8218

    Abstract

    Blindsight is a phenomenon in which human patients with damage to striate cortex deny any visual sensation in the resultant visual field defect but can nonetheless detect and localize stimuli when persuaded to guess. Although monkeys with striate lesions have also been shown to exhibit some residual vision, it is not yet clear to what extent the residual capacities in monkeys parallel the phenomenon of human blindsight. To clarify this issue, we trained two monkeys with unilateral lesions of striate cortex to make saccadic eye movements to visual targets in both hemifields under two conditions. In the condition analogous to clinical perimetry, they failed to initiate saccades to targets presented in the contralateral hemifield and thus appeared "blind." Only in the condition where the fixation point was turned off simultaneously with the onset of the target--signaling the animal to respond at the appropriate time--were monkeys able to localize targets contralateral to the striate lesion. These results indicate that the conditions under which residual vision is demonstrable are similar for monkeys with striate cortex damage and humans with blindsight.

    View details for Web of Science ID A1995RR84400027

    View details for PubMedID 7667270

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