Current Research and Scholarly Interests
We study the molecular events that give rise to the sensation of touch and temperature using C. elegans nematodes as a model system. To do this, we use a combination of quantitative behavioral analysis, genetics, in vivo electrophysiology, CRISPR-mediated gene editiing, light and electron microscopy, and heterologous expression of ion channels. Additionally, we seek to better understand how sensory neurons withstand mechanical and chemical stresses, including chemotherapy drugs and elevated levels of glucose characeristic of diabetes.