Current Research and Scholarly Interests
My research is focused on developing and evaluating molecular imaging agents to improve the way we diagnose, treat, and understand brain diseases, with a particular focus on Alzheimer's disease (AD).
I am very interested in imaging neuroinflammation and neurodegeneration using positron emission tomography (PET). Non-invasive PET imaging of these processes will likely enhance our understanding of a range of brain disorders (including Alzheimers disease, multiple sclerosis, and stroke), and ultimately generate effective diagnostic and treatment strategies.
For over a decade, my research has involved designing and developing novel PET radioligands for different neurological targets, including the translocator protein (18kDa) (TSPO). Since TSPO expression reflects glial activation and neuroinflammation, radioligands for this protein may act as valuable tools for detecting regions of active brain disease before clinical signs manifest. These radioligands may also be used to track disease progression and monitor response to novel therapeutics.