Bio

Honors & Awards


  • Scholarship, research funding from Stanford University, (2016)
  • Fellowship, research funding from Brunel University London, selected among 27 candidates, (2015)
  • Scholarship, research funding from Oklahoma State University, (2014)
  • Best PhD Thesis winner, selected among graduated students between 2011 and 2014, (2014)

Professional Education


  • Postdoctoral Research Fellow, Stanford University, Regenerative Medicine
  • Postdoctoral Research Fellow, Brunel University London, Biomaterials (2016)
  • Research Scholar, Oklahoma State University, Biomaterials and Tissue Engineering (2014)
  • Doctor of Philosophy, Isfahan University Of Technology (2014)
  • Master of Science, Isfahan University Of Technology (2011)
  • Bachelor of Science, Isfahan University Of Technology (2008)

Stanford Advisors


Publications

All Publications


  • Three-dimensional cryogels for biomedical applications. Journal of biomedical materials research. Part A Razavi, M., Qiao, Y., Thakor, A. S. 2019

    Abstract

    Cryogels are a subset of hydrogels synthesized under sub-zero temperatures: initially solvents undergo active freezing, which causes crystal formation, which is then followed by active melting to create interconnected supermacropores. Cryogels possess several attributes suited for their use as bioscaffolds, including physical resilience, bio-adaptability, and a macroporous architecture. Furthermore, their structure facilitates cellular migration, tissue-ingrowth, and diffusion of solutes, including nano- and micro-particle trafficking, into its supermacropores. Currently, subsets of cryogels made from both natural biopolymers such as gelatin, collagen, laminin, chitosan, silk fibroin, and agarose and/or synthetic biopolymers such as hydroxyethyl methacrylate, poly-vinyl alcohol, and poly(ethylene glycol) have been employed as 3D bioscaffolds. These cryogels have been used for different applications such as cartilage, bone, muscle, nerve, cardiovascular, and lung regeneration. Cryogels have also been used in wound healing, stem cell therapy and diabetes cellular therapy. In this review, we summarize the synthesis protocol and properties of cryogels, evaluation techniques as well as current in vitro and in vivo cryogel applications. A discussion of the potential benefit of cryogels for future research and their application are also presented. This article is protected by copyright. All rights reserved.

    View details for DOI 10.1002/jbm.a.36777

    View details for PubMedID 31408265

  • Three-dimensional graphene foam as a conductive scaffold for cardiac tissue engineering JOURNAL OF BIOMATERIALS APPLICATIONS Bahrami, S., Baheiraei, N., Mohseni, M., Razavi, M., Ghaderi, A., Azizi, B., Rabiee, N., Karimi, M. 2019; 34 (1): 74–85
  • Assessment of magnesium-based biomaterials: from bench to clinic BIOMATERIALS SCIENCE Razavi, M., Huang, Y. 2019; 7 (6): 2241–63

    View details for DOI 10.1039/c9bm00289h

    View details for Web of Science ID 000474065900002

  • Adipose tissue-derived mesenchymal stem cells rescue the function of islets transplanted in sub-therapeutic numbers via their angiogenic properties CELL AND TISSUE RESEARCH Ren, G., Rezaee, M., Razavi, M., Taysir, A., Wang, J., Thakor, A. S. 2019; 376 (3): 353–64
  • Three-dimensional graphene foam as a conductive scaffold for cardiac tissue engineering. Journal of biomaterials applications Bahrami, S., Baheiraei, N., Mohseni, M., Razavi, M., Ghaderi, A., Azizi, B., Rabiee, N., Karimi, M. 2019: 885328219839037

    Abstract

    Myocardial infarction is one of the major causes of mortality throughout the world. Cardiac scaffolds are tissue-engineered structures for the treatment of myocardial infarction and are employed for tissue support and cell delivery to the injured region. In this study, we fabricated nanostructured graphene foams as porous and biocompatible cardiac tissue-engineering scaffolds. Three-dimensional graphene foam and two-dimensional graphene were fabricated using chemical vapor deposition. We showed that the nickel etching had no effect on the structural appearance of the three-dimensional graphene foam. Toxicity of the prepared samples was evaluated on human umbilical vein endothelial cells at 48 h and 72 h and showed no toxic effects on the viability of the cells. Moreover, both samples supported the adhesion and growth of neonatal cardiomyocytes with three-dimensional graphene foam showing a more extensive effect on the expression of the cardiac genes involved in muscle contraction and relaxation (troponin-T) and gap junctions (Connexin 43). Hence, conductive three-dimensional graphene foam with its large surface area and specific surface properties could provide a promising platform for cardiac tissue engineering.

    View details for PubMedID 30961432

  • Adipose tissue-derived mesenchymal stem cells rescue the function of islets transplanted in sub-therapeutic numbers via their angiogenic properties. Cell and tissue research Ren, G., Rezaee, M., Razavi, M., Taysir, A., Wang, J., Thakor, A. S. 2019

    Abstract

    A significant proportion of islets are lost following transplantation due to hypoxia and inflammation. We hypothesize that adipose tissue-derived mesenchymal stem cells (AD-MSCs) can rescue a sub-therapeutic number of transplanted islets by helping them establish a new blood supply and reducing inflammation. Diabetic mice received syngeneic transplantation with 75 (minimal), 150 (sub-therapeutic), or 225 (therapeutic) islets, with or without 1*106 mouse AD-MSCs. Fasting blood glucose (FBG) values were measured over 6weeks with tissue samples collected for islet structure and morphology (H&E, insulin/glucagon staining). Histological and immunohistochemical analyses of islets were also performed at 2weeks in animals transplanted with a sub-therapeutic number of islets, with and without AD-MSCs, to determine new blood vessel formation, the presence of pro-angiogenic factors facilitating revascularization, and the degree of inflammation. AD-MSCs had no beneficial effect on FBG values when co-transplanted with a minimal or therapeutic number of islets. However, AD-MSCs significantly reduced FBG values and restored glycemic control in diabetic animals transplanted with a sub-therapeutic number of islets. Islets co-transplanted with AD-MSCs preserved their native morphology and organization and exhibited less aggregation when compared to islets transplanted alone. In the sub-therapeutic group, AD-MSCs significantly increased islet revascularization and the expression of angiogenic factors including hepatocyte growth factor (HGF) and angiopoietin-1 (Ang-1) while also reducing inflammation. AD-MSCs can rescue the function of islets when transplanted in a sub-therapeutic number, for at least 6weeks, via their ability to maintain islet architecture while concurrently facilitating islet revascularization and reducing inflammation.

    View details for PubMedID 30707291

  • A Magnesium-based Nanobiocomposite Processed by a Novel Technique Combining High Shear Solidification and Hot Extrusion. Recent patents on nanotechnology Razavi, M., Huang, Y. 2019; 13 (1): 38–48

    Abstract

    Most of the currently available Mg-based biomaterials corrode too fast in the physiological environment, causing many problems including hydrogen bubble release and premature mechanical failure. It is commonly recognized that high biodegradation rate is the major factor limiting their clinical applications.The present research aims to develop a new magnesium (Mg)-based biomaterial with a controlled biodegradation rate.A magnesium-hydroxyapatite (Mg-1.61Zn-0.18Mn-0.5Ca/1HA) nanocomposite was developed by a novel technique which combines high shear solidification and hot extrusion, followed by heat treatment. The microstructure and biodegradation rate of the nanocomposite in HBSS Hanks' Balanced Salt Solution were assessed. Biodegradation behaviour was studied using electrochemical corrosion and immersion test. Optical Microscopy (OM), Scanning Electron Microscopy (SEM) and Energy Dispersive Spectroscopy (EDS) were used to characterize the surface microstructure, biodegradation morphology and to analyse the biodegradation products. Few patents were also cited in the article.Under the optimized procedure of high shear solidification, extrusion and heat treatment at 400°C, the Mg-1.61Zn-0.18Mn-0.5Ca/1HA exhibited a satisfactory biodegradation rate of 0.12±0.04 mm/year.This technology shows a potential of breakthrough innovation in the manufacturing of Mg-based biomaterials with a decreased biodegradation rate.

    View details for PubMedID 30599113

  • Assessment of magnesium-based biomaterials: from bench to clinic. Biomaterials science Razavi, M., Huang, Y. 2019

    Abstract

    Despite the high potential of biodegradable magnesium (Mg) alloys as a new generation of biomaterials for orthopaedic and cardiovascular implantation, their high corrosion rate in body fluid limits their suitability for clinical applications. Extensive research has been performed to improve the corrosion resistance of Mg-based biomaterials. Researchers have also been working to develop new testing and assessment techniques to evaluate the corrosion performance and other in vitro and in vivo properties of their modified Mg alloys. The objective of this review is to present the principles and operation procedures of commonly used standard methods for assessment of Mg-based biomaterials from bench to clinic. The pros and cons of each of these methods are discussed, together with factors for consideration to choose the right methodology. This review also presents the current state and challenges in understanding the testing of Mg-based biomaterials.

    View details for PubMedID 31069348

  • Improvement of in vitro behavior of an Mg alloy using a nanostructured composite bioceramic coating. Journal of materials science. Materials in medicine Razavi, M., Fathi, M., Savabi, O., Tayebi, L., Vashaee, D. 2018; 29 (11): 159

    Abstract

    Magnesium (Mg) alloys as a new group of biodegradable metal implants are being extensively investigated as a promising selection for biomaterials applications due to their apt mechanical and biological performance. However, as a foremost drawback of Mg alloys, the high degradation in body fluid prevents its clinical applications. In this work, a bioceramic composite coating is developed composed of diopside, bredigite, and fluoridated hydroxyapatite on the AZ91 Mg alloy in order to moderate the degradation rate, while improving its bioactivity, cell compatibility, and mechanical integrity. Microstructural studies were performed using a transmission electron microscope (TEM), scanning electron microscope (SEM), X-ray diffraction (XRD) analysis, and energy dispersive spectroscopy (EDS). The degradation properties of samples were carried out under two steps, including electrochemical corrosion test and immersion test in simulated body fluid (SBF). Additionally, compression test was performed to evaluate the mechanical integrity of the specimens. L-929 fibroblast cells were cultured on the samples to determine the cell compatibility of the samples, including the cell viability and attachment. The degradation results suggest that the composite coating decreases the degradation and improves the bioactivity of AZ91 Mg alloy substrate. No considerable deterioration in the compression strength was observed for the coated samples compared to the uncoated sample after 4 weeks immersion. Cytotoxicity test indicated that the coatings improve the cell compatibility of AZ91 alloy for L-929 cells.

    View details for PubMedID 30350229

  • Improvement of in vitro behavior of an Mg alloy using a nanostructured composite bioceramic coating JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE Razavi, M., Fathi, M., Savabi, O., Tayebi, L., Vashaee, D. 2018; 29 (10)
  • Effect of cleaning methods on retentive values of saliva-contaminated implant-supported zirconia copings CLINICAL ORAL IMPLANTS RESEARCH Nejatidanesh, F., Savabi, O., Savabi, G., Razavi, M. 2018; 29 (5): 530–36

    Abstract

    The aim of this study was to evaluate the effect of different cleaning regimens on retentive strength of saliva-contaminated implant-supported zirconia copings.Seventy solid titanium abutments with 5.5 mm height (Straumann) were attached to the regular neck implant analogs (Straumann). The abutment-analog complex was mounted vertically in an autopolymerized T-shaped acrylic resin block. Seventy zirconia copings with an occlusal loop were made. The copings were contaminated with fresh human saliva for 1 min (except the control group). Afterward, the specimens were washed with water spray for 15 s and dried for 15 s. The copings were divided into seven groups according to cleaning methods (n = 10). Group 1: no contamination (control group); Group 2: water spray rinsing; Group 3: airborne particle abrasion; Group 4: immersion in 96% isopropanol; Group 5: applying Ivoclean (Ivoclar Vivadent); Group 6: applying 1% sodium hypochlorite; and Group 7: applying Monobond Plus (Ivoclar Vivadent). The copings were luted with a resin luting agent (RelyX Unicem; 3M ESPE). After 5,000 thermal cycles, the retentive values of the restorations were tested using universal testing machine. The dislodging forces were analyzed using one-way analysis of variance and the Tukey's HSD tests (α = 0.05).The copings, which were cleaned with Ivoclean and 96% isopropanol, showed the highest retentive values (204.79 ± 44.49 and 232.65 ± 71.36, respectively). There was a significant difference between the studied groups (F = 2.735; p = .02). Tukey's HSD showed that there was no significant difference between the different cleaning procedures and control group except water rinsing group (p = .14). The lowest retentive value was related to the saliva-contaminated group, which were only cleaned with water rinsing method.The retentive values of zirconia-based restorations were adversely affected by saliva contaminations. These restorations can be cleaned by Ivoclean, 96% isopropanol, airborne particle abrasion, 1% sodium hypochlorite, or applying Monobond Plus before luting procedures.

    View details for PubMedID 29656421

  • An oxygen plasma treated poly(dimethylsiloxane) bioscaffold coated with polydopamine for stem cell therapy JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE Razavi, M., Thakor, A. S. 2018; 29 (5): 54

    Abstract

    In this study, 3D macroporous bioscaffolds were developed from poly(dimethylsiloxane) (PDMS) which is inert, biocompatible, non-biodegradable, retrievable and easily manufactured at low cost. PDMS bioscaffolds were synthesized using a solvent casting and particulate leaching (SCPL) technique and exhibited a macroporous interconnected architecture with 86 ± 3% porosity and 300 ± 100 µm pore size. As PDMS intrinsically has a hydrophobic surface, mainly due to the existence of methyl groups, its surface was modified by oxygen plasma treatment which, in turn, enabled us to apply a novel polydopamine coating onto the surface of the bioscaffold. The addition of a polydopamine coating to bioscaffolds was confirmed using composition analysis. Characterization of oxygen plasma treated-PDMS bioscaffolds coated with polydopamine (polydopamine coated-PDMS bioscaffolds) showed the presence of hydroxyl and secondary amines on their surface which resulted in a significant decrease in water contact angle when compared to uncoated-PDMS bioscaffolds (35 ± 3%, P < 0.05). Seeding adipose tissue-derived mesenchymal stem cells (AD-MSCs) into polydopamine coated-PDMS bioscaffolds resulted in cells demonstrating a 70 ± 6% increase in viability and 40 ± 5% increase in proliferation when compared to AD-MSCs seeded into uncoated-PDMS bioscaffolds (P < 0.05). In summary, this two-step method of oxygen plasma treatment followed by polydopamine coating improves the biocompatibility of PDMS bioscaffolds and only requires the use of simple reagents and mild reaction conditions. Hence, our novel polydopamine coated-PDMS bioscaffolds can represent an efficient and low-cost bioscaffold platform to support MSC therapies.

    View details for PubMedID 29725867

  • A collagen based cryogel bioscaffold coated with nanostructured polydopamine as a platform for mesenchymal stem cell therapy. Journal of biomedical materials research. Part A Razavi, M., Hu, S., Thakor, A. S. 2018

    Abstract

    Cryo-hydrogels (cryogels) are polymer hydrogels formed at sub-zero temperatures. Bioscaffolds created from cryogels have interconnected macropores which allow for cell migration, tissue-ingrowth, unhindered diffusion of solutes and mass transport of therapeutics. In this study, we developed collagen based cryogel bioscaffolds and coated them with polydopamine using a simple two-step technique. Cryogel bioscaffolds were synthesized by collagen crosslinking at -20°C and exhibited a macroporous interconnected architecture with 75%±3% porosity. Two groups of pore sizes were observed: 300±50 m and 30±10 m in diameter. The addition of a polydopamine coating to cryogel bioscaffolds was confirmed using composition analysis. This resulted in a 41%±5% decrease in water uptake, 81%±10% decrease in swelling rate and 12%±3% decrease in their degree of dissolution (p<0.05), with a 48%±2% increase in stiffness and 57%±5% increase in compressive strength (p<0.05). Seeding adipose tissue-derived mesenchymal stem cells (AD-MSCs) into polydopamine coated-cryogel bioscaffolds resulted in cells demonstrating a 52%±4% increase in viability and 33%±3% increase in proliferation when compared to AD-MSCs seeded into uncoated-cryogel bioscaffolds (p<0.05). In summary, our novel polydopamine coated-cryogel bioscaffold represents an efficient and low-cost bioscaffold platform to support MSC therapies. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2018.

    View details for PubMedID 29637738

  • Investigation of the mechanical properties and degradability of a modified chitosan-based scaffold Materials Chemistry and Physics Heidari, F., Razavi, M., E.Bahrololoom, M., Tahriri, M., Tayebi, L. 2018; 204 : 187-194
  • Evaluation of the mechanical properties, in vitro biodegradability and cytocompatibility of natural chitosan/hydroxyapatite/nano-Fe3O4 composite CERAMICS INTERNATIONAL Heidari, F., Razavi, M., Bahrololoom, M. E., Yazdimamaghani, M., Tahriri, M., Kotturi, H., Tayebi, L. 2018; 44 (1): 275–81
  • Porous magnesium-based scaffolds for tissue engineering MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS Yazdimamaghani, M., Razavi, M., Vashaee, D., Moharamzadeh, K., Boccaccini, A. R., Tayebi, L. 2017; 71: 1253-1266

    Abstract

    Significant amount of research efforts have been dedicated to the development of scaffolds for tissue engineering. Although at present most of the studies are focused on non-load bearing scaffolds, many scaffolds have also been investigated for hard tissue repair. In particular, metallic scaffolds are being studied for hard tissue engineering due to their suitable mechanical properties. Several biocompatible metallic materials such as stainless steels, cobalt alloys, titanium alloys, tantalum, nitinol and magnesium alloys have been commonly employed as implants in orthopedic and dental treatments. They are often used to replace and regenerate the damaged bones or to provide structural support for healing bone defects. Among the common metallic biomaterials, magnesium (Mg) and a number of its alloys are effective because of their mechanical properties close to those of human bone, their natural ionic content that may have important functional roles in physiological systems, and their in vivo biodegradation characteristics in body fluids. Due to such collective properties, Mg based alloys can be employed as biocompatible, bioactive, and biodegradable scaffolds for load-bearing applications. Recently, porous Mg and Mg alloys have been specially suggested as metallic scaffolds for bone tissue engineering. With further optimization of the fabrication techniques, porous Mg is expected to make a promising hard substitute scaffold. The present review covers research conducted on the fabrication techniques, surface modifications, properties and biological characteristics of Mg alloys based scaffolds. Furthermore, the potential applications, challenges and future trends of such degradable metallic scaffolds are discussed in detail.

    View details for DOI 10.1016/j.msec.2016.11.027

    View details for Web of Science ID 000390967200142

    View details for PubMedID 27987682

  • Smart Biomaterials for Tissue Engineering of Cartilage SMART MATERIALS FOR TISSUE ENGINEERING: APPLICATIONS Fahmy, M. D., Shah, B., Razavi, M., Jazayeri, H., Fahimipour, F., White, J., Masri, R., Tayebi, L., Wang, Q. 2017; 25: 194–229
  • Metallic scaffolds Frontiers in Biomaterials: Biomaterials for Tissue Engineering Razavi, M. edited by Razavi, M. Bentham e Books. 2017
  • Naturally based and biologically derived nanobiomaterials NANOBIOMATERIALS SCIENCE, DEVELOPMENT AND EVALUATION Razavi, M., Zhu, K., Zhang, Y. S., Razavi, M., Thakor, A. 2017: 61–86
  • Lipid-based nanobiomaterials NANOBIOMATERIALS SCIENCE, DEVELOPMENT AND EVALUATION Nazemi, P., Razavi, M., Razavi, M., Thakor, A. 2017: 125–33
  • Particles/Fibers/Bulk NANOBIOMATERIALS SCIENCE, DEVELOPMENT AND EVALUATION Kiaie, N., Aavani, F., Razavi, M., Razavi, M., Thakor, A. 2017: 7–25
  • Safety, regulatory issues, long-term biotoxicity, and the processing environment NANOBIOMATERIALS SCIENCE, DEVELOPMENT AND EVALUATION Razavi, M., Khandan, A., Razavi, M., Thakor, A. 2017: 261–79
  • Nanobiomaterials Science, Development and Evaluation Introduction NANOBIOMATERIALS SCIENCE, DEVELOPMENT AND EVALUATION Razavi, M., Razavi, M., Thakor, A. 2017: 1–5
  • Microstructure, mechanical and electrochemical performance of a biodegradable Mg-2Zn-0.2Mn-0.5Ca/2HA nanocomposite 9th Biometals Symposium on biodegradable metals for biomedical applications, 2017, Italy. Huang, Y., Razavi, M. 2017
  • Development of electro-co-deposited Ni-Fe(Ti,W)C nanocomposite coatings Surface Engineering Karbasi, M., Khorsand, S., Sayyedan, F., Eshaghian, M., Razavi, M. 2017
  • The cross-disciplinary emergence of 3D printed bioceramic scaffolds in orthopedic bioengineering Ceramics International Jazayeri, H., Rodriguez-Romero, M., Razavi, M., Tahriri, M., Ganjawalla, K., Rasoulianboroujeni, M., Malekoshoaraie, M., Khoshroo, K., Tayebi, L. 2017
  • The impact of high shear treatment on the HA particle distribution and microstructure of Mg-HA nanocomposite castings 6th Decennial Inter Conf on Solidification Processing, 2017, UK. Huang, Y., Zhou, L., Razavi, M. 2017
  • Stem Cell Biology and Regenerative Medicine edited by Razavi, M. Bentham e Books. 2017; 5
  • A novel Raman active theranostic nanoparticle for detection of oxidative stress in tumors Canary Center All Staff Meeting, Canary Center at Stanford for Cancer Early Detection, 2017, Stanford University, USA Razavi, M., Thakor, A. 2017
  • A comparison between the properties of natural hydroxyapatite produced by cold isostatic pressing and spark plasma sintering techniques Journal of Australian Ceramic Society Heidari, F., Razavi, M., Askari Zamani, M., Tahriri, M., Tayebi, L. 2017
  • A chemically reactive raman probe for imaging oxidative stress in tumors Center for Cancer Nanotechnology Excellence for Translational Diagnostics (CCNE-TD), 2017, Stanford University, USA Razavi, M., Thakor, A. 2017
  • Biomaterials for Tissue Engineering edited by Razavi, M. Bentham e Books. 2017; 4
  • Liver and Kidney Tissue Engineering Frontiers in Biomaterials: Stem Cell Biology and Regenerative Medicine Khatami, F., Razavi, M., Zhang, Y. edited by Razavi, M. Bentham e Books. 2017
  • Nanobiomaterials Science, Development and Evaluation edited by Razavi, M., Thakor, A. Elsevier. 2017
  • Immune Aspects of Scaffold Design Frontiers in Biomaterials: Biomaterials for Tissue Engineering Mokhtari, N., Mokhtari, H., Razavi, M. edited by Razavi, M. Bentham e Books. 2017
  • Stem Cell-based modalities: from basic biology to integration and regeneration Frontiers in Biomaterials: Stem Cell Biology and Regenerative Medicine Xu, R., Shi, W., Nie, P., Chen, R., Li, N., Razavi, M., Niu, W., Alshihri, A. edited by Razavi, M. Bentham e Books. 2017
  • Gradient Fabrication Frontiers in Biomaterials: Biomaterials for Tissue Engineering Kiaie, N., Razavi, M. edited by Razavi, M. Bentham e Books. 2017
  • Hydrogels: Types, Structure, Properties, and Applications Frontiers in Biomaterials: Biomaterials for Tissue Engineering Khandan, A., Jazayeri, H., Fahmy, M., Razavi, M. edited by Razavi, M. Bentham e Books. 2017
  • Naturally-based and biologically derived nanobiomaterials Nanobiomaterials Science, Development and Evaluation Razavi, M., Zhu, K., Zhang, Y. edited by Razavi, M., Thakor, A. Elsevier. 2017
  • Investigation of mechanical properties of natural hydroxyapatite samples prepared by cold isostatic pressing method Journal of Alloys and Compounds Heidari, F., Razavi, M., Ghaedi, M., Forooghi, M., Tahriri, M., Tayebi, L. 2017; 693: 1150-1156
  • Smart Biomaterials for Tissue Engineering of Cartilage Smart Materials for Tissue Engineering: Applications Fahmy, M., Shah, B., Razavi, M., Jazayeri, H., Fahimpour, F., White, J., Masri, R., Tayebi, L. edited by Wang, Q. The Royal Society of Chemistry . 2017: 194–229
  • Preparation of natural chitosan from shrimp shell with different deacetylation degree Materials Research Innovations Heidari, F., Razavi, M., Bahrololoom, M., Tahriri, M., Rasoulianboroujeni, M., Koturi, H., Tayebi, L. 2017
  • In vitro analysis of Mg scaffolds coated with polymer/hydrogel/ceramic composite layers SURFACE & COATINGS TECHNOLOGY Yazdimamaghani, M., Razavi, M., Vashaee, D., Pothineni, V. R., Assefa, S., Kohler, G. A., Rajadas, J., Tayebi, L. 2016; 301: 126-132
  • The effect of pore structure on the mechanical properties of titanium scaffolds MATERIALS LETTERS Khodaei, M., Meratian, M., Savabi, O., Razavi, M. 2016; 171: 308-311
  • Bio-based nanostructured materials Nanobiomaterials: Nanostructured materials for biomedical applications Razavi, M. edited by Narayan, R. Elsevier. 2016
  • Human embryonic kidney cell behaviour on a new β-type titanium alloy by alamar blue assay Annual Conference and Expo on Biomaterials Razavi, M., Burugapalli, K., Zhou, L., Huang, Y. 2016

    View details for DOI 10.4172/2155-952X.C1.049

  • Introduction Nanobiomaterials Science, Development and Evaluation Razavi, M. Elsevier. 2016
  • Development of Mg/HA nanobiocomposite implants using high shear solidification, extrusion and heat treatment technique 2016, Brunel University London, UK Razavi, M., Huang, Y. 2016
  • A current overview of materials and strategies for potential use in maxillofacial tissue regeneration Materials Science and Engineering C Jazayeri, H., Tahriri, M., Razavi, M., Khoshroo, K., Fahimipour, F., Dashtimoghadam, E., Almeida, L., Tayebi, L. 2016
  • Dental applications of natural-origin polymers in hard and soft tissue engineering JOURNAL OF PROSTHODONTICS Jazayeri, H., Razavi, M., Fahmy, M., Stein, B., Nowman, A., Masri, R., Tayebi, L. 2016

    View details for DOI 10.1111/jopr.12465

  • Three-dimensional bioprinting materials with potential application in preprosthetic surgery JOURNAL OF PROSTHODONTICS Fahmy, M., Jazayeri, H., Razavi, M., Masri, R., Tayebi, L. 2016

    View details for DOI 10.1111/jopr.12431

  • Mechanical properties of natural chitosan/hydroxyapatite/magnetite nanocomposites for tissue engineering applications MATERIALS SCIENCE AND ENGINEERING C Heidari, F., Razavi, M., E.Bahrololoom, M., Bazargan-Lari, R., Vashaee, D., Kotturi, H., Tayebi, L. 2016; 65: 338–344
  • Biomedical Applications of Intelligent Nanostructured Materials Intelligent Nanomaterials Fahmy, M., Jazayeri, H., Razavi, M., Omidi, M., Zahedinik, M., Pitcher, S., Salahinejad, E., Tayebi, L. edited by Thompson, S., Tiwari, A. Wiley-Scrivener. 2016
  • Medical β-type Ti-35.5Nb-5.7Ta titanium alloy/cell interaction BCAST Advanced Metal Casting Centre (AMCC), 2016, Brunel University London, UK Razavi, M., Burugapalli, K., Huang, Y. 2016
  • Nanobiomaterials in periodontal tissue engineering Nanobiomaterials in Hard Tissue Engineering Razavi, M., Salahinejad, E., Fahmy, M., Nowman, A., Jazayeri, H., Shah, P., Vashaee, D., Tayebi, P., Tayebi, L. edited by Grumezescu, A. Elsevier. 2016: 323–351
  • Surface modification of Ti6Al4V implants by heat, H2O2 and alkali treatments SURFACE ENGINEERING Khodaei, M., Meratian, M., Shaltooki, M., Hashemibeni, B., Savabi, O., Razavi, M. 2016
  • In vitro cytocompatibility study of a medical β-type Ti-35.5Nb-5.7Ta titanium alloy JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING Burugapalli, K., Razavi, M., Zhou, L., Huang, Y. 2016; 6: 141-488

    View details for DOI 10.1166/jbt.2016.1424

  • Regenerative influence of nanostructured bredigite (Ca7MgSi4O16)/anodic spark coating on biodegradable AZ91 magnesium alloy implants for bone healing MATERIALS LETTERS Razavi, M., Fathi, M., Savabi, O., Vashaee, D., Tayebi, L. 2015; 155: 97-101
  • Surface modification of stainless steel implants using nanostructured forsterite (Mg2SiO4) coating for biomaterial applications SURFACE & COATINGS TECHNOLOGY Kheirkhah, M., Fathi, M., Salimijazi, H. R., Razavi, M. 2015; 276: 580-586
  • In vivo biocompatibility of Mg implants surface modified by nanostructured merwinite/PEO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE Razavi, M., Fathi, M., Savabi, O., Vashaee, D., Tayebi, L. 2015; 26 (5)

    Abstract

    Magnesium (Mg) alloys have been suggested as biodegradable bone implant materials due to their good intrinsic biocompatibility and great mechanical properties. Although magnesium has attractive properties as an orthopedic implant material, its quick degradation and low bioactivity may lead to the loss of mechanical integrity of the implant during the bone healing process. In this paper, we endeavor to surmount the abovementioned defects using the surface coating technique. We have recently coated AZ91 magnesium implants with merwinite (Ca3MgSi2O8) through the coupling of plasma electrolytic oxidation (PEO) and electrophoretic deposition method. In this work, we are specifically focused on the in vivo examinations of the coated implants in comparison with the uncoated one. For the in vivo experiment, the rod samples, including the uncoated and merwinite/PEO coated implants, were imbedded into the greater trochanter of rabbits. The results of the in vivo animal test indicated an improvement in biodegradability including slower implant weight loss, reduction in Mg ion released from the coated implants in the blood plasma, lesser release of hydrogen bubbles and an improvement in biocompatibility including an increase in the amount of bone formation and ultimately a mild bone inflammation after the surgery according to the histological images. In summary, proper surface treatment of magnesium implants such as silicate bioactive ceramics may improve their biocompatibility under physiological conditions to making them suitable and applicable for future clinical applications.

    View details for DOI 10.1007/s10856-015-5514-3

    View details for Web of Science ID 000354825500009

    View details for PubMedID 25893390

  • In vivo study of nanostructured akermanite/PEO coating on biodegradable magnesium alloy for biomedical applications JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A Razavi, M., Fathi, M., Savabi, O., Vashaee, D., Tayebi, L. 2015; 103 (5): 1798-1808

    Abstract

    The major issue for biodegradable magnesium alloys is the fast degradation and release of hydrogen gas. In this article, we aim to overcome these disadvantages by using a surface modified magnesium implant. We have recently coated AZ91 magnesium implants by akermanite (Ca2 MgSi2 O7 ) through the combined electrophoretic deposition (EPD) and plasma electrolytic oxidation (PEO) methods. In this work, we performed the in vitro and in vivo examinations of these coated implants using L-929 cell line and rabbit animal model. The in vitro study confirmed the higher cytocompatibility of the coated implants compare to the uncoated ones. For the in vivo experiment, the rod samples were implanted into the greater trochanter of rabbits and monitored for two months. The results indicated a noticeable biocompatibility improvement of the coated implants which includes slower implant weight loss, reduction in Mg ion released from the coated samples in the blood plasma, lower release of hydrogen bubbles, increase in the amount of bone formation and ultimately lower bone inflammation after the surgery according to the histological images. Our data exemplifies that the proper surface treatment of the magnesium implants can improve their biocompatibility under physiological conditions to make them applicable in clinical uses. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1798-1808, 2015.

    View details for DOI 10.1002/jbm.a.35324

    View details for Web of Science ID 000351843600021

    View details for PubMedID 25203515

  • In Vitro Analysis of Electrophoretic Deposited Fluoridated Hydroxyapatite Coating on Micro-arc Oxidized AZ91 Magnesium Alloy for Biomaterials Applications METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE Razavi, M., Fathi, M., Savabi, O., Vashaee, D., Tayebi, L. 2015; 46A (3): 1394-1404
  • In vivo assessments of bioabsorbable AZ91 magnesium implants coated with nanostructured fluoridated hydroxyapatite by MAO/EPD technique for biomedical applications MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS Razavi, M., Fathi, M., Savabi, O., Vashaee, D., Tayebi, L. 2015; 48: 21-27

    Abstract

    Although magnesium (Mg) is a unique biodegradable metal which possesses mechanical property similar to that of the natural bone and can be an attractive material to be used as orthopedic implants, its quick corrosion rate restricts its actual clinical applications. To control its rapid degradation, we have modified the surface of magnesium implant using fluoridated hydroxyapatite (FHA: Ca10(PO4)6OH2-xFx) through the combined micro-arc oxidation (MAO) and electrophoretic deposition (EPD) techniques, which was presented in our previous paper. In this article, the biocompatibility examinations were conducted on the coated AZ91 magnesium alloy by implanting it into the greater trochanter area of rabbits. The results of the in vivo animal test revealed a significant enhancement in the biocompatibility of FHA/MAO coated implant compared to the uncoated one. By applying the FHA/MAO coating on the AZ91 implant, the amount of weight loss and magnesium ion release in blood plasma decreased. According to the histological results, the formation of the new bone increased and the inflammation decreased around the implant. In addition, the implantation of the uncoated AZ91 alloy accompanied by the release of hydrogen gas around the implant; this release was suppressed by applying the coated implant. Our study exemplifies that the surface coating of magnesium implant using a bioactive ceramic such as fluoridated hydroxyapatite may improve the biocompatibility of the implant to make it suitable as a commercialized biomedical product.

    View details for DOI 10.1016/j.msec.2014.11.020

    View details for Web of Science ID 000348749200004

    View details for PubMedID 25579892

  • Significant degradability enhancement in multilayer coating of polycaprolactone-bioactive glass/gelatin-bioactive glass on magnesium scaffold for tissue engineering applications APPLIED SURFACE SCIENCE Razavi, M., Yazdimamaghani, M., Vashaee, D., Pothineni, V., Rajadas, J., Tayebi, L. 2015; 338: 137-145
  • Biomineralization and biocompatibility studies of bone conductive scaffolds containing poly(3,4-ethylenedioxythiophene):poly(4-styrene sulfonate) (PEDOT:PSS) JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE Razavi, M., Yazdimamaghani, M., Mozafari, M., Vashaee, D., Kotturi, H., Tayebi, L. 2015; 26: 274-284
  • Surface modification of biodegradable porous Mg bone scaffold using polycaprolactone/bioactive glass composite MATERIALS SCIENCE AND ENGINEERING C Razavi, M., Yazdimamaghani, M., Vashaee, D., Tayebi, L. 2015; 49: 436-444
  • Green Chemical and Biological Synthesis of Nanoparticles and their Biomedical Applications Green Processes for Nanotechnology: From Inorganic to Bioinspired Nanomaterials Razavi, M., Salahinejad, E., Fahmy, M., Yazdimamaghani, M., Vashaee, D., Tayebi, L. edited by Basiuk, V., Basiuk, E. Springer International Publishing Switzerland. 2015: 207–235
  • Improvement of Biodegradability, Bioactivity, Mechanical Integrity and Cytocompatibility Behavior of Biodegradable Mg Based Orthopedic Implants Using Nanostructured Bredigite (Ca7MgSi4O16) Bioceramic Coated via ASD/EPD Technique ANNALS OF BIOMEDICAL ENGINEERING Razavi, M., Fathi, M., Savabi, O., Vashaee, D., Tayebi, L. 2014; 42 (12): 2537-2550

    Abstract

    This research explored the influence of surface modification of AZ91 Mg alloy on the biodegradation, bioactivity, mechanical integrity and cytocompatibility of the alloy. For this purpose, a nanostructured bredigite (Ca7MgSi4O16) ceramic coating was prepared on biodegradable AZ91 Mg alloy through anodic spark deposition and electrophoretic deposition method. The phase composition and surface morphology of the coated alloy were characterized by X-ray diffraction, scanning electron microscope and transmission electron microscope. The properties of samples were investigated by electrochemical measurements, immersion test, compression examination and cell culturing. The results showed that the degradation resistance, bioactivity, mechanical integrity and cytocompatibility of biodegradable Mg alloy were improved by the anodic spark deposition and electrophorretic deposition of the nanostructured bredigite coating. Therefore, the nanostructured bredigite ceramic coating is identified as a good coating for AZ91 Mg alloy for the purpose of making biodegradable metallic orthopedic implants.

    View details for DOI 10.1007/s10439-014-1084-7

    View details for Web of Science ID 000345394000014

    View details for PubMedID 25118669

  • In vivo study of nanostructured diopside (CaMgSi2O6) coating on magnesium alloy as biodegradable orthopedic implants APPLIED SURFACE SCIENCE Razavi, M., Fathi, M., Savabi, O., Razavi, S. M., Heidari, F., Manshaei, M., Vashaee, D., Tayebi, L. 2014; 313: 60-66
  • In vitro study of nanostructured diopside coating on Mg alloy orthopedic implants MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS Razavi, M., Fathi, M., Savabi, O., Vashaee, D., Tayebi, L. 2014; 41: 168-177

    Abstract

    The high corrosion rate of Mg alloys has hindered their application in various areas, particularly for orthopedic applications. In order to decrease the corrosion rate and to improve the bioactivity, mechanical stability and cytocompatibility of the Mg alloy, nanostructured diopside (CaMgSi2O6) has been coated on AZ91 Mg alloy using a combined micro arc oxidation (MAO) and electrophoretic deposition (EPD) method. The crystalline structure, the morphology and the composition of the samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Electrochemical corrosion test, immersion test, and compression test were used to evaluate the corrosion resistance, the in vitro bioactivity and the mechanical stability of the samples, respectively. The cytocompatibility of the samples was tested by the cell viability and the cell attachment of L-929 cells. The results confirmed that the diopside coating not only slows down the corrosion rate, but also enhances the in vitro bioactivity, mechanical stability and cytocompatibility of AZ91 Mg alloy. Therefore, Mg alloy coated with nanostructured diopside offers a promising approach for biodegradable bone implants.

    View details for DOI 10.1016/j.msec.2014.04.039

    View details for Web of Science ID 000338606700021

    View details for PubMedID 24907750

  • Nanostructured merwinite bioceramic coating on Mg alloy deposited by electrophoretic deposition CERAMICS INTERNATIONAL Razavi, M., Fathi, M., Savabi, O., Beni, B. H., Vashaee, D., Tayebi, L. 2014; 40 (7): 9473-9484
  • Biodegradable magnesium alloy coated by fluoridated hydroxyapatite using MAO/EPD technique SURFACE ENGINEERING Razavi, M., Fathi, M., Savabi, O., Vashaee, D., Tayebi, L. 2014; 30 (8): 545-551
  • Micro-arc oxidation and electrophoretic deposition of nano-grain merwinite (Ca3MgSi2O8) surface coating on magnesium alloy as biodegradable metallic implant SURFACE AND INTERFACE ANALYSIS Razavi, M., Fathi, M., Savabi, O., Vashaee, D., Tayebi, L. 2014; 46 (6): 387-392

    View details for DOI 10.1002/sia.5465

    View details for Web of Science ID 000335451600004

  • Surface microstructure and in vitro analysis of nanostructured akermanite (Ca2MgSi2O7) coating on biodegradable magnesium alloy for biomedical applications COLLOIDS AND SURFACES B-BIOINTERFACES Razavi, M., Fathi, M., Savabi, O., Beni, B. H., Vashaee, D., Tayebi, L. 2014; 117: 432-440

    Abstract

    Magnesium (Mg) alloys, owing to their biodegradability and good mechanical properties, have potential applications as biodegradable orthopedic implants. However, several poor properties including low corrosion resistance, mechanical stability and cytocompatibility have prevented their clinical application, as these properties may result in the sudden failure of the implants during the bone healing. In this research, nanostructured akermanite (Ca2MgSi2O7) powder was coated on the AZ91 Mg alloy through electrophoretic deposition (EPD) assisted micro arc oxidation (MAO) method to modify the properties of the alloy. The surface microstructure of coating, corrosion resistance, mechanical stability and cytocompatibility of the samples were characterized with different techniques including X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), electrochemical corrosion test, immersion test, compression test and cell culture test. The results showed that the nanostructured akermanite coating can improve the corrosion resistance, mechanical stability and cytocompatibility of the biodegradable Mg alloy making it a promising material to be used as biodegradable bone implants for orthopedic applications.

    View details for DOI 10.1016/j.colsurfb.2013.12.011

    View details for Web of Science ID 000336018700057

    View details for PubMedID 24721316

  • Controlling the degradation rate of bioactive magnesium implants by electrophoretic deposition of akermanite coating CERAMICS INTERNATIONAL Razavi, M., Fath, M., Savabi, O., Razavi, S. M., Beni, B. H., Vashaee, D., Tayebi, L. 2014; 40 (3): 3865-3872
  • Biodegradation, bioactivity and in vivo biocompatibility analysis of plasma electrolytic oxidized (PEO) biodegradable Mg implants PHYSICAL SCIENCE INTERNATIONAL JOURNAL Razavi, M., Fathi, M., Savabi, O., Vashaee, D., Tayebi, L. 2014; 4: 708-722
  • Development and degradation behavior of magnesium scaffolds coated with polycaprolactone for bone tissue engineering MATERIALS LETTERS Razavi, M., Yazdimamaghani, M., Vashaee, D., Tayebi, L. 2014; 132: 106-110
  • Coating of biodegradable magnesium alloy bone implants using nanostructured diopside (CaMgSi2O6) APPLIED SURFACE SCIENCE Razavi, M., Fathi, M., Savabi, O., Beni, B. H., Razavi, S. M., Vashaee, D., Tayebi, L. 2014; 288: 130-137
  • Microstructural and mechanical study of PCL coated Mg scaffolds SURFACE ENGINEERING Razavi, M., Yazdimamaghani, M., Vashaee, D., Tayebi, L. 2014; 30: 920-926
  • In vitro evaluations of anodic spark deposited AZ91 alloy as biodegradable metallic orthopedic implant ANNUAL RESEARCH & REVIEW IN BIOLOGY Razavi, M., Fathi, M., Savabi, O., Vashaee, D., Tayebi, L. 2014; 4: 3716-3733
  • Comparative study on the biodegradation and biocompatibility of silicate bioceramic coatings on biodegradable magnesium alloy as biodegradable biomaterial APS March Meeting Razavi, M., Fathi, M., Savabi, O., Razavi, S., Hashemibeni, B., Yazdimamaghani, M., Vashaee, D., Tayebi, L. 2014
  • Surface modification of magnesium alloy implants by nanostructured bredigite coating MATERIALS LETTERS Razavi, M., Fathi, M., Savabi, O., Razavi, S. M., Beni, B. H., Vashaee, D., Tayebi, L. 2013; 113: 174-178
  • DEVELOPMENT AND CHARACTERIZATION OF SiC-Al2O3-Al CERAMIC MATRIX NANOCOMPOSITE POWDER NANO Karbasi, M., Razavi, M., Azadi, M., Tayebi, L. 2013; 8 (6)
  • Preparation of Al-SiC-Al2O3 metal matrix composite powder by mechanochemical reaction between Al, SiO2 and C MICRO & NANO LETTERS Karbasi, M., Razavi, M., Taheri, M., Vashaee, D., Tayebi, L. 2013; 8 (9): 519-522
  • A Review of Degradation Properties of Mg Based Biodegradable Implants RESEARCH AND REVIEWS IN MATERIALS SCIENCE AND CHEMISTRY Razavi, M., Fathi, M., Savabi, O., Boroni, M. 2012; 1: 15-58
  • Biodegradable magnesium-fluorapatite metal matrix nanocomposite with improved corrosion resistance for biomedical applications New and Advanced Materials International Congress (NAMIC 2012) Razavi, M., Fathi, M., Meratian, M. 2012
  • Novel magnesium-nano fluorapatite metal matrix nanocomposite with improved biodegradation behavior JOURNAL OF BIOMEDICAL NANOTECHNOLOGY Fathi, M., Meratian, M., Razavi, M. 2011; 7: 1-5
  • Fabrication and characterization of magnesium-fluorapatite nanocomposite for biomedical applications MATERIALS CHARACTERIZATION Razavi, M., Fathi, M. H., Meratian, M. 2010; 61 (12): 1363-1370
  • Bio-corrosion behavior of magnesium-fluorapatite nanocomposite for biomedical applications MATERIALS LETTERS Razavi, M., Fathi, M. H., Meratian, M. 2010; 64 (22): 2487-2490
  • Microstructure, mechanical properties and bio-corrosion evaluation of biodegradable AZ91-FA nanocomposites for biomedical applications MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING Razavi, M., Fathi, M. H., Meratian, M. 2010; 527 (26): 6938-6944
  • Effect of fluorapatite nanoparticles as reinforcement on the biodegradation behavior of magnesium-based nanocomposite IEEE Razavi, M., Fathi, M., Meratian, M. 2010
  • Novel magnesium-nanofluorapatitemetal matrix nanocomposite with improvedbiodegradation behavior 4th International Conference on Advanced Computational Engineering and Experimenting (ACE-X 2010) Fathi, M., Meratian, M., Razavi, M. 2010
  • Fabrication and evaluation of corrosion behavior of AZ91-FA biodegradable nanocomposites for biomedical applications 8th Student Conferenceon Nanotechnology Razavi, M., Fathi, M., Meratian, M. 2010
  • Effect of fluorapatite nano particles as reinforcement on the biodegradation behavior of magnesium-based nanocomposite 17th Iranian Conference of Biomedical Engineering (ICBME) Razavi, M., Fathi, M., Meratian, M. 2009