Current Research and Scholarly Interests
Several neuronal diseases such as ischemic and hemorrhagic stroke and vascular dementia are associated with cerebral vascular injuries or pathologies. Cerebral vascular injuries cause blood brain barrier (BBB) disruption/dysfunction and BBB dysfunction is significantly associated with neurological diseases. Therefore, an understanding of the molecular mechanisms regulating BBB permeability and disruption is required for establishing efficacious therapeutic strategies.
There is currently a paucity of data available regarding the molecular mechanism of BBB dysfunction. microRNAs are small non-coding RNAs that regulate gene expression by targeting mRNAs. microRNAs have been implicated in the development and progression of various diseases, such as vascular disease. However the role of microRNAs on BBB breakdown or permeability remains unclear. We aim to determine the role of candidate microRNAs in BBB breakdown and consequently establish novel prevention and therapeutic interventions.