Clinical Focus

  • Gastroenterology

Academic Appointments

Professional Education

  • Board Certification: Gastroenterology, American Board of Internal Medicine (2013)
  • Fellowship:Stanford University School of Medicine (2011) CA
  • Board Certification: Internal Medicine, American Board of Internal Medicine (2009)
  • Residency:Stanford University School of Medicine (2008) CA
  • Internship:Stanford University School of Medicine (2007) CA
  • Medical Education:Mount Sinai School of Medicine (2006) NY


All Publications

  • A highly focused antigen receptor repertoire characterizes gamma delta T cells that are poised to make IL-17 rapidly in naive animals FRONTIERS IN IMMUNOLOGY Wei, Y., Han, A., Glanville, J., Fang, F., Zunige, L. A., Lee, J. S., Cue, D. J., Chien, Y. 2015; 6: 1-6
  • Linking T-cell receptor sequence to functional phenotype at the single-cell level NATURE BIOTECHNOLOGY Han, A., Glanville, J., Hansmann, L., Davis, M. M. 2014; 32 (7): 684-?

    View details for DOI 10.1038/nbt.2938

    View details for Web of Science ID 000338705900035

  • Linking T-cell receptor sequence to functional phenotype at the single-cell level. Nature biotechnology Han, A., Glanville, J., Hansmann, L., Davis, M. M. 2014; 32 (7): 684-692


    Although each T lymphocyte expresses a T-cell receptor (TCR) that recognizes cognate antigen and controls T-cell activation, different T cells bearing the same TCR can be functionally distinct. Each TCR is a heterodimer, and both ?- and ?-chains contribute to determining TCR antigen specificity. Here we present a methodology enabling integration of information about TCR specificity with information about T cell function. This method involves sequencing of TCR? and TCR? genes, and amplifying functional genes characteristic of different T cell subsets, in single T cells. Because this approach retains information about individual TCR?-TCR? pairs, TCRs of interest can be expressed and used in functional studies, for antigen discovery, or in therapeutic applications. We apply this approach to study the clonal ancestry and differentiation of T lymphocytes infiltrating a human colorectal carcinoma.

    View details for DOI 10.1038/nbt.2938

    View details for PubMedID 24952902

  • Dietary gluten triggers concomitant activation of CD4(+) and CD8(+) alpha beta T cells and gamma delta T cells in celiac disease PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Han, A., Newell, E. W., Glanville, J., Fernandez-Becker, N., Khosla, C., Chien, Y., Davis, M. M. 2013; 110 (32): 13073-13078
  • Virus-Specific CD4(+) Memory-Phenotype T Cells Are Abundant in Unexposed Adults IMMUNITY Su, L. F., Kidd, B. A., Han, A., Kotzin, J. J., Davis, M. M. 2013; 38 (2): 373-383


    Although Tácell memory is generally thought to require direct antigen exposure, we found an abundance of memory-phenotype cells (20%-90%, averaging over 50%) of CD4(+) Tácells specific to viral antigens in adults who had never been infected. These cells express the appropriate memory markers and genes, rapidly produce cytokines, and have clonally expanded. In contrast, the same Tácell receptor (TCR) specificities in newborns are almost entirely na´ve, which might explain the vulnerability of young children to infections. One mechanism foráthis phenomenon is TCR cross-reactivity to environmental antigens, and in support of this, we found extensive cross-recognition by HIV-1 and influenza-reactive T lymphocytes to other microbial peptides and expansion of one of these after influenza vaccination. Thus, the presence of these memory-phenotype Tácells has significant implications for immunity to novel pathogens, child and adult health, and theáinfluence of pathogen-rich versus hygienic environments.

    View details for DOI 10.1016/j.immuni.2012.10.021

    View details for Web of Science ID 000330940800018

    View details for PubMedID 23395677

  • The promised land of human immunology. Cold Spring Harbor symposia on quantitative biology Su, L. F., Han, A., McGuire, H. M., Furman, D., Newell, E. W., Davis, M. M. 2013; 78: 203-213


    Advances in technology and data analysis have made it possible to take a new look at human immunology. These advances run the gamut from systems biology approaches, which are likely in the vanguard of how we can start "to put the pieces together" of immune function, to a deeper understanding of specific diseases and vaccines and the immune repertoire. In our own experience, we have also found that asking simple questions about human immunity has often given us very surprising answers, causing a rethink of established dogma. Thus, we have developed a new perspective on the nature of the ?? TCR repertoire and also the likely role of T-cell repertoire (TCR) cross-reactivity in generating T memory independent of specific antigen interactions. These findings show that human immunology is not just a necessary step for "translating" basic immunology to treat diseases or develop better vaccines, but is also an important complement to the inbred mouse model.

    View details for DOI 10.1101/sqb.2013.78.022905

    View details for PubMedID 24638855

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