Bio

Bio


Dr. Tan is double board certified in Endocrinology and Internal Medicine. She practices general endocrinology, but her main clinical interests are outpatient and inpatient diabetes management. Her research interests include diabetes and post bariatric hypoglycemia. Dr. Tan is actively involved in resident and fellow education, and she has served as the Medical Student Clerkship Director, Residency Rotation Director, and Associate Program Director for the Endocrinology Fellowship Training Program. She is the chief of the Stanford Endocrine Clinic.

Clinical Focus


  • Endocrinology
  • Diabetes Mellitus
  • Diabetes and Metabolism

Academic Appointments


Administrative Appointments


  • Member, Stanford Diabetes Research Center (2017 - Present)
  • Associate Program Director, Endocrinology Fellowship Training Program, Stanford University School of Medicine (2017 - 2019)
  • Clinic Chief, Endocrine Clinic, Stanford Healthcare (2016 - Present)
  • Endocrinology Clerkship Director, Stanford University School of Medicine (2015 - 2017)
  • Resident Rotation Director, Stanford University School of Medicine (2014 - 2017)
  • Member, Stanford Healthcare Diabetes Task Force (2012 - Present)

Honors & Awards


  • Honors Certificate in Medical Education, Stanford University School of Medicine (2016)
  • Physician Educator, Stanford Japan Program (Tokushima, Japan) (2016)
  • Focus on Fellows Award, American Diabetes Association (2014)
  • Physician Educator, Stanford Japan Program (Okinawa, Japan) (2013)
  • Northern California Regional Poster Finalist, American College of Physicians (2012)
  • 1st Place Stanford 2020 QI Challenge, Stanford Hospital and Clinics (2010)
  • Phi Beta Kappa, University of California, Berkeley (2004)
  • Regents and Chancellor's Scholar, University of California, Berkeley (2001)

Boards, Advisory Committees, Professional Organizations


  • Physician Advisor, Stanford AIM Project for Educational Excellence (2014 - 2015)
  • Member, Endocrine Society (2012 - Present)
  • Member, American Diabetes Association (2012 - Present)
  • Member, American Association of Clinical Endocrinologists (2012 - Present)
  • Class Representative, Stanford Internal Medicine Committee for Residency Review (2011 - 2012)
  • House Staff Representative, Stanford University Medical Center Task Force for ACGME Site Visit (2011 - 2012)
  • House Staff Representative, Stanford University Medical Center Graduate Medical Education Committee (2011 - 2012)

Professional Education


  • Board Certification: Endocrinology, Diabetes and Metabolism, American Board of Internal Medicine (2014)
  • Board Certification, Endocrinology, Diabetes, and Metabolism, American Board of Internal Medicine (2014)
  • Fellowship:Stanford University Medical CenterCA
  • Board Certification: Internal Medicine, American Board of Internal Medicine (2012)
  • Residency:Stanford University Hospital -Clinical Excellence Research Center (2012) CA
  • Medical Education:Boston University School of Medicine (2009) MA
  • BA, University of California, Berkeley, Molecular and Cell Biology (Magna Cum Laude) (2005)

Community and International Work


  • UC Berkeley Student Learning Center

    Ongoing Project

    Yes

    Opportunities for Student Involvement

    No

  • UC Berkeley Regents and Chancellors Scholarship Association

    Ongoing Project

    Yes

    Opportunities for Student Involvement

    No

  • Pacific Free Clinic

    Ongoing Project

    No

    Opportunities for Student Involvement

    No

  • Tzu Chi Compassion Relief Medical Team

    Ongoing Project

    No

    Opportunities for Student Involvement

    Yes

  • Stanford University School of Medicine SIMS Program

    Location

    Bay Area

    Ongoing Project

    Yes

    Opportunities for Student Involvement

    No

Research & Scholarship

Current Research and Scholarly Interests


Type 2 diabetes, obesity, insulin resistance

Clinical Trials


  • A Multiple Ascending Dose Study to Evaluate Safety and Tolerability of BFKB8488A in Participants With Type 2 Diabetes Mellitus and Participants With Non-Alcoholic Fatty Liver Disease Recruiting

    This is a Phase Ib, randomized, blinded, placebo-controlled, multiple ascending−dose study of the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) effects of BFKB8488A in participants with Type 2 diabetes mellitus (T2DM) and participants with non-alcoholic fatty liver disease(NAFLD). A maximum of approximately 160 participants will be enrolled across multiple sites in the United States. Participants will be randomly assigned to receive study drug (active BFKB8488A or placebo). The study will consist of a screening period (up to 8 weeks), a 12-week treatment period, and a 6-week follow-up period. Participants may come to clinic for an optional pre-screening visit.

    View full details

  • Effect of Albiglutide, When Added to Standard Blood Glucose Lowering Therapies, on Major Cardiovascular Events in Subjects With Type 2 Diabetes Mellitus Not Recruiting

    Albiglutide is an analogue of glucagon-like peptide-1 (GLP-1), used to treat type 2 diabetes This study will test whether albiglutide affects the occurrence of major cardiovascular events such as heart attacks or strokes and other important medical outcomes in persons with type 2 diabetes, when used alone or added to other diabetes treatments.

    Stanford is currently not accepting patients for this trial. For more information, please contact SPECTRUM, (650) 721 - 1300.

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  • Efficacy, Tolerability and Pharmacokinetics of Subcutaneous Exendin (9-39) in Patients With Post Bariatric Hypoglycemia Not Recruiting

    This study is designed to evaluate the efficacy, safety and pharmacokinetics of subcutaneous exendin (9-39) in subjects with post-bariatric hypoglycemia. Development of this subcutaneous formulation of exendin (9-39) would represent a targeted therapeutic approach for this rare disease with unmet clinical need.

    Stanford is currently not accepting patients for this trial. For more information, please contact Cindy Lamendola, RN, MSN, NP, 650-723-3141.

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  • Safety and Efficacy of EndoBarrier in Subjects With Type 2 Diabetes Who Are Obese Not Recruiting

    To determine if the EndoBarrier safely and effectively improves glycemic control in obese subjects with type 2 diabetes

    Stanford is currently not accepting patients for this trial. For more information, please contact Elizabeth Colbert, 650-723-3186.

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  • Safety and Efficacy of Exendin 9-39 in Patients With Postbariatric Hypoglycemia Not Recruiting

    This clinical study will evaluate whether taking an investigational drug called exendin 9-39 is safe, well-tolerated, and helps to prevent low blood sugar in people who have had bariatric surgery and later develop a rare condition called postbariatric hypoglycemia (PBH).

    Stanford is currently not accepting patients for this trial. For more information, please contact Aileen Muno, (650) 725-9890.

    View full details

Projects


  • Improving Quality in Resident Continuity Clinics through Core Measure Education and Assessment, Stanford University School of Medicine

    Location

    Stanford, CA

  • Improving Patient Centered Care Through the Use of Whiteboards, Stanford Hospital and Clinics

    Location

    Stanford, CA

    Collaborators

    • Lisa Shieh, Clinical Professor, Medicine, Medicine
  • Protocol for Post Operative Endocrine Management Following Pituitary Surgery, Stanford Hospital and Clinics

    Location

    Stanford, CA

    Collaborators

  • Seminal Articles in Endocrinology - A Formalized Curriculum, Stanford University School of Medicine

    Location

    Stanford, CA

  • Stanford University School of Medicine Lane Library Endocrinology Portal, Stanford University

    Location

    94305

    Collaborators

    • Julie Chen, Clinical Assistant Professor, Stanford University School of Medicine

Teaching

Graduate and Fellowship Programs


  • Endocrinology (Fellowship Program)

Publications

All Publications


  • A longitudinal big data approach for precision health. Nature medicine Schüssler-Fiorenza Rose, S. M., Contrepois, K., Moneghetti, K. J., Zhou, W., Mishra, T., Mataraso, S., Dagan-Rosenfeld, O., Ganz, A. B., Dunn, J., Hornburg, D., Rego, S., Perelman, D., Ahadi, S., Sailani, M. R., Zhou, Y., Leopold, S. R., Chen, J., Ashland, M., Christle, J. W., Avina, M., Limcaoco, P., Ruiz, C., Tan, M., Butte, A. J., Weinstock, G. M., Slavich, G. M., Sodergren, E., McLaughlin, T. L., Haddad, F., Snyder, M. P. 2019; 25 (5): 792–804

    Abstract

    Precision health relies on the ability to assess disease risk at an individual level, detect early preclinical conditions and initiate preventive strategies. Recent technological advances in omics and wearable monitoring enable deep molecular and physiological profiling and may provide important tools for precision health. We explored the ability of deep longitudinal profiling to make health-related discoveries, identify clinically relevant molecular pathways and affect behavior in a prospective longitudinal cohort (n = 109) enriched for risk of type 2 diabetes mellitus. The cohort underwent integrative personalized omics profiling from samples collected quarterly for up to 8 years (median, 2.8 years) using clinical measures and emerging technologies including genome, immunome, transcriptome, proteome, metabolome, microbiome and wearable monitoring. We discovered more than 67 clinically actionable health discoveries and identified multiple molecular pathways associated with metabolic, cardiovascular and oncologic pathophysiology. We developed prediction models for insulin resistance by using omics measurements, illustrating their potential to replace burdensome tests. Finally, study participation led the majority of participants to implement diet and exercise changes. Altogether, we conclude that deep longitudinal profiling can lead to actionable health discoveries and provide relevant information for precision health.

    View details for PubMedID 31068711

  • Canagliflozin review - safety and efficacy profile in patients with T2DM DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY Jakher, H., Chang, T. I., Tan, M., Mahaffey, K. W. 2019; 12: 209–15
  • Canagliflozin review - safety and efficacy profile in patients with T2DM. Diabetes, metabolic syndrome and obesity : targets and therapy Jakher, H., Chang, T. I., Tan, M., Mahaffey, K. W. 2019; 12: 209–15

    Abstract

    Canagliflozin is a sodium glucose-cotransporter (SGLT) receptor inhibitor approved for the treatment of type 2 diabetes mellitus (T2DM). This article reviews the mechanism of action of SGLT-2 receptor inhibitors and the efficacy of canagliflozin as an antidiabetic agent, its cardiovascular and renal benefits, and safety profile. During the development of canagliflozin, Phase II trials showed an improvement in cardiac and renal biomarkers such as blood pressure, body weight, and albuminuria. The large CANVAS program showed that canagliflozin reduced the composite cardiovascular outcome of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke. The CANVAS program also showed a possible benefit of canagliflozin on a renal composite of sustained 40% reduction in estimated glomerular filtration rate, the need for renal replacement therapy, or death from renal causes. The safety profile of canagliflozin has been well characterized, and known side effects such as mycotic genital infections were confirmed in CANVAS. However, an increased risk of amputations was observed in CANVAS that requires further study. Overall, canagliflozin is an effective antidiabetic medication with cardiovascular and likely renal benefits, and with a generally well-tolerated safety profile. Results from the CREDENCE trial will further evaluate the safety and potential renal benefits of canagliflozin in patients with established diabetic nephropathy.

    View details for PubMedID 30787627

  • Effect of Electronic Clinical Decision Support on 25(OH) Vitamin D Testing. Journal of general internal medicine Chin, K. K., Hom, J., Tan, M., Sharp, C., Wang, S., Chen, Y. R., Chen, D. 2019

    View details for PubMedID 31090033

  • Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial. Lancet (London, England) Hernandez, A. F., Green, J. B., Janmohamed, S., D'Agostino, R. B., Granger, C. B., Jones, N. P., Leiter, L. A., Rosenberg, A. E., Sigmon, K. N., Somerville, M. C., Thorpe, K. M., McMurray, J. J., Del Prato, S. 2018; 392 (10157): 1519–29

    Abstract

    Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke.We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30-50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515.Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68-0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group.In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes.GlaxoSmithKline.

    View details for DOI 10.1016/S0140-6736(18)32261-X

    View details for PubMedID 30291013

  • Acromegalic cardiomyopathy: Epidemiology, diagnosis, and management. Clinical cardiology Sharma, A. N., Tan, M., Amsterdam, E. A., Singh, G. D. 2018; 41 (3): 419–25

    Abstract

    Acromegalic cardiomyopathy is the leading cause of morbidity and all-cause mortality in patients with acromegaly. Though acromegaly is a rare condition, the associated derangements are vast and severe. Stemming from an increase in circulating growth hormone (GH) and insulin-like growth factor-1 levels (IGF-1), acromegalic cardiomyopathy results in pathological changes in myocyte growth and structure, cardiac contractility, and vascular function. These molecular changes manifest commonly as biventricular hypertrophy, diastolic and systolic dysfunction, and valvular regurgitation. Early recognition of the condition is paramount, though the insidious progression of the disease commonly results in a late diagnosis. Biochemical testing, based on IGF-1 measurements, is the gold standard of diagnosis. Management should be centered on normalizing serum levels of both IGF-1 and GH. Transsphenoidal resection remains the most cost-effective and permanent treatment for acromegaly, though medical therapy possesses benefit for those who are not surgical candidates. Ultimately, achieving control of hormone levels results in a severe reduction in mortality rate, underscoring the importance of early recognition and treatment.

    View details for PubMedID 29574794

  • Power Failure: Acromegalic Cardiomyopathy. The American journal of medicine Mantri, N. M., Amsterdam, E., Tan, M., Singh, G. D. 2016

    View details for PubMedID 27039953

  • Does Polycystic Ovarian Syndrome Increase Insulin Resistance Above and Beyond Obesity? Endocrinology and Metabolic Syndrome Tan, M., Kim, S. H. 2014; 3 (142)
  • Patient whiteboards to improve patient-centred care in the hospital. Postgraduate medical journal Tan, M., Hooper Evans, K., Braddock, C. H., Shieh, L. 2013; 89 (1056): 604-609

    Abstract

    Patient whiteboards facilitate communication between patients and hospital providers, but little is known about their impact on patient satisfaction and awareness. Our objectives were to: measure the impact in improving patients' understanding of and satisfaction with care; understand barriers for their use by physicians and how these could be overcome; and explore their impact on staff and patients' families.In 2012, we conducted a 3-week pilot of multidisciplinary whiteboard use with 104 inpatients on the general medicine service at Stanford University Medical Center. A brief, inperson survey was conducted with two groups: (1) 56 patients on two inpatient units with whiteboards and (2) 48 patients on two inpatient units without whiteboards. Questions included understanding of: physician name, goals of care, discharge date and satisfaction with care. We surveyed 25 internal medicine residents regarding challenges of whiteboard use, along with physical therapists, occupational therapists, case managers, consulting physicians and patients' family members (n=40).The use of whiteboards significantly increased the proportion of patients who knew: their physician (p≤=0.0001), goals for admission (p≤=0.0016), their estimated discharge date (p≤=0.049) and improved satisfaction with the hospital stay overall (p≤=0.0242). Physicians, ancillary staff and patient families all found the whiteboards to be helpful. In response, residents were also more likely to integrate whiteboard use into their daily work flow.Inpatient whiteboards help physicians and ancillary staff with communication, improve patients' awareness of their care team, admission plans and duration of admission, and significantly improve patient overall satisfaction.

    View details for DOI 10.1136/postgradmedj-2012-131296

    View details for PubMedID 23922397

  • Metastatic Burkitt's lymphoma presenting as diabetes insipidus. Endocrine practice Tan, M. J., Aguinaldo, T. F. 2013; 19 (4): e102-4

    Abstract

    Objective: To present the first reported case of metastatic Burkitt's lymphoma with a single central nervous system (CNS) metastasis to the pituitary stalk.Methods: Case presentation, review of literature.Results: Though other malignancies are known to metastasize to the pituitary, and diabetes insipidus is often the presenting symptom, there has not been a previously reported case of Burkitt's lymphoma with a single CNS metastasis to the pituitary.Conclusion: A careful history and endocrine review of systems may aid early identification of pituitary or central nervous system metastases.

    View details for DOI 10.4158/EP12438.CR

    View details for PubMedID 23512390

  • Malignant Pheochromocytoma Presenting as Incapacitating Bony Pain PAIN PRACTICE Tan, M., Camargo, C. A., Mojtahed, A., Mihm, F. 2012; 12 (4): 286-289

    Abstract

    Among adrenal incidentalomas, pheochromocytomas are rare. Malignant pheochromocytoma is even less common, and it typically presents with classic hormonal symptoms, such as palpitations, labile blood pressures, and headaches. Bony metastasis usually occurs late in disease, but we report an unusual case of incapacitating bony pain as the initial presentation of malignant pheochromocytoma. Our patient is a 70-year-old woman with neurofibromatosis type 1 and a history of primary hyperparathyroidism, who tested negative for the ret mutation. She came to medical attention with chest pain and palpitations and was incidentally found to have an adrenal mass. Serum and urine testing was consistent with pheochromocytoma. Her blood pressure was easily controlled as she awaited elective adrenalectomy; however, she quickly developed severe, diffuse bony pain. She represented with hypercalcemia, spontaneous fractures, and incapacitating pain that required such high doses of pain medications that she had to be intubated. Further imaging and bone marrow biopsy confirmed metastatic neuroendocrine tumor. She received one round of chemotherapy with no change in her bony pain, which was her primary complaint. Unfortunately, her treatment options were limited by the heavy sedation required for comfort, and in the end, it was her bony pain rather than hormonal symptoms that made her disease untreatable.

    View details for DOI 10.1111/j.1533-2500.2011.00499.x

    View details for PubMedID 21884564