Filling the Gap: The Importance of Medicaid Continuity for Former Inmates
JOURNAL OF GENERAL INTERNAL MEDICINE
2009; 24 (7): 860-862
Visual experience regulates transient expression and dendritic localization of Fragile X mental retardation protein
JOURNAL OF NEUROSCIENCE
2004; 24 (47): 10579-10583
Despite no federal law mandating Medicaid termination for prisoners, 90 percent of states have implemented policies that withdraw inmates' enrollment upon incarceration. This leaves a medically and psychiatrically vulnerable population uninsured during the months following release, a time period during which former inmates have been shown to have an increased risk of medical problems and death. We believe it is of critical importance for the 10 million Americans who cycle in and out of corrections each year, as well as the communities they return to, that Medicaid be suspended rather than terminated during incarceration.
View details for DOI 10.1007/s11606-009-0977-x
View details for Web of Science ID 000266948900013
View details for PubMedID 19381728
Fragile X syndrome is the most common form of inherited mental retardation and is caused by the loss of function of the Fragile X mental retardation protein (FMRP). FMRP is an RNA binding protein thought to play a key role in protein synthesis-dependent synaptic plasticity. The regulation of FMRP expression itself is also likely to be an important control point in this process. Here we used dark-reared/light-exposed rats to determine the role of experience in regulating FMRP levels in the visual cortex. We find that FMRP levels increase in the cell bodies and dendrites of visual cortical neurons after as little as 15 min of light exposure. Remarkably, FMRP expression in these neurons returns to baseline levels by 30 min of light exposure. These changes were post-transcriptional because the FMR1 mRNA levels remained constant over this time period. A transient increase in FMRP levels was also observed in synaptic fractions prepared from visual cortices of light-exposed animals. In contrast, alpha-calcium/calmodulin-dependent kinase II expression showed a sustained upregulation under these conditions. Finally, the increase in FMRP expression was inhibited by blockade of NMDA receptors. This tight temporal-spatial regulation suggests that FMRP plays a dynamic role in a distinct epoch of experience-dependent synaptic plasticity.
View details for DOI 10.1523/JNEUROSCI.2185-04.2004
View details for Web of Science ID 000225333100002
View details for PubMedID 15564573