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GU and Gyn clinical imaging
Serial Ultrasound of Solid Tumor Lesions to Detect Early Response to Cancer Immunotherapy
Primary objective is to assess whether changes in quantitative tumor perfusion parameters
after 3 weeks of treatment, as measured by CEUS, can predict initial objective response to
therapy, defined by current standard-of-care
Secondary objectives are to evaluate if there is an optimal ultrasound imaging modality (CEUS
or conventional power Doppler or LEAD ultrasound) or optimal time point to predict initial
objective response and to assess the correlation of tumor perfusion parameters with change in
overall tumor burden, change in diameter on a per-lesion basis, and with 12-month
progression-free survival (PFS).
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