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Instructor, Medicine - Nephrology
Medicine - Nephrology
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Profiles With Related Publications
Assistant Professor (Research) of Pathology
Our goal is to understand the mechanisms regulating the development of human systems. Drawing on both pluripotent stem cell biology, hematopoiesis, and immunology, combined with novel high-content single-cell analysis (CyTOF – Mass Cytometry) and imagining (MIBI-Multiplexed Ion Beam Imaging) we are creating templates of ‘normal’ human cellular behavior to both discover novel regulatory events and cell populations as well as understand dysfunctional processes such as cancer.
Klaus Bensch Professor of Pathology
Our interests include:
1) The physiology and function of lymphocyte homing in local and systemic immunity;
2) Biochemical and genetic studies of molecules that direct leukocyte recruitment;
3) Chemotactic mechanisms and receptors in vascular and immune biology;
4) Vascular control of normal and pathologic inflammation and immunity;
5) Systems biology of immune cell trafficking and programming in tumor immunity.
Professor of Microbiology & Immunology
Contribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses.
David Korn, MD, Professor of Pathology and Professor of Developmental Biology
Chromatin regulation and its roles in human cancer and the development of the nervous system. Engineering new methods for studying and controlling chromatin in living cells.
Professor of Pathology and of Medicine (Immunology and Rheumatology)
Dendritic cells, macrophages, NK cells and T cells; functional proteins and genes; immunotherapeutic approaches to cancer, autoimmune disease, neurodegenerative disease and metabolic disease.
C. Garrison Fathman
Professor of Medicine (Immunology and Rheumatology), Emeritus
My lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity. We have identified and characterized a gene (GRAIL) that seems to control regulatory T cell (Treg) responsiveness by inhibiting the Treg IL-2 receptor desensitization. We have characterized a gene (Deaf1) that plays a major role in peripheral tolerance in T1D. Using PBC gene expression, we have provisionally identified a signature of risk and progression in T1D.
Leonore A. Herzenberg
Department of Genetics Flow Cytometry Professor
B-cell lineage development and function; IgH rearrangement and repertoire analysis; HSC and lymphoid stem cells and lineages in mouse and man; T cell regulation of antibody responses; glutathione regulation of lymphoid and myeloid subst functions; development of advanced methods and software for Fluorescence-Activated Cell Sorting (FACS) and related analyses.
Clinical Associate Professor, Pathology
Anatomic Pathology, Surgical Pathology, Urological Pathology, Soft Tissue Pathology, Molecular Pathology
Ronald Levy, MD
Robert K. and Helen K. Summy Professor in the School of Medicine
Cancer > Lymphoma, Lymphoma , Non-Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma - Medical Oncology, Burkitt's Lymphoma, Burkitt's Lymphoma - Medical Oncology, Hodgkin's Disease, Hodgkin's Disease - Medical Oncology, Burkitt's Lymphoma - Hematology, Hodgkin's Disease - Hematology, Oncology (Cancer), Non-Hodgkin's Lymphoma - Hematology, Medical Oncology
Clinical Interests: lymphoma. Research Interests: Immunology and molecular biology of lymphoid malignancy; molecular vaccines for cancer.
David B. Lewis
Professor of Pediatrics (Immunology)
Primary Immunodeficiency, Pediatrics
My laboratory is focused on defining cellular and molecular mechanisms that limit T cell responses to vaccines and pathogens during normal early postnatal development and in cases of inherited genetic immunodeficiencies. We are also determinomg how these limitations in immunity can be overcome by using novel approaches for vaccine adjuvants for influenza vaccine and by using catalytically inactive Cas proteins for inducing endogenous gene expression.
Ernest and Amelia Gallo Family Professor and Professor of Pediatrics and of Medicine
Recent clinical studies, by us and others, have demonstrated that genetically engineered T cells can eradicate cancers resistant to all other therapies. We are identifying new targets for these therapeutics, exploring pathways of resistance to current cell therapies and creating next generation platforms to overcome therapeutic resistance. We have discovered novel insights into the biology of human T cell exhaustion and developed approaches to prevent and reverse this phenomenon.
Publication Topics For This Person
Gene Expression Regulation
Gene Rearrangement, T-Lymphocyte
Inducible T-Cell Co-Stimulator Protein
Mice, Inbred C57BL
Polymerase Chain Reaction
Proto-Oncogene Proteins c-bcl-6
Receptors, Antigen, T-Cell
Reverse Transcriptase Polymerase Chain Reaction
Somatic Hypermutation, Immunoglobulin