Bio

Professional Education


  • Doctor of Philosophy, University of Oxford (2017)

Stanford Advisors


Publications

All Publications


  • Biased interpretations of ambiguous bodily threat information in adolescents with chronic pain. Pain Heathcote, L. C., Jacobs, K., Eccleston, C., Fox, E., Lau, J. Y. 2017; 158 (3): 471-478

    Abstract

    Adult patients with chronic pain are consistently shown to interpret ambiguous health and bodily information in a pain-related and threatening way. This interpretation bias may play a role in the development and maintenance of pain and disability. However, no studies have yet investigated the role of interpretation bias in adolescent patients with pain, despite that pain often first becomes chronic in youth. We administered the Adolescent Interpretations of Bodily Threat (AIBT) task to adolescents with chronic pain (N = 66) and adolescents without chronic pain (N = 74). Adolescents were 10 to 18 years old and completed the study procedures either at the clinic (patient group) or at school (control group). We found that adolescents with chronic pain were less likely to endorse benign interpretations of ambiguous pain and bodily threat information than adolescents without chronic pain, particularly when reporting on the strength of belief in those interpretations being true. These differences between patients and controls were not evident for ambiguous social situations, and they could not be explained by differences in anxious or depressive symptoms. Furthermore, this interpretation pattern was associated with increased levels of disability among adolescent patients, even after controlling for severity of chronic pain and pain catastrophizing. The current findings extend our understanding of the role and nature of cognition in adolescent pain, and provide justification for using the AIBT task in longitudinal and training studies to further investigate causal associations between interpretation bias and chronic pain.

    View details for DOI 10.1097/j.pain.0000000000000781

    View details for PubMedID 28067692

  • Pain and cancer survival: a cognitive-affective model of symptom appraisal and the uncertain threat of disease recurrence. Pain Heathcote, L. C., Eccleston, C. 2017

    View details for DOI 10.1097/j.pain.0000000000000872

    View details for PubMedID 28195857

  • Antidepressants for chronic non-cancer pain in children and adolescents (Protocol) Cochrane Database of Systematic Reviews Cooper, T. E., Heathcote, L. C., Clinch, J., Gold, J., Howard, R., Lord, S., Schechter, N., Wood, C., Wiffen, P. J. 2017; 2
  • Non-steroidal anti-inflammatory drugs (NSAIDs) for cancer-related pain in children and adolescents (Protocol) Cochrane Database of Systematic Reviews Cooper, T. E., Heathcote, L. C., Anderson, B., Gregoire, M., Eccleston, C. 2017; 2
  • Biased interpretations of ambiguous bodily threat information in adolescents with chronic pain Pain Heathcote, L. C., Jacobs, K., Eccleston, C., Fox, E., Lau, J. Y. 2017; 158 (3): 471-478
  • Pain and cancer survival: A cognitive-affective model of symptom appraisal and the uncertain threat of disease recurrence Pain Heathcote, L. C., Eccleston, C. 2017
  • Antiepileptic drugs for chronic non-cancer pain in children and adolescents (Protocol) Cochrane Database of Systematic Reviews Wiffen, P. J., Cooper, T. E., Heathcote, L. C., Clinch, J., Howards, R., Krane, E., Lord, S., Sethna, N., Schecter, N., Wood, C. 2017; 2
  • Child attention to pain and pain tolerance are dependent upon anxiety and attention control: An eye-tracking study European Journal of Pain Heathcote, L. C., Lau, J. Y., Mueller, S. C., Fox, E., Bosmans, M., Vervoort, T. 2017; 21 (2): 250-263

    View details for DOI 10.1002/ejp.920

  • Pain Neuroscience Education: State of the Art and Application in Pediatrics. Children (Basel, Switzerland) Robins, H., Perron, V., Heathcote, L. C., Simons, L. E. 2016; 3 (4)

    Abstract

    Chronic pain is a widespread problem in the field of pediatrics. Many interventions to ameliorate pain-related dysfunction have a biobehavioral focus. As treatments for chronic pain (e.g., increased movement) often stand in stark contrast to treatments for an acute injury (e.g., rest), providing a solid rationale for treatment is necessary to gain patient and parent buy-in. Most pain treatment interventions incorporate psychoeducation, or pain neuroscience education (PNE), as an essential component, and in some cases, as a stand-alone approach. The current topical review focuses on the state of pain neuroscience education and its application to pediatric chronic pain. As very little research has examined pain neuroscience education in pediatrics, we aim to describe this emerging area and catalyze further work on this important topic. As the present literature has generally focused on adults with chronic pain, pain neuroscience education merits further attention in the realm of pediatric pain in order to be tailored and implemented in this population.

    View details for DOI 10.3390/children3040043

    View details for PubMedID 28009822

    View details for PubMedCentralID PMC5184818

  • Negative Interpretation Bias and the Experience of Pain in Adolescents JOURNAL OF PAIN Heathcote, L. C., Koopmans, M., Eccleston, C., Fox, E., Jacobs, K., Wilkinson, N., Lau, J. Y. 2016; 17 (9): 972-981

    Abstract

    Negative interpretation bias, the tendency to appraise ambiguous situations in a negative or threatening way, has been suggested to be important for the development of adult chronic pain. To our knowledge, this is the first study to examine the role of a negative interpretation bias in adolescent pain. We first developed and piloted a novel task that measures the tendency for adolescents to interpret ambiguous situations as indicative of pain and bodily threat. Using this task in a separate community sample of adolescents (N = 115), we then found that adolescents who catastrophize about pain, as well as those who reported more pain issues in the preceding 3 months, were more likely to endorse negative interpretations, and less likely to endorse benign interpretations, of ambiguous situations. This interpretation pattern was not, however, specific for situations regarding pain and bodily threat, but generalized across social situations as well. We also found that a negative interpretation bias, specifically in ambiguous situations that could indicate pain and bodily threat, mediated the association between pain catastrophizing and recent pain experiences. Findings may support one potential cognitive mechanism explaining why adolescents who catastrophize about pain often report more pain.This article presents a new adolescent measure of interpretation bias. We found that the tendency to interpret ambiguous situations as indicative of pain and bodily threat may be one potential cognitive mechanism explaining why adolescents who catastrophize about pain report more pain, thus indicating a potential novel intervention target.

    View details for DOI 10.1016/j.jpain.2016.05.009

    View details for Web of Science ID 000382796000003

    View details for PubMedID 27263991

  • Pain neuroscience education: State of the art and application in pediatrics Children Robins, H., Perron, V., Heathcote, L. C., Simons, L. E. 2016; 3 (43)

    View details for DOI 10.3390/children3040043

  • High trait anxiety during adolescence interferes with discriminatory context learning NEUROBIOLOGY OF LEARNING AND MEMORY Kadosh, K. C., Haddad, A. D., Heathcote, L. C., Murphy, R. A., Pine, D. S., Lau, J. Y. 2015; 123: 50-57

    Abstract

    Persistent adult anxiety disorders often begin in adolescence. As emphasis on early treatment grows, we need a better understanding of how adolescent anxiety develops. In the current study, we used a fear conditioning paradigm to identify disruptions in cue and context threat-learning in 19 high anxious (HA) and 24 low anxious (LA) adolescents (12-17years). We presented three neutral female faces (conditioned stimulus, CS) in three contingent relations with an unconditioned stimulus (UCS, a shrieking female scream) in three virtual room contexts. The degree of contingency between the CSs and the UCSs varied across the rooms: in the predictable scream condition, the scream followed the face on 100% of trials; in the unpredictable scream condition, the scream and face appeared randomly and independently of each other; in the no-scream condition the CS was presented in the absence of any UCS. We found that the LA adolescents showed higher levels of fear-potentiated startle to the faces relative to the rooms. This difference was independent of the contingency condition. The HA adolescents showed non-differential startle between the CSs, but, in contrast to previous adult data, across both cue types displayed lowest startle to the unpredictable condition and highest startle to the no-scream condition. Our study is the first to examine context conditioning in adolescents, and our results suggest that high trait anxiety early in development may be associated with an inability to disambiguate the signalling roles of cues and contexts, and a mislabelling of safety or ambiguous signals.

    View details for DOI 10.1016/j.nlm.2015.05.002

    View details for Web of Science ID 000359510900007

    View details for PubMedID 25982943

  • The puzzle of attentional bias to pain: beyond attention PAIN Crombez, G., Heathcote, L. C., Fox, E. 2015; 156 (9): 1581-1582
  • The relationship between adolescents' pain catastrophizing and attention bias to pain faces is moderated by attention control PAIN Heathcote, L. C., Vervoort, T., Eccleston, C., Fox, E., Jacobs, K., Van Ryckeghem, D. M., Lau, J. Y. 2015; 156 (7): 1334-1341

    Abstract

    This study considered the attentional functioning of adolescents with varying levels of pain catastrophizing. Specifically, we investigated the relationship between pain catastrophizing and attention bias to pain facial expressions. Furthermore, drawing on dual process models in the context of pain, we investigated the moderating role of attention control on this relationship. Adolescents (N = 73; age, 16-18 years) performed a dot-probe task in which facial expressions of pain and neutral expressions were presented for 100 milliseconds and 1250 milliseconds. Participants also completed self-report pain catastrophizing and attention control measures. We found that although there was no main effect of pain catastrophizing on attention bias towards pain faces, attention control did significantly moderate this relationship. Further analysis revealed that lower levels of attention control were significantly associated with increasing attentional vigilance towards pain faces only within high catastrophizing adolescents. In addition, we found that poorer attention control was related to increased attention bias for pain faces (regardless of pain catastrophizing level) when these faces were presented for relatively longer durations (ie, 1250 milliseconds) but not for short durations (ie, 100 milliseconds). This study supports a dual process model of attentional processes in pain, thus replicating previous findings within the psychopathology literature but extending them to the study of pain. Theoretical and clinical implications of our findings are discussed.

    View details for DOI 10.1097/j.pain.0000000000000174

    View details for Web of Science ID 000357426200020

    View details for PubMedID 25830926

  • Systematic Review and Meta-Analysis of Psychological Therapies for Children With Chronic Pain JOURNAL OF PEDIATRIC PSYCHOLOGY Fisher, E., Heathcote, L., Palermo, T. M., Williams, A. C., Lau, J., Eccleston, C. 2014; 39 (8): 763-782

    Abstract

    This systematic review and meta-analysis examined the effects of psychological therapies for management of chronic pain in children. Randomized controlled trials of psychological interventions treating children (<18 years) with chronic pain conditions including headache, abdominal, musculoskeletal, or neuropathic pain were searched for. Pain symptoms, disability, depression, anxiety, and sleep outcomes were extracted. Risk of bias was assessed and quality of the evidence was rated using GRADE. 35 included studies revealed that across all chronic pain conditions, psychological interventions reduced pain symptoms and disability posttreatment. Individual pain conditions were analyzed separately. Sleep outcomes were not reported in any trials. Optimal dose of treatment was explored. For headache pain, higher treatment dose led to greater reductions in pain. No effect of dosage was found for other chronic pain conditions. Evidence for psychological therapies treating chronic pain is promising. Recommendations for clinical practice and research are presented.

    View details for DOI 10.1093/jpepsy/jsu008

    View details for Web of Science ID 000343398100002

    View details for PubMedID 24602890

  • Age-related changes in attentional control across adolescence: how does this impact emotion regulation capacities? Frontiers in psychology Cohen Kadosh, K., Heathcote, L. C., Lau, J. Y. 2014; 5: 111-?

    Abstract

    This study set out to establish the novel use of the go/no-go Overlap task for investigating the role of attentional control capacities in the processing of emotional expressions across different age-groups within adolescence: at the onset of adolescence (11-12 year-olds) and toward the end of adolescence (17-18 year-olds). We also looked at how attentional control in the processing of fearful, happy, and neutral expressions relates to individual differences in trait anxiety in these adolescent groups. We were able to show that younger adolescents, but not older adolescents had more difficulties with attention control in the presence of all faces, but particularly in the presence of fearful faces. Moreover, we found that across all groups, adolescents with higher trait anxiety exhibited attentional avoidance of all faces, which facilitated relatively better performance on the primary task. These differences in reaction time emerged in the context of comparable accuracy level in the primary task across age-groups. Our results contribute to our understanding of how attentional control abilities to faces but in particular fearful expressions may mature across adolescence. This may affect learning about the environment and the acquisition of behavioral response patterns in the social world.

    View details for DOI 10.3389/fpsyg.2014.00111

    View details for PubMedID 24575077