Kendric C. Smith

Professor of Radiation Oncology, Emeritus

Academic Appointments

Emeritus Faculty, Acad Council, Radiation Oncology

Current Research and Scholarly Interests

The photochemistry and radiation chemistry of DNA, the genetic control and biochemical bases of the multiple pathways of DNA repair, and the roles of DNA repair processes in radiation and spontaneous mutagenesis. Over 190 papers have been published on these and related topics.

All Publications

Profiles With Related Publications

close
Jon Bernstein

Professor of Pediatrics (Genetics) and, by courtesy, of Genetics
Clinical Focus
Autism, Developmental Disorders, Undiagnosed Diseases, Craniofacial Conditions, Craniosynostosis, Cleft Lip, Cleft Palate, Medical Biochemical Genetics
Research Interests
My research is focused on the diagnosis, discovery and delineation of rare genetic conditions with a focus of neurodevelopmental disorders. This work includes the application of novel computational methods and multi-omics profiling (whole genome sequencing, RNA sequencing, metabolomics). I additionally participate in an interdisciplinary project to develop induced pluripotent stem cell (iPSC) models of genetic neurodevelopmental disorders..

145 Total Publications
close
Michele Calos

Professor of Genetics, Emerita
Research Interests
My lab is developing innovative gene and stem cell therapies for genetic diseases, with a focus on gene therapy and regenerative medicine.

We have created novel methods for inserting therapeutic genes into the chromosomes at specific places by using homologous recombination and recombinase enzymes.

We are working on 3 forms of muscular dystrophy.

We created induced pluripotent stem cells from patient fibroblasts, added therapeutic genes, differentiated, and engrafted the cells.

134 Total Publications
close
Sophia Chernikova

Sr Res Scientist-Basic Ls, Neurosurgery

19 Total Publications
close
Gilbert Chu

Professor of Medicine (Oncology) and of Biochemistry
Research Interests
After shuttering the wet lab, we have focused on: a point-of-care device to measure blood ammonia and prevent brain damage; a human protein complex that juxtaposes and joins DNA ends for repair and V(D)J recombination; and strategies for teaching students and for reducing selection bias in educational programs.

74 Total Publications
close
Karlene Cimprich

Professor of Chemical and Systems Biology and, by courtesy, of Biochemistry
Research Interests
Genomic instability contributes to many diseases, but it also underlies many natural processes. The Cimprich lab is focused on understanding how mammalian cells maintain genomic stability in the context of DNA replication stress and DNA damage. We are interested in the molecular mechanisms underlying the cellular response to replication stress and DNA damage as well as the links between DNA damage and replication stress to human disease.

75 Total Publications
close
Stanley N. Cohen, MD

Kwoh-Ting Li Professor in the School of Medicine, Professor of Genetics and of Medicine
Research Interests
We study mechanisms that affect the expression and decay of normal and abnormal mRNAs, and also RNA-related mechanisms that regulate microbial antibiotic resistance. A small bioinformatics team within our lab has developed knowledge based systems to aid in investigations of genes.

333 Total Publications
close
Uta Francke

Professor of Genetics and of Pediatrics, Emerita
Clinical Focus
Neurogenetics, Clinical Genetics, Marfan syndrome, Williams syndrome, Heritable connective tissue disorders
Research Interests
Functional consequences and pathogenetic mechanisms of mutations and microdeletions in human neurogenetic syndromes and mouse models. Integration of genomic information into medical care.

564 Total Publications
close
Philip C. Hanawalt

Dr. Morris Herzstein Professor in Biology, Emeritus
Research Interests
My current interest includes two principal areas:

1. The molecular basis for diseases in which the pathway of transcription-coupled DNA repair is defective, including Cockyne syndrome (CS) and UV-sensitive syndrome (UVSS). Patients are severely sensitive to sunlight but get no cancers. See Hanawalt & Spivak, 2008, for review.

2. Transcription arrest by guanine-rich DNA sequences and non-canonical secondary structures. Transcription collisions with replication forks.

241 Total Publications
close
Christine Jacobs-Wagner

Dennis Cunningham Professor, Professor of Biology and of Microbiology and Immunology

86 Total Publications
close
Daniel Jarosz

Associate Professor of Chemical and Systems Biology and of Developmental Biology
Research Interests
My laboratory studies conformational switches in evolution, disease, and development. We focus on how molecular chaperones, proteins that help other biomolecules to fold, affect the phenotypic output of genetic variation. To do so we combine classical biochemistry and genetics with systems-level approaches. Ultimately we seek to understand how homeostatic mechanisms influence the acquisition of biological novelty and identify means of manipulating them for therapeutic and biosynthetic benefit.

57 Total Publications
close
Alexandra (Sasha) Khristich

Postdoctoral Scholar, Biology

6 Total Publications
close
Eric Kool

George A. and Hilda M. Daubert Professor of Chemistry
Research Interests
• Design of cell-permeable reagents for profiling, modifying, and controlling RNAs
• Developing fluorescent probes of DNA repair pathways, with applications in cancer, aging, and neurodegenerative disease
• Discovery and development of small-molecule modulators of DNA repair enzymes, with focus on cancer and inflammation

371 Total Publications