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Dr. Kanwaljeet Anand graduated from M.G.M. Medical College, Indore (India). As a Rhodes Scholar at University of Oxford, he received the D.Phil. degree, followed by post-doctoral fellowship at Harvard Medical School, Pediatrics residency training at Boston Children’s Hospital and a Critical Care Medicine fellowship at the Massachusetts General Hospital, Boston. His research was recognized by the Dr. Michael Blacow Award from British Paediatric Association (1986), Pediatric Resident Research Award from American Academy of Pediatrics (1992), the inaugural Young Investigator Award in Pediatric Pain from International Association for Study of Pain (IASP, 1994), the Jeffrey Lawson Award for Children’s Advocacy from American Pain Society (2000), the Windermere Honorary Lectureship Award from Royal College of Paediatrics & Child Health (2004), Joan M. Cranmer “Mentor of the Year” Award (2007) from University of Arkansas, the Nils Rosén von Rosenstein Award* from the Swedish Academy of Medicine (2009), Top Mentor Award, School of Graduate Studies, University of Arkansas for Medical Sciences (2011), the 9th Annual “In Praise of Medicine” Public Address at Erasmus University (2014), the Journées Nationales de Néonatologie 2015 Address at The Pasteur Institute (Paris, France), the Nightingale Excellence Award (2016) from Stanford Children’s Healthcare, and an Honorary Doctorate from University of Örebro, Sweden (2019). Dr. Anand founded the Harmony Health Clinic, the largest charitable medical & dental clinic in Little Rock and worked to remove inter-faith conflict throughout the state of Arkansas. He received the Father Joseph Biltz Award (2007) from the National Conference for Community & Justice (NCCJ) and the Dr. Martin Luther King “Salute to Greatness” Individual Award (2008) from the Governor of Arkansas for his commitments to community service. Dr. Anand is currently Professor of Pediatrics, Anesthesiology, Perioperative & Pain Medicine at Stanford University School of Medicine; he directs the Pain/Stress Neurobiology Lab, the Jackson Vaughan Critical Care Research Fund, and serves as Editor for the journal Pediatric Research. He is considered a world authority on pain/stress in newborns and pain management in infants.
We are looking to engage healthy preschool children (aged 9 to 72 months) for research on measuring wellness in early childhood. We have worked with hundreds of families to date and want to partner with families and individuals with preschool children! We are studying the positive and negative experiences of young children by measuring hormones, proteins, or other molecules present in the hair samples that are painlessly obtained from children and their parents. To minimize the possibility of transmitting the COVID-19 virus, our “contact-free” study enrollment will guide participants how to:•Give informed consent using electronic signatures on the IRB-approved consent form;•Obtain a hair sample (pain-free method using a trimmer) from parent(s) and children;•Measure and record each child’s height and weight; and•Complete online questionnaires telling us about the parent(s) and their children. As a token of our gratitude, we will provide every child with a “Junior Scientist Certificate” and parents receive Gift Cards of $50 (for each child) and $25 for parent hair samples. All sessions can take place via Zoom, phone, or in-person at a location suitable to the parents/family. If anyone is interested in this research, either click on: https://tinyurl.com/HairBiomarkerStudy, or email us at: HairBiomarkers@lists.stanford.edu, or call us at: (650) 687-7329.
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Adolescents are motivated by sensation- or novelty-seeking behaviors, peer relationships, and social status, associated with heightened emotional instability and stress responsivity, sleep and circadian rhythm changes, and impaired judgements due to an underdeveloped prefrontal cortex. We are testing an evidence-based biopsychosocial intervention designed to build social-emotional skills, self-mastery, and resilience, thus enhancing prosocial behaviors, emotional control, conflict resolution, and healthy behaviors. This includes a mind-body-lifestyle curriculum, daily breathing practices, and individual student supports, to promote self-esteem and protect against the effects of poverty or racism.We will test whether this SKY Schools Program reduces perceived stress, anxiety, depression, and risky behaviors, while improving self-esteem, school discipline, and healthy behaviors as compared to pre-intervention values. We will investigate the mechanisms of these effects by studying if children with greater perceived stress, anxiety, and risky behaviors will show higher stress hormones, whereas those with greater emotional regulation and self-esteem will show higher socializing hormones.7th Grade students (aged 11-14 years) will be enrolled from a school that has high numbers of children from socially disadvantaged and/or minority families. Students, parents, and teachers will complete surveys at the school start (October), after Winter Break (January), and when the school year ends (June); hair samples will be obtained painlessly from the enrolled students at these time-points. The SKY Schools Program will be delivered after Winter Break via daily 1-hour sessions for 4 weeks in January, followed by weekly refresher sessions, and individual student support until the school year ends. By comparing their risk factors, behaviors and outcomes before and after the proposed program, we will develop scientific insights into chronic stress and social isolation as causative factors for youth risk-taking, test the effectiveness of an evidence-based biopsychosocial intervention designed to counteract these behaviors, and ultimately help to improve the health, wellbeing, and academic outcomes of all socially disadvantaged adolescents.
Dr. Anand is a translational clinical researcher who pioneered research on the endocrine-metabolic stress responses of infants undergoing surgery and developed the first-ever scientific rationale for pain perception in early life. This provided a framework for newer methods of pain assessment, numerous clinical trials of analgesia/anesthesia in newborns, infants and older children. His research focus over the past 30+ years has contributed fundamental knowledge about pediatric pain/stress, long-term effects of pain in early life, management of pain, mechanisms for opioid tolerance and withdrawal. Current projects in his laboratory are focused on developing biomarkers for repetitive pain/stress in critically ill children and the mechanisms underlying sedative/anesthetic neurotoxicity in the immature brain. He designed and directed many randomized clinical trials (RCT), including the largest-ever pediatric analgesia trial studying morphine therapy in ventilated preterm neonates. He has extensive experience in clinical and translational research from participating in collaborative networks funded by NIMH, NINDS, or NICHD, a track-record of excellent collaboration across multiple disciplines, while achieving success with large research teams like the Collaborative Pediatric Critical Care Research Network (CPCCRN). He played a leadership roles in CANDLE (Condition Affecting Neuro-Development & Learning in Early infancy) and other activities of the Urban Child Institute and UT Neuroscience Institute. More recently, he led the NeoOpioid Consortium funded by the European Commission, which collected data from 243 NICUs in 18 European countries.
Assessment of Pain in Newborns and Older Infants (Infant Pain Assessment Study =
Pain assessments in non-verbal, critically ill infants represent an important clinical
challenge. Older children or adults can easily express their pain, but infants lack that
capability. They frequently experience repetitive acute pain during routine ICU care, but
their analgesic management flounders on the horns of a dilemma: (a) failure to treat infant
pain leads to immediate clinical instability and potentially long-term physical, behavioral,
and cognitive sequelae, vs. (b) strong analgesics may increase risks for medical
complications and/or impaired brain growth. Bedside nurses currently assess pain using pain
scores, before taking action to ameliorate pain. Pain scores increase nursing workload and
provide subjective assessments, rather than objective data for evaluating infant pain.
Consequently, infants exposed to skin-breaking procedures, surgery, or other painful
conditions often receive variable and inconsistent pain management in the ICU. The
investigators aim to develop a multimodal pain assessment system, using sensor fusion and
novel machine learning algorithms to provide an objective measure of pain that is
context-dependent and rater-independent. This will enhance the quality of pain management in
ICUs and allow continuous pain monitoring in real-time.
Stanford is currently not accepting patients for this trial.
For more information, please contact Spectrum Child Health, 650-724-1175.
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