Diplom, Eberhard Karls Universitat Tubingen (2008)
Doctor of Philosophy, Eberhard Karls Universitat Tubingen (2015)
James Ferrell, Postdoctoral Faculty Sponsor
Cell-cycle phosphorylation is temporally ordered, at least in part, through the sequential expression of different cyclins. Recent studies by Swaffer et al. (2016) and Godfrey et al. (2017) show that intrinsic properties of the substrate proteins contribute as well: good kinase substrates tend to be phosphorylated early, and good phosphatase substrates tend to be phosphorylated late.
View details for DOI 10.1016/j.molcel.2017.01.025
View details for PubMedID 28157499
The separation of chromosomes in anaphase is a precarious step in the cell cycle. The separation is irreversible, and any error can lead to cell death or genetic instability. Chromosome separation is controlled by the protease separase. Here we discuss recent work that has revealed additional layers of separase regulation and has deepened our understanding of how separase activation is coordinated with other events of mitotic exit.
View details for DOI 10.1016/j.tcb.2016.07.008
View details for Web of Science ID 000392352800004
View details for PubMedID 27567180