Support teaching, research, and patient care.
Int'l School of Biological Magnetic Resonance (ISBMR)
Graduate Students & Postdoctoral Fellows
postdoctoral researchers and graduate students
Graduate Students and Postdoctoral Scholars
NMR; Biophysics; Structural Biology; Biochemistry; X-ray Crystallography; Computational Biology
NSF; EMFCSC; Russian Academy of Sciences
NATO; NSF; EMFCSC; Russian Academy of Sciences
Graduate Students and Postdoctoral Fellows
NMR spectroscopy; X-ray diffraction; Ribosome structure; Single-molecule methods
NATO, NSF, Russian Academy of Sciences
NMR Principles; X-ray diffraction; Single-molecule analysis of biomolecules; Protein folding
Grad Students and Postdoctoral Fellows
NMR Spectroscopy; X-ray Crystallography; Molecular Dynamics; Single-molecule fluorescence
X-ray Crystallography; High Resolution NMR; Molecular Dynamics
The Puglisi group investigates the role of RNA in cellular processes and disease. Our goal is to understand RNA function in terms of molecular structure and dynamics using a variety of biophysical and biological tools. We use nuclear magnetic resonance (NMR) spectroscopy to determine structures of biological molecules, and integrate structural understanding into further mechanistic and functional studies. We investigate dynamics using single-molecule approaches. Our goal is a unified picture of structure, dynamics and function. We are currently focused on the mechanism and regulation of translation, and the role of RNA in viral infections. A long-term goal is to target processes involving RNA with novel therapeutic strategies.