Bio

Honors & Awards


  • Future of Science Fund Scholarship, Keystone Symposia (2012)
  • Diversifying Academia, Recruiting Excellence (DARE) Graduate Fellowship, Stanford University (2010-2012)
  • Keynote Speaker, Bakersfield Community College MESA Program (2010)
  • Travel Grant, Ford Fellows Leadership Conference (2007)
  • Gates Millennium Graduate Fellowship, Gates Foundation (2006-2010)

Professional Education


  • Doctor of Philosophy, Stanford University, MI-PHD (2013)
  • Bachelor of Science, University of California Berkeley, Chemical Biology (2006)

Stanford Advisors


Publications

Journal Articles


  • The NeST Long ncRNA Controls Microbial Susceptibility and Epigenetic Activation of the Interferon-gamma Locus CELL Gomez, J. A., Wapinski, O. L., Yang, Y. W., Bureau, J., Gopinath, S., Monack, D. M., Chang, H. Y., Brahic, M., Kirkegaard, K. 2013; 152 (4): 743-754

    Abstract

    Long noncoding RNAs (lncRNAs) are increasingly appreciated as regulators of cell-specific gene expression. Here, an enhancer-like lncRNA termed NeST (nettoie Salmonella pas Theiler's [cleanup Salmonella not Theiler's]) is shown to be causal for all phenotypes conferred by murine viral susceptibility locus Tmevp3. This locus was defined by crosses between SJL/J and B10.S mice and contains several candidate genes, including NeST. The SJL/J-derived locus confers higher lncRNA expression, increased interferon-? (IFN-?) abundance in activated CD8(+) T cells, increased Theiler's virus persistence, and decreased Salmonella enterica pathogenesis. Transgenic expression of NeST lncRNA alone was sufficient to confer all phenotypes of the SJL/J locus. NeST RNA was found to bind WDR5, a component of the histone H3 lysine 4 methyltransferase complex, and to alter histone 3 methylation at the IFN-? locus. Thus, this lncRNA regulates epigenetic marking of IFN-?-encoding chromatin, expression of IFN-?, and susceptibility to a viral and a bacterial pathogen.

    View details for DOI 10.1016/j.cell.2013.01.015

    View details for Web of Science ID 000314945600010

    View details for PubMedID 23415224

Stanford Medicine Resources: