Clinical Focus

  • Neonatology
  • Clinical Informatics

Academic Appointments

Administrative Appointments

  • Program Director, Clinical Informatics Fellowship, Stanford University School of Medicine (2015 - Present)
  • Medical Director, Clinical Informatics Innovation, Lucile Packard Children's Hospital Stanford (2016 - Present)
  • Medical Director, Clinical Informatics Analytics, Lucile Packard Children's Hospital Stanford (2012 - 2015)
  • Associate Program Director, Clinical Informatics Fellowship, Stanford University School of Medicine (2014 - 2015)
  • Associate Medical Director, Clinical Informatics, Lucile Packard Children's Hospital (2009 - 2009)
  • Physician Lead, Neonatal Informatics, Lucile Packard Children's Hospital (2008 - 2008)

Honors & Awards

  • Pediatric Clerkship Honor Roll for Teaching Excellence, Stanford University School of Medicine (2006, 2008)
  • First Place, Innovate 4 Healthcare Challenge, Johnson & Johnson; University of Maryland School of Business (2012)
  • Award of Excellence for Information Optimization, Hewlett Packard/Autonomy (2014)

Boards, Advisory Committees, Professional Organizations

  • Member, Alpha Omega Alpha Medical Honor Society (2004 - Present)
  • Member, Gold Humanism Honor Society (2004 - Present)

Professional Education

  • Board Certification: Neonatal-Perinatal Medicine, American Board of Pediatrics (2014)
  • Board Certification: Clinical Informatics, American Board of Preventive Medicine (2014)
  • Board Certification: Pediatrics, American Board of Pediatrics (2008)
  • MS, Biomedical Informatics, Stanford University School of Medicine (2012)
  • Fellowship:Lucile Packard Children's Hospital (2012) CA
  • Residency:Lucile Packard Children's Hospital (2008) CA
  • Medical Education:University of Florida (2005) FL
  • BS, Biology, Chemistry, Davidson College (2000)

Research & Scholarship

Current Research and Scholarly Interests

I'm a Clinical Associate Professor of Pediatrics in the Division of Neonatal and Developmental Medicine at Stanford University. In addition to my clinical role is in newborn intensive care, I have an administrative appointment as Medical Director of Clinical Informatics at Stanford Children's Health. I completed a Master's in Biomedical Informatics at Stanford, became board certified in Clinical Informatics with the inaugural class in 2013, and serve as Program Director for the Stanford Clinical Informatics Fellowship program.

My clinical informatics efforts focus on optimizing electronic workflows for neonatology providers, and my academic interests include interventional informatics to achieve examples of a learning healthcare system. I also enjoy applying technologies such as text and predictive analytics to hospital data to enhance the quality and safety of healthcare.

I attended Davidson College and graduated cum laude from the University of Florida College of Medicine, then completed clinical training in pediatrics and neonatal-perinatal medicine at Lucile Packard Children's Hospital Stanford. During residency and fellowship my scholarly work was optimizing EMRs for neonatal care, and my Master's research was mining clinical data to predict the development of disease.


  • Clinical Informatics Fellowship, Stanford University Medical Center


    Palo Alto, CA


    • Christopher Longhurst, Clinical Associate Professor, School of Medicine
    • Natalie Pageler, Clinical Associate Professor, School of Medicine
    • Christopher Sharp, Clinical Associate Professor, School of Medicine
    • Pravene Nath, Clinical Assistant Professor, School of Medicine
    • Todd Ferris, Associate CIO, SoM - Information Resources & Technology, School of Medicine

    For More Information:


All Publications

  • Neonatal Informatics: Transforming Neonatal Care Through Translational Bioinformatics. NeoReviews Palma, J. P., Benitz, W. E., Tarczy-Hornoch, P., Butte, A. J., Longhurst, C. A. 2012; 13 (5): e281-e284


    The future of neonatal informatics will be driven by the availability of increasingly vast amounts of clinical and genetic data. The field of translational bioinformatics is concerned with linking and learning from these data and applying new findings to clinical care to transform the data into proactive, predictive, preventive, and participatory health. As a result of advances in translational informatics, the care of neonates will become more data driven, evidence based, and personalized.

    View details for PubMedID 22924023

  • Impact of electronic medical record integration of a handoff tool on sign-out in a newborn intensive care unit JOURNAL OF PERINATOLOGY Palma, J. P., Sharek, P. J., Longhurst, C. A. 2011; 31 (5): 311-317


    Objective:To evaluate the impact of integrating a handoff tool into the electronic medical record (EMR) on sign-out accuracy, satisfaction and workflow in a neonatal intensive care unit (NICU).Study Design:Prospective surveys of neonatal care providers in an academic children's hospital 1 month before and 6 months following EMR integration of a standalone Microsoft Access neonatal handoff tool.Result:Providers perceived sign-out information to be somewhat or very accurate at a rate of 78% with the standalone handoff tool and 91% with the EMR-integrated tool (P < 0.01). Before integration of neonatal sign-out into the EMR, 35% of providers were satisfied with the process of updating sign-out information and 71% were satisfied with the printed sign-out document; following EMR integration, 92% of providers were satisfied with the process of updating sign-out information (P < 0.01) and 98% were satisfied with the printed sign-out document (P<0.01). Neonatal care providers reported spending a median of 11 to 15 min/day updating the standalone sign-out and 16 to 20 min/day updating the EMR-integrated sign-out (P = 0.026). The median percentage of total sign-out preparation time dedicated to transcribing information from the EMR was 25 to 49% before and <25% after EMR integration of the handoff tool (P < 0.01).Conclusion:Integration of a NICU-specific handoff tool into an EMR resulted in improvements in perceived sign-out accuracy, provider satisfaction and at least one aspect of workflow.

    View details for DOI 10.1038/jp.2010.202

    View details for Web of Science ID 000289982300003

    View details for PubMedID 21273990

  • Early experiences of accredited clinical informatics fellowships. Journal of the American Medical Informatics Association Longhurst, C. A., Pageler, N. M., Palma, J. P., Finnell, J. T., Levy, B. P., Yackel, T. R., Mohan, V., Hersh, W. R. 2016; 23 (4): 829-834


    Since the launch of the clinical informatics subspecialty for physicians in 2013, over 1100 physicians have used the practice and education pathways to become board-certified in clinical informatics. Starting in 2018, only physicians who have completed a 2-year clinical informatics fellowship program accredited by the Accreditation Council on Graduate Medical Education will be eligible to take the board exam. The purpose of this viewpoint piece is to describe the collective experience of the first four programs accredited by the Accreditation Council on Graduate Medical Education and to share lessons learned in developing new fellowship programs in this novel medical subspecialty.

    View details for DOI 10.1093/jamia/ocv209

    View details for PubMedID 27206458

  • Development of a Web - Based Decision Support Tool to Operationalize and Optimize Management of Hyperbilirubinemia in Preterm Infants CLINICS IN PERINATOLOGY Palma, J. P., Arain, Y. H. 2016; 43 (2): 375-?


    Premie BiliRecs is a novel electronic clinical decision support tool for the management of hyperbilirubinemia in moderately preterm infants less than 35 weeks gestational age. It serves to operationalize and automate current expert consensus-based guidelines, and to aid in the generation of new practice-based evidence to inform future guidelines.

    View details for DOI 10.1016/j.clp.2016.01.009

    View details for Web of Science ID 000378367300014

    View details for PubMedID 27235214

  • Failed endotracheal intubation and adverse outcomes among extremely low birth weight infants. Journal of perinatology Wallenstein, M. B., Birnie, K. L., Arain, Y. H., Yang, W., Yamada, N. K., Huffman, L. C., Palma, J. P., Chock, V. Y., Shaw, G. M., Stevenson, D. K. 2016; 36 (2): 112-115


    To quantify the importance of successful endotracheal intubation on the first attempt among extremely low birth weight (ELBW) infants who require resuscitation after delivery.A retrospective chart review was conducted for all ELBW infants ⩽1000 g born between January 2007 and May 2014 at a level IV neonatal intensive care unit. Infants were included if intubation was attempted during the first 5 min of life or if intubation was attempted during the first 10 min of life with heart rate <100. The primary outcome was death or neurodevelopmental impairment. The association between successful intubation on the first attempt and the primary outcome was assessed using multivariable logistic regression with adjustment for birth weight, gestational age, gender and antenatal steroids.The study sample included 88 ELBW infants. Forty percent were intubated on the first attempt and 60% required multiple intubation attempts. Death or neurodevelopmental impairment occurred in 29% of infants intubated on the first attempt, compared with 53% of infants that required multiple attempts, adjusted odds ratio 0.4 (95% confidence interval 0.1 to 1.0), P<0.05.Successful intubation on the first attempt is associated with improved neurodevelopmental outcomes among ELBW infants. This study confirms the importance of rapid establishment of a stable airway in ELBW infants requiring resuscitation after birth and has implications for personnel selection and role assignment in the delivery room.Journal of Perinatology advance online publication, 5 November 2015; doi:10.1038/jp.2015.158.

    View details for DOI 10.1038/jp.2015.158

    View details for PubMedID 26540244

  • Case 1: Lactic Acidosis and Respiratory Distress in a 10-Day-Old Infant. NeoReviews Wallenstein, M. B., Olson, K., Peng, D. M., Stevenson, D. K., Shaw, G. M., Palma, J. P., Bain, L. C. 2015; 16 (7): e431-e433

    View details for PubMedID 26236172

  • An Exponential Increase in Regional Health Information Exchange With Collaborative Policies and Technologies. Studies in health technology and informatics Downing, N. L., Lane, S., Eisenberg, M., Sharp, C., Palma, J., Longhurst, C. 2015; 216: 931-?


    In the United States, the ability to securely exchange health information between organization has been limited by technical interoperability, patient identity matching, and variable institutional policies. Here, we examine the regional experience in a national health information exchange network by examining clinical data sharing between eleven Northern California organizations using the same health information exchange (HIE) platform between 2013-2014. We identify key policies and technologies that have led to a dramatic increase in health information exchange.

    View details for PubMedID 26262233

  • Implementation of Data Drive Heart Rate and Respiratory Rate parameters on a Pediatric Acute Care Unit. Studies in health technology and informatics Goel, V., Poole, S., Kipps, A., Palma, J., Platchek, T., Pageler, N., Longhurst, C., Sharek, P. 2015; 216: 918-?


    The majority of hospital physiologic monitor alarms are not clinically actionable and contribute to alarm fatigue. In 2014, The Joint Commission declared alarm safety as a National Patient Safety Goal and urged prompt action by hospitals to mitigate the issue [1]. It has been demonstrated that vital signs in hospitalized children are quite different from currently accepted reference ranges [2]. Implementation of data-driven, age stratified vital sign parameters (Table 1) for alarms in this patient population could reduce alarm frequency.

    View details for PubMedID 26262220

  • Red Blood Cell Transfusion Is Not Associated with Necrotizing Enterocolitis: A Review of Consecutive Transfusions in a Tertiary Neonatal Intensive Care Unit JOURNAL OF PEDIATRICS Wallenstein, M. B., Arain, Y. H., Birnie, K. L., Andrews, J., Palma, J. P., Benitz, W. E., Chock, V. Y. 2014; 165 (4): 678-682
  • Pulmonary hypertensive crisis following ethanol sclerotherapy for a complex vascular malformation JOURNAL OF PERINATOLOGY Cordero-Schmidt, G., Wallenstein, M. B., Ozen, M., Shah, N. A., Jackson, E., Hovsepians, D. M., Palma, J. P. 2014; 34 (9): 713-715


    Anhydrous ethanol is a commonly used sclerotic agent for treating vascular malformations. We describe the case of a full-term 15-day-old female with a complex venolymphatic malformation involving the face and orbit. During treatment of the lesion with ethanol sclerotherapy, she suffered acute pulmonary hypertensive crisis. We discuss the pathophysiology of pulmonary hypertension related to ethanol sclerotherapy, and propose that hemolysis plays a significant role. Recommendations for evaluation, monitoring and management of this complication are also discussed.

    View details for DOI 10.1038/jp.2014.88

    View details for Web of Science ID 000341403600014

    View details for PubMedID 25179381

  • Anti-Ge3 causes late-onset hemolytic disease of the newborn: the fourth case in three Hispanic families TRANSFUSION Pate, L. L., Myers, J. C., Palma, J. P., Viele, M., Galel, S. A., Ferrer, Z., Gonzalez, C. L., Benitz, W. E., Garratty, G., Fontaine, M. J. 2013; 53 (10): 2152-2157


    BACKGROUND: The Gerbich (Ge) blood group system consists of 11 antigens carried on red blood cell (RBC) membrane glycophorins C and D; of these, Ge:3 antigen is of high prevalence, and the anti-Ge3 is found to be clinically significant. CASE REPORT: A 34-week neonate born to a Hispanic mother with anti-Ge3 developed late-onset hemolysis with hyperbilirubinemia and was successfully treated with transfusions from her mother. Relevant clinical findings and laboratory results for this case are summarized and compared to three other previously reported cases; all babies were born from a mother of Hispanic ethnicity. CONCLUSION: Hemolytic disease of the fetus and new born associated with anti-Ge3 is rare but should be considered when working up a broadly reactive RBC antibody screen in women of Hispanic ethnicity. Early identification of pregnant women with anti-Ge3 is recommended for prenatal transfusion planning and close monitoring of the newborn infant for evidence of late-onset anemia.

    View details for DOI 10.1111/trf.12027

    View details for Web of Science ID 000325374300011

  • Using an Evidence-Based Approach to EMR Implementation to Optimize Outcomes and Avoid Unintended Consequences. Journal of healthcare information management : JHIM Longhurst, C. A., Palma, J. P., Grisim, L. M., Widen, E., Chan, M., Sharek, P. J. 2013; 27 (3): 79-83


    Implementation of an electronic medical record (EMR) with computerized physician order entry (CPOE) can provide an important foundation for preventing harm and improving outcomes. Incentivized by the recent economic stimulus initiative, healthcare systems are implementing vendor-based EMR systems at an unprecedented rate. Accumulating evidence suggests that local implementation decisions, rather than the specific EMR product or technology selected, are the primary drivers of the quality improvement performance of these systems. However, limited attention has been paid to effective approaches to EMR implementation. In this case report, we outline the evidence-based approach we used to make EMR implementation decisions in a pragmatic structure intended for replication at other sites.

    View details for PubMedID 24771994

  • Immunization registries in the EMR Era. Online journal of public health informatics Stevens, L. A., Palma, J. P., Pandher, K. K., Longhurst, C. A. 2013; 5 (2): 211-?


    The CDC established a national objective to create population-based tracking of immunizations through regional and statewide registries nearly 2 decades ago, and these registries have increased coverage rates and reduced duplicate immunizations. With increased adoption of commercial electronic medical records (EMR), some institutions have used unidirectional links to send immunization data to designated registries. However, access to these registries within a vendor EMR has not been previously reported.To develop a visually integrated interface between an EMR and a statewide immunization registry at a previously non-reporting hospital, and to assess subsequent changes in provider use and satisfaction.A group of healthcare providers were surveyed before and after implementation of the new interface. The surveys addressed access of the California Immunization Registry (CAIR), and satisfaction with the availability of immunization information. Information Technology (IT) teams developed a "smart-link" within the electronic patient chart that provides a single-click interface for visual integration of data within the CAIR database.Use of the tool has increased in the months since its initiation, and over 20,000 new immunizations have been exported successfully to CAIR since the hospital began sharing data with the registry. Survey data suggest that providers find this tool improves workflow and overall satisfaction with availability of immunization data. (p=0.009).Visual integration of external registries into a vendor EMR system is feasible and improves provider satisfaction and registry reporting.

    View details for DOI 10.5210/ojphi.v5i2.4696

    View details for PubMedID 23923096

  • Impact of an EMR-Based Daily Patient Update Letter on Communication and Parent Engagement in a Neonatal Intensive Care Unit. Journal of participatory medicine Palma, J. P., Keller, H., Godin, M., Wayman, K., Cohen, R. S., Rhine, W. D., Longhurst, C. A. 2012; 4


    To evaluate the impact of using electronic medical record (EMR) data in the form of a daily patient update letter on communication and parent engagement in a level II neonatal intensive care unit (NICU).Parents of babies in a level II NICU were surveyed before and after the introduction of an EMR-generated daily patient update letter, Your Baby's Daily Update (YBDU).Following the introduction of the EMR-generated daily patient update letter, 89% of families reported using YBDU as an information source; 83% of these families found it "very useful", and 96% of them responded that they "always" liked receiving it. Rates of receiving information from the attending physician were not statistically significantly different pre- and post-implementation, 81% and 78%, respectively (p = 1). Though there was no statistically significant improvement in parents' knowledge of individual items regarding the care of their babies, a trend towards statistical significance existed for several items (p <.1), and parents reported feeling more competent to manage information related to the health status of their babies (p =.039).Implementation of an EMR-generated daily patient update letter is feasible, resulted in a trend towards improved communication, and improved at least one aspect of parent engagement-perceived competence to manage information in the NICU.

    View details for PubMedID 23730532

  • Neonatal Informatics: Optimizing Clinical Data Entry and Display. NeoReviews Palma, J. P., Brown, P. J., Lehmann, C. U., Longhurst, C. A. 2012; 13 (2): 81-85


    Displaying the vast amount of clinical data that exist in electronic medical records without causing information overload or interfering with provider thought processes is a challenge. To support the transformation of data into information and knowledge, effective electronic displays must be flexible and guide physicians' thought processes. Applying research from cognitive science and human factors engineering offers promise in improving the electronic display of clinical information. OBJECTIVES: After completing this article, readers should be able to: Appreciate the importance of supporting provider thought processes during both data entry and data review.Recognize that information does not need to be displayed and reviewed in the same way the data are entered.

    View details for PubMedID 22557935

  • Neonatal Informatics: Computerized Physician Order Entry. NeoReviews Palma, J. P., Sharek, P. J., Classen, D. C., Longhurst, C. A. 2011; 12: 393-396


    Computerized physician order entry (CPOE) is the feature of electronic medical record (EMR) implementation that arguably offers the greatest quality and patient safety benefits. The gains are potentially greater for critically ill neonates, but the effect of CPOE on quality and safety is dependent upon local implementation decisions. OBJECTIVES: After completing this article, readers should be able to: Define the basic aspects of CPOE and clinical decision support (CDS) systems.Describe the potential benefits of implementing CPOE associated with CDS in a neonatal intensive care unit (NICU).

    View details for PubMedID 21804768

  • Neonatal Informatics: Information Technology to Support Handoffs in Neonatal Care. NeoReviews Palma, J. P., Van Eaton, E. G., Longhurst, C. A. 2011; 2011 (12)


    Communication failures during physician handoffs represent a significant source of preventable adverse events. Computerized sign-out tools linked to hospital electronic medical record systems and customized for neonatal care can facilitate standardization of the handoff process and access to clinical information, thereby improving communication and reducing adverse events. It is important to note, however, that adoption of technological tools alone is not sufficient to remedy flawed communication processes. OBJECTIVES: After completing this article, readers should be able to: Identify key elements of a computerized sign-out tool.Describe how an electronic tool might be customized for neonatal care.Appreciate that technological tools are only one component of the handoff process they are designed to facilitate.

    View details for PubMedID 22199463