Bio

Honors & Awards


  • Young Investigator Award, European Society of Magnetic Resonance in Medicine and Biology (ESMRMB) (2017)
  • Student stipend, International Society of Magnetic Resonance in Medicine (ISMRM) (2016-2017)
  • Student stipend, International Society of Magnetic Resonance in Medicine British Chapter (ISMRM-BC) (2016)

Professional Education


  • PhD, University of Cambridge, Radiology (2017)
  • BSc, Fudan University, Physics (2013)

Research & Scholarship

Current Research and Scholarly Interests


Advanced sequence development, image processing, and their clinical application in pediatric and body MRI

Publications

All Publications


  • A Comparison of Black-blood T2 Mapping Sequences for Carotid Vessel Wall Imaging at 3T: An Assessment of Accuracy and Repeatability Magnetic Resonance in Medical Sciences Yuan, J., Patterson, A., Ruetten, P., Reid, S., Gillard, J., Graves, M. 2018
  • Neovascularization in Vertebral Artery Atheroma—A Dynamic Contrast-Enhanced Magnetic Resonance Imaging-Based Comparative Study in Patients with Symptomatic and Asymptomatic Carotid Artery Disease Journal of Stroke and Cerebrovascular Diseases Usman, A., Yuan, J., Patterson, A., Graves, M., Varty, K., Sadat, U., Gillard, J. 2018
  • The development and optimisation of 3D black-blood R2* mapping of the carotid artery wall Magnetic Resonance Imaging Yuan, J., Graves, M., Patterson, A., Priest, A., Ruetten, P., Usman, A., Gillard, J. 2017; 44: 104-110

    Abstract

    To develop and optimise a 3D black-blood R2* mapping sequence for imaging the carotid artery wall, using optimal blood suppression and k-space view ordering.Two different blood suppression preparation methods were used; Delay Alternating with Nutation for Tailored Excitation (DANTE) and improved Motion Sensitive Driven Equilibrium (iMSDE) were each combined with a three-dimensional (3D) multi-echo Fast Spoiled GRadient echo (ME-FSPGR) readout. Three different k-space view-order designs: Radial Fan-beam Encoding Ordering (RFEO), Distance-Determined Encoding Ordering (DDEO) and Centric Phase Encoding Order (CPEO) were investigated. The sequences were evaluated through Bloch simulation and in a cohort of twenty volunteers. The vessel wall Signal-to-Noise Ratio (SNR), Contrast-to-Noise Ratio (CNR) and R2*, and the sternocleidomastoid muscle R2* were measured and compared. Different numbers of acquisitions-per-shot (APS) were evaluated to further optimise the effectiveness of blood suppression.All sequences resulted in comparable R2* measurements to a conventional, i.e. non-blood suppressed sequence in the sternocleidomastoid muscle of the volunteers. Both Bloch simulations and volunteer data showed that DANTE has a higher signal intensity and results in a higher image SNR than iMSDE. Blood suppression efficiency was not significantly different when using different k-space view orders. Smaller APS achieved better blood suppression.The use of blood-suppression preparation methods does not affect the measurement of R2*. DANTE prepared ME-FSPGR sequence with a small number of acquisitions-per-shot can provide high quality black-blood R2* measurements of the carotid vessel wall.

    View details for DOI 10.1016/j.mri.2017.08.006

  • Three-dimensional black-blood multi-contrast carotid imaging using compressed sensing: a repeatability study Magnetic Resonance Materials in Physics, Biology and Medicine Yuan, J., Usman, A., Reid, S., King, K., Patterson, A., Gillard, J., Graves, M. 2017: 1-8

    Abstract

    The purpose of this work is to evaluate the repeatability of a compressed sensing (CS) accelerated multi-contrast carotid protocol at 3 T.Twelve volunteers and eight patients with carotid disease were scanned on a 3 T MRI scanner using a CS accelerated 3-D black-blood multi-contrast protocol which comprises T 1w, T 2w and PDw without CS, and with a CS factor of 1.5 and 2.0. The volunteers were scanned twice, the lumen/wall area and wall thickness were measured for each scan. Eight patients were scanned once, the inter/intra-observer reproducibility of the measurements was calculated.In the repeated volunteer scans, the interclass correlation coefficient (ICC) for the wall area measurement using a CS factor of 1.5 in PDw, T 1w and T 2w were 0.95, 0.81, and 0.97, respectively. The ICC for lumen area measurement using a CS factor of 1.5 in PDw, T 1w and T 2w were 0.96, 0.92, and 0.96, respectively. In patients, the ICC for inter/intra-observer measurements of lumen/wall area, and wall thickness were all above 0.81 in all sequences.The results show a CS accelerated 3-D black-blood multi-contrast protocol is a robust and reproducible method for carotid imaging. Future protocol design could use CS to reduce the scanning time.

    View details for DOI 10.1007/s10334-017-0640-1

    View details for PubMedCentralID PMC5813054

  • Three-dimensional black-blood T2 mapping with compressed sensing and data-driven parallel imaging in the carotid artery Magnetic Resonance Imaging Yuan, J., Usman, A., Reid, S., King, K., Patterson, A., Gillard, J., Graves, M. 2017; 37: 62-69
  • Relationship between carotid plaque surface morphology and perfusion: a 3D DCE-MRI study Magnetic Resonance Materials in Physics, Biology and Medicine Yuan, J., Makris, G., Patterson, A., Usman, A., Das, T., Priest, A., Teng, Z., Hilborne, S., Prudencio, D., Gillard, J., Graves, M. 2017: 1-9
  • Imaging carotid atherosclerosis plaque ulceration: comparison of advanced imaging modalities and recent developments American Journal of Neuroradiology Yuan, J., Usman, A., Das, T., Patterson, A., Gillard, J., Graves, M. 2017; 38 (4): 664-671

    View details for DOI 10.3174/ajnr.A5026

  • The influence of constitutive law choice used to characterise atherosclerotic tissue material properties on computing stress values in human carotid plaques Journal of biomechanics Teng, Z., Yuan, J., Feng, J., Zhang, Y., Brown, A., Wang, S., Lu, Q., Gillard, J. 2015; 48 (14): 3912-3921
  • Influence of material property variability on the mechanical behaviour of carotid atherosclerotic plaques: A 3D fluid‐structure interaction analysis International journal for numerical methods in biomedical engineering Yuan, J., Teng, Z., Feng, J., Zhang, Y., Brown, A., Gillard, J., Jing, Z., Lu, Q. 2015; 31 (8)

    View details for DOI 10.1002/cnm.2722

  • Material properties of components in human carotid atherosclerotic plaques: a uniaxial extension study Acta biomaterialia Teng, Z., Zhang, Y., Huang, Y., Feng, J., Yuan, J., Lu, Q., Sutcliffe, M., Brown, A., Jing, Z., Gillard, J. 2014; 10 (12): 5055-5063
  • Optimization of improved motion-sensitized driven-equilibrium (iMSDE) blood suppression for carotid artery wall imaging Journal of Cardiovascular Magnetic Resonance Zhu, C., Graves, M., Yuan, J., Sadat, U., Gillard, J., Patterson, A. 2014; 16 (1): 61