Cutaneous Metastatic Rectal Carcinoma Masquerading as Herpes Zoster
SOUTHERN MEDICAL JOURNAL
Eichinger, J., George, B., Myhand, R.
2011; 104 (3): 233-235
Abstract
A 78-year-old female with locally recurrent rectal carcinoma and hepatic metastases presented with new skin lesions. She had multiple painful skin lesions over her groin area initially treated as contact dermatitis. The lesions continued to spread to include the lower abdomen and developed a zosteriform appearance. She was referred to dermatology, where shave biopsies revealed metastatic rectal carcinoma. This case is unique as the patient had rapidly growing zosteriform cutaneous metastases from rectal carcinoma, which has rarely been reported. Physicians providing care to patients with a history of cancer should maintain a high clinical suspicion for cutaneous metastases in patients with new or evolving skin conditions.
View details for DOI 10.1097/SMJ.0b013e31820bfd04
View details for Web of Science ID 000287473400015
View details for PubMedID 21297531
Abstract
A 65-year-old female patient with glioblastoma multiforme (GBM) developed aplastic anemia following treatment with temozolomide. Following her diagnosis of GBM, the patient received standard treatment with surgery, concomitant radiation therapy and temozolomide followed by adjuvant temozolomide. On day 14 of her adjuvant treatment, she developed profound fatigue and spontaneous bruising and was noted to be severely pancytopenic. After an extensive workup, she was found to have aplastic anemia on bone marrow bipsy. Further studies did not reveal any other etiology and she was not on any other medications known to cause aplastic anemia. There have been two previously published cases involving aplastic anemia due to temozolomide. This case represents a rare but potentially fatal toxicity from temozolomide.
View details for Web of Science ID 000269957800026
View details for PubMedID 19668033
