Current Research and Scholarly Interests
My research is focused on developing magnetic resonance imaging (MRI) methods that probe brain tissue microstructure. This requires new MRI contrast mechanisms, strategic encoding and reconstruction schemes, physiological monitoring, brain tissue modeling and validation. Applications of these methods include neuronavigation, neurosurgical planning and the development of improved biomarkers for brain development, degeneration, disease and injury. Active projects include comparisons of MRI with CLARITY 3D histology, development of mixed-reality neuronavigation, leveraging 7T MRI for predicting healthy versus pathological aging, developing high-resolution diffusion MRI methods that can map the fiber patterns of the cerebral cortex, diffusion tractography-based targeting for deep brain stimulation and MRI-guided focused ultrasound and the development of double diffusion encoding and q-space trajectory imaging for improved microstructural sensitivity and specificity.