Bio

Clinical Focus


  • Anesthesia
  • Critical Care

Academic Appointments


Honors & Awards


  • Rathmann Fellow, E4C Medical Education Fellowship in Patient Centered Care. (July 2014 - June 2015)

Professional Education


  • Residency:Stanford University Anesthesiology Residency (2012) CA
  • Internship:Kaiser Permanente Oakland Internal Medicine Residency (2009) CA
  • Medical Education:Stanford University School of Medicine Registrar (2008) CA
  • Fellowship:Stanford University Critical Care Medicine Fellowship (2013) CA
  • Board Certification: Critical Care Medicine, American Board of Anesthesiology (2013)
  • Board Certification: Anesthesia, American Board of Anesthesiology (2013)

Research & Scholarship

Clinical Trials


  • Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock Recruiting

    To compare the safety and efficacy of the PMX cartridge based on mortality at 28-days in subjects with septic shock who have high levels of endotoxin and are treated with standard medical care plus use of the PMX cartridge, versus subjects who receive standard medical care alone.

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  • Study of a Candidate Clostridium Difficile Toxoid Vaccine in Subjects at Risk for C. Difficile Infection Recruiting

    The aim of this study is to evaluate the efficacy of the candidate Clostridium difficile vaccine to prevent primary symptomatic C. difficile infection (CDI) in subjects a risk for CDI where there is a substantial unmet medical need. Primary objective: - To assess the efficacy of the C. difficile vaccine in preventing the onset of symptomatic primary CDI confirmed by polymerase chain reaction (PCR) in adult subjects aged ≥ 50 years who are at risk for CDI and have received at least 1 injection. Secondary Objectives: Efficacy: - To assess prevention of symptomatic PCR-confirmed primary CDI cases after 3 injections administered at 0, 7, and 30 days - To assess prevention of symptomatic PCR-confirmed primary CDI cases after completion of at least 2 injections. Immunogenicity: - To describe the immunogenicity to toxin A and toxin B in the subset of subjects at specific time points. Safety: - To describe the safety profile of all subjects who receive at least 1 injection.

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Teaching

Graduate and Fellowship Programs


  • Critical Care Medicine (Fellowship Program)

Publications

All Publications


  • Alterations in Spanish Language Interpretation During Pediatric Critical Care Family Meetings CRITICAL CARE MEDICINE Sinow, C. S., Corso, I., Lorenzo, J., Lawrence, K. A., Magnus, D. C., Van Cleave, A. C. 2017; 45 (11): 1915–21

    Abstract

    To characterize alterations in Spanish language medical interpretation during pediatric critical care family meetings.Descriptive, observational study using verbatim transcripts of nine PICU family meetings conducted with in-person, hospital-employed interpreters.A single, university-based, tertiary children's hospital.Medical staff, family members, ancillary staff, and interpreters.None.Interpreted speech was compared with original clinician or family speech using the qualitative research methods of directed content analysis and thematic analysis. Alterations occurred in 56% of interpreted utterances and included additions, omissions, substitutions, editorializations, answering for the patient/clinician, confessions, and patient advocacy. Longer utterances were associated with more alterations.To minimize interpreter alterations during family meetings, physicians should speak in short utterances (fewer than 20 words) and ask interpreters to interrupt in order to facilitate accurate interpretation. Because alterations occur, physicians may also regularly attempt to assess the family's understanding.

    View details for DOI 10.1097/CCM.0000000000002650

    View details for Web of Science ID 000417107000053

    View details for PubMedID 28777199

  • Examining Health Care Costs: Opportunities to Provide Value in the Intensive Care Unit. Anesthesiology clinics Chang, B., Lorenzo, J., Macario, A. 2015; 33 (4): 753-770

    Abstract

    As health care costs threaten the economic stability of American society, increasing pressures to focus on value-based health care have led to the development of protocols for fast-track cardiac surgery and for delirium management. Critical care services can be led by anesthesiologists with the goal of improving ICU outcomes and at the same time decreasing the rising cost of ICU medicine.

    View details for DOI 10.1016/j.anclin.2015.07.012

    View details for PubMedID 26610628