Bio

Bio


Idan Steinberg is currently a postdoctoral scholar in the department of radiology at Stanford University. He received his B.Sc. and M.Sc degrees in BME with honors from Tel Aviv University, in 2008 and 2011 respectively. His M.Sc research included: theoretical & experimental developing of magneto-acoustic system for early detection of tumors labeled with magnetic nano-particles as well as biomedical application of hallow core waveguides. During his Ph.D studies, he concentrated in leading the development of an innovative multispectral photo-acoustic technique for evaluation of bone pathologies such as osteoporosis. This new technique can simultaneously measure the bone functionality and biomechanical strength. Idan won the prestigious Clore Scholarship and the Raymond & Beverly Sackler Biophysics Fellowship. He has published a few peer-reviewed papers in high ranking journals, a book chapter and gave several talks in major international conferences. He is the founder & first vice-president of the SPIE student chapter of TAU.

Honors & Awards


  • Contingency Student Travel Grant Award, The International Society for Optical Engineering (SPIE) (2015)
  • Space, Travel Scholarship for an International Conference or Workshops, Israeli Ministry of Science, Technology and Space (2015)
  • Research grants titled: "Optical fiber sensors for ultrasonic detection and measurement", Israeli ministry of science, technology & space \ National program for applied science (2014-2017)
  • Department of Physical Electronics, Best poster award - 1st place, Tel Aviv University (2014)
  • Travel Scholarship for an International Conference or Workshops, Israeli Ministry of Science, Technology and Space (2014)
  • Clore Scholars Program, Sir Charles Clore Israel Foundation (2013-2016)
  • Research Grant title:"Multispectral photoacoustic method for the early detection of Osteoporosis", Israeli ministry of industry, trade & labor \ Kamin program for transnational research (2013-2015)
  • Biophotonics graduate school - Best poster awards - 2nd Place, Biophotonics 13’, Ven Sweden (2013)
  • Contingency Student Travel Grant Award, The International Society for Optical Engineering (SPIE) (2013)
  • SPIE student chapter opening event, Best poster award - 2nd place, Tel Aviv university (2013)
  • Research Grant title:"A photoacoustic spectroscopy method for the early detection of Osteoporosis", The Ela Kodesz Institute for Medical engineering and physical sciences (2012)
  • Biophysics Fellowship, The Raymond & Beverly Sackler Biophysics Prize (2011-2014)
  • Outstanding teaching assistant, Tel Aviv University (2011)
  • Troski Scholarship, Tel Aviv University (2011)
  • Outstanding teaching assistant, Tel Aviv University (2010)
  • Faculty award for outstanding MSc students in engineering, Tel Aviv University (2009)
  • Faculty Scholarship, Tel Aviv University (2008)
  • Faculty award for outstanding undergraduate student, Tel Aviv University (2008)

Professional Education


  • Doctor of Philosophy, Tel-Aviv University (2016)
  • Ph.D, Tel Aviv University, faculty of engineering, Biomedical Engineering (2016)
  • M.Sc (Magna cum Laude), Tel Aviv University, faculty of engineering, Biomedical Engineering (with Business Administration studies) (2010)
  • B.Sc (Magna cum Laude), Biomedical Engineering, Tel Aviv University, faculty of engineering (2008)

Stanford Advisors


Patents


  • Idan Steinberg, Lihi Shiloh , Haniel Gabai, Yacov Botsev, Meir Hahami and Avishay Eyal. "Israel Patent Application No. 62215052 Gated OFDR System", Sep 7, 2015
  • Idan Steinberg, Avishay Eyal and Israel Gannot. "Israel Patent WO 2014118781 A1 Detection, diagnosis and monitoring of osteoporosis by a photo-acoustic method", Jan 31, 2013

Research & Scholarship

Current Research and Scholarly Interests


My current research is focused on developing non-ionizing and low cost medical technologies that reliably detect diagnose and monitor disease progression. I work at the interface of between Photonics, Acoustics, RF, Molecular Imaging, Medical Imaging and Biomedical Signal processing. Equal emphasis is on translating these technologies for pre-clinical and clinical applications in cancer and neurological diseases.

Publications

All Publications


  • Time difference of arrival based cancer tumor localization using magnetic nanoparticles induced acoustic signals Adi, T., Steinberg, I., Gannot, I.

    View details for DOI 10.1557/opl.2012.1533

  • Deep Tissue Imaging: Acoustic and Thermal Wave Propagation and Light Interactions in Tissues Deep Imaging in Tissue and Tissue-Like Media with Linear and Nonlinear Optics Steinberg, I., Shoval, A., Balberg, M., Sheinfeld, A., Gannot, I. CRC Press. 2017
  • Quantitative study of optical and mechanical bone status using multispectral photoacoustics. Journal of biophotonics Steinberg, I., Turko, N., Levi, O., Gannot, I., Eyal, A. 2016; 9 (9): 924-933

    Abstract

    Osteoporosis is a major public health problem worldwide. Here, we present a quantitative multispectral photoacoustic method for the evaluation of bone pathologies which has significant advantages over pure ultrasonic or pure optical methods as it provides both molecular information and bone mechanical status. This is enabled via a simultaneous measurement of the bone's optical properties as well as the speed of sound and ultrasonic attenuation in the bone. To test the method's quantitative predictions, a combined ultrasonic and photoacoustic system was developed. Excitation was performed optically via a portable triple laser-diode system and acoustically via a single element transducer. Additional dual transducers were used for detecting the acoustic waves that were generated by the two modalities. Both temporal and spectral parameters were compared between different excitation wavelengths and measurement modalities. Short photoacoustic excitation wavelengths allowed sensing of the cortical layer while longer wavelengths produced results which were compatible with the quantitative ultrasound measurements.

    View details for DOI 10.1002/jbio.201500206

    View details for PubMedID 26487250

  • A Route to Laser Angioplasty in the Presence of Fluoroscopy Contrast Media, Using a Nanosecond-Pulsed 355-nm Laser IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS Herzog, A., Steinberg, I., Gaisenberg, E., Nomberg, R., Ishaaya, A. A. 2016; 22 (3)
  • All fiber sensor array for ultrasound sensing PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2016 Gabai, H., Steinberg, I., Eyal, A. 2016; 9708

    View details for DOI 10.1117/12.2209455

    View details for Web of Science ID 000378437000128

  • Shaping photomechanical effects in tissue ablation using 355 nm laser pulses Journal of Biophotonics Herzog, A., Steinberg, I., Ishaaya, A. A. 2016

    View details for DOI 10.1002/jbio.201600094

  • Multiplexing of fiber-optic ultrasound sensors via swept frequency interferometry OPTICS EXPRESS Gabai, H., Steinberg, I., Eyal, A. 2015; 23 (15): 18915-18924

    Abstract

    The use of fiber-optic sensors for ultrasound (US) detection has many advantages over conventional piezoelectric detectors. However, the issue of multiplexing remains a major challenge. Here, a novel approach for multiplexing fiber-optic based US sensors using swept frequency interferometry is introduced. Light from a coherent swept source propagates in an all-fiber interferometric network made of a reference arm and a parallel connection of N sensing arms. Each sensing arm comprises a short polyimide coated sensing section (~4cm), which is exposed to the US excitation, preceded by a delay of different length. When the instantaneous frequency of the laser is linearly swept, the receiver output contains N harmonic beat components which correspond to the various optical paths. Exposing the sensing sections to US excitation introduces phase modulation of the harmonic components. The US-induced signals can be separated in the frequency domain and be extracted from their carriers by common demodulation techniques. The method was demonstrated by multiplexing 4 sensing fibers and detecting microsecond US pulses which were generated by a 2.25MHz ultrasound transducer. The pulses were successfully measured by all sensing fibers without noticeable cross-talk.

    View details for DOI 10.1364/OE.23.018915

    View details for Web of Science ID 000361035300034

    View details for PubMedID 26367554

  • Over 100km long ultra-sensitive dynamic sensing via Gated-OFDR 24TH INTERNATIONAL CONFERENCE ON OPTICAL FIBRE SENSORS Steinberg, I., Shiloh, L., Gabai, H., Eyal, A. 2015; 9634

    View details for DOI 10.1117/12.2194873

    View details for Web of Science ID 000363281800031

  • All-fiber ultrasound sensor array implemented by swept frequency interferometry 24TH INTERNATIONAL CONFERENCE ON OPTICAL FIBRE SENSORS Gabai, H., Steinberg, I., Shiloh, L., Eyal, A. 2015; 9634

    View details for DOI 10.1117/12.2194586

    View details for Web of Science ID 000363281800026

  • Investigation of a Dual modal method for bone pathologies using quantitative ultrasound and Photoacoustics PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2015 Steinberg, I., Gannot, I., Eyal, A. 2015; 9323

    View details for DOI 10.1117/12.2079790

    View details for Web of Science ID 000354517500016

  • Broadband ultrasonic sensor array via optical frequency domain reflectometry PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2015 Gabai, H., Steinberg, I., Eyal, A. 2015; 9323

    View details for DOI 10.1117/12.2080234

    View details for Web of Science ID 000354517500033

  • Tumor Localization Using Magnetic Nanoparticle-Induced Acoustic Signals IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING Tsalach, A., Steinberg, I., Gannot, I. 2014; 61 (8): 2313-2323

    Abstract

    Cancer is a major public health problem worldwide, especially in developed countries. Early detection of cancer can greatly increase both survival rates and quality of life for patients. A magnetoacoustic-based method had been previously proposed for early tumor detection, in a minimal invasive procedure, using magnetic nanoparticles (MNPs). This paper presents a supporting localization algorithm that can provide the clinician with essential tumor location data and could enable a sequential biopsy. It provides localization algorithm development, as well as its validation in both computerized simulations and in vitro experiments. Three-dimensional (3-D) tumor localization is demonstrated with an error of 2.14 mm and an overlapping volume of 84% of the actual tumor. The obtained results are promising and prove the feasibility of tumor localization using a time difference of arrival algorithm along with a magnetoacoustic detection scheme.

    View details for DOI 10.1109/TBME.2013.2286638

    View details for Web of Science ID 000340259900009

    View details for PubMedID 24158469

  • Robust estimation of cerebral hemodynamics in neonates using multilayered diffusion model for normal and oblique incidences JOURNAL OF BIOMEDICAL OPTICS Steinberg, I., Harbater, O., Gannot, I. 2014; 19 (7)

    Abstract

    The diffusion approximation is useful for many optical diagnostics modalities, such as near-infrared spectroscopy. However, the simple normal incidence, semi-infinite layer model may prove lacking in estimation of deep-tissue optical properties such as required for monitoring cerebral hemodynamics, especially in neonates. To answer this need, we present an analytical multilayered, oblique incidence diffusion model. Initially, the model equations are derived in vector-matrix form to facilitate fast and simple computation. Then, the spatiotemporal reflectance predicted by the model for a complex neonate head is compared with time-resolved Monte Carlo (TRMC) simulations under a wide range of physiologically feasible parameters. The high accuracy of the multilayer model is demonstrated in that the deviation from TRMC simulations is only a few percent even under the toughest conditions. We then turn to solve the inverse problem and estimate the oxygen saturation of deep brain tissues based on the temporal and spatial behaviors of the reflectance. Results indicate that temporal features of the reflectance are more sensitive to deep-layer optical parameters. The accuracy of estimation is shown to be more accurate and robust than the commonly used single-layer diffusion model. Finally, the limitations of such approaches are discussed thoroughly.

    View details for DOI 10.1117/1.JBO.19.7.071406

    View details for Web of Science ID 000340490400011

    View details for PubMedID 24604607

  • Monitoring LITT thermal penetration depth using real-time analysis of backscattered light JOURNAL OF BIOPHOTONICS Shacham, R., Steinberg, I., Gandjbakhche, A. H., Gannot, I. 2014; 7 (6): 381-391

    Abstract

    Real-time monitoring of the thermal penetration depth (TPD) is essential in various clinical procedures, such as Laser Interstitial Thermal Therapy (LITT). MRI is commonly used to this end, though bulky and expensive. In this paper, we present an alternative novel method for an optical feedback system based on changes in the diffused reflection from the tissue during treatment. Monte-Carlo simulation was used to deduce the relations between the backscattered pattern and the TPD. Several methods of image analysis are developed for TPD estimation. Each yields a set of parameters which are linearly dependent on the TPD. In order to test these experimentally, tissue samples were monitored in-vitro during treatment at multiple wavelengths. The SNR and coefficient of determination were used to compare the various methods and wavelengths and to determine the preferred method. Such system and algorithms may be used for real-time in-vivo control during laser thermotherapy and other clinical procedures.

    View details for DOI 10.1002/jbio.201200082

    View details for Web of Science ID 000337699300003

    View details for PubMedID 23192946

  • Theoretical and experimental investigation of multispectral photoacoustic Osteoporosis detection method PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2014 Steinberg, I., Hershkovich, H. S., Gannot, I., Eyal, A. 2014; 8943

    View details for DOI 10.1117/12.2039030

    View details for Web of Science ID 000338768500099

  • Multispectral photoacoustic method for the early detection and diagnosis of osteoporosis PHOTONIC THERAPEUTICS AND DIAGNOSTICS IX Steinberg, I., Eyal, A., Gannot, I. 2013; 8565

    View details for DOI 10.1117/12.2005273

    View details for Web of Science ID 000324807200099

  • A new method for tumor detection using induced acoustic waves from tagged magnetic nanoparticles NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE Steinberg, I., Ben-David, M., Gannot, I. 2012; 8 (5): 569-579

    Abstract

    Magnetoacoustic detection is a new method for the noninvasive, early detection of cancer. It uses specific superparamagnetic nanoparticles (NPs) that bind to tumor sites together with magnetic excitation and acoustic detection of the tumor-NPs complex. This work tests the feasibility of such method theoretically and experimentally. An extensive analytic model has been developed that shows an ability to detect small tumors, a few centimeters deep inside the tissue. A series of experiments were conducted to validate the theoretical model. The performance of specially designed solenoids was measured, and the detection of the tumor presence in phantom was demonstrated. Experimental results agree well with the theoretical calculations, providing preliminary proof of concept. We demonstrate the ability to detect a 5-mm diameter spherical tumor located 3 cm deep. Instrumentation and measurements are inexpensive and accurate. The accuracy, speed, and costs of this method show the potential for early detection of cancer.A sensitive and cost effective magentoacoustic tumor detection method is presented in this paper using superparamagnetic nanoparticles. The method is demonstrated in a phantom by detecting a 5-mm diameter spherical tumor located 3 cm deep.

    View details for DOI 10.1016/j.nano.2011.09.011

    View details for Web of Science ID 000305704800004

    View details for PubMedID 22024194

  • Multilayer Mie scattering model for investigation of intracellular structural changes in the nucleolus and cytoplasm International Journal of Optics Saltsberger, S., Steinberg, I., Gannot, I. 2012

    View details for DOI 10.1155/2012/947607

  • The Role of Skew Rays in Biomedical Sensing IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS Steinberg, I., Kaplan, E., Ben-David, M., Gannot, I. 2010; 16 (4): 961-966
  • Ultrashort Laser-Pulse Medical Imaging Encyclopedia of Analytical Chemistry, Ben-David, M., Cohen, R., Harbater, O., Steinberg, I., Tepper, M., Gannot, I. Wiley Online Library. 2010

    View details for DOI 10.1002/9780470027318

  • HOLLOW CORE WAVEGUIDES FOR RADIATION DELIVERY AND SENSING: MONTE CARLO, RAY TRACING COMPUTER SIMULATION OPTICAL FIBERS AND SENSORS FOR MEDICAL DIAGNOSTICS AND TREATMENT APPLICATIONS IX Steinberg, I., Kaplan, E., Ben David, M., Gannot, I. 2009; 7173

    View details for DOI 10.1117/12.815153

    View details for Web of Science ID 000284821100018