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  • A score based on age and DWI volume predicts poor outcome following endovascular treatment for acute ischemic stroke INTERNATIONAL JOURNAL OF STROKE Liggins, J. T., Yoo, A. J., Mishra, N. K., Wheeler, H. M., Straka, M., Leslie-Mazwi, T. M., Chaudhry, Z. A., Kemp, S., Mlynash, M., Bammer, R., Albers, G. W., Lansberg, M. G. 2015; 10 (5): 705-709


    The Houston Intra-Arterial Therapy score predicts poor functional outcome following endovascular treatment for acute ischemic stroke based on clinical variables. The present study sought to (a) create a predictive scoring system that included a neuroimaging variable and (b) determine if the scoring systems predict the clinical response to reperfusion.Separate datasets were used to derive (n?=?110 from the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution 2 study) and validate (n?=?125 from Massachusetts General Hospital) scoring systems that predict poor functional outcome, defined as a modified Rankin Scale score of 4-6 at 90 days.Age (P??05).The Stanford Age and Diffusion-Weighted Imaging and Houston Intra-Arterial Therapy scores can be used to predict poor functional outcome following endovascular therapy with good accuracy. However, these scores do not predict the clinical response to reperfusion. This limits their utility as tools to select patients for acute stroke interventions.

    View details for DOI 10.1111/ijs.12207

    View details for Web of Science ID 000356718000022

    View details for PubMedID 24207136

  • Validating Imaging Biomarkers of Cerebral Edema in Patients With Severe Ischemic Stroke JOURNAL OF STROKE & CEREBROVASCULAR DISEASES Yoo, A. J., Sheth, K. N., Kimberly, W. T., Chaudhry, Z. A., Elm, J. J., Jacobson, S., Davis, S. M., Donnan, G. A., Albers, G. W., Stern, B. J., Gonzalez, R. G. 2013; 22 (6): 742-749


    There is no validated neuroimaging marker for quantifying brain edema. We sought to test whether magnetic resonance imaging (MRI)-based metrics would reliably change during the early subacute period in a manner consistent with edema and whether they would correlate with relevant clinical endpoints.Serial MRI studies from patients in the Echoplanar Imaging Thrombolytic Evaluation Trial with initial diffusion-weighted imaging (DWI) lesion volume >82 cm(3) were analyzed. Two independent readers outlined the hemisphere and lateral ventricle on the involved side and calculated respective volumes at baseline and days 3 to 5. We assessed interrater agreement, volume change between scans, and the association of volume change with early neurologic deterioration (National Institutes of Health Stroke Scale score worsening of ? 4 points), a 90-day modified Rankin scale (mRS) score of 0 to 4, and mortality.Of 12 patients who met study criteria, average baseline and follow-up DWI lesion size was 138 cm(3) and 234 cm(3), respectively. The mean time to follow-up MRI was 62 hours. Concordance correlation coefficients between readers were >0.90 for both hemisphere and ventricle volume assessment. Mean percent hemisphere volume increase was 16.2 8.3% (P < .0001), and the mean percent ventricle volume decrease was 45.6 16.9% (P < .001). Percent hemisphere growth predicted early neurologic deterioration (area under the curve [AUC] 0.92; P = .0005) and 90-day mRS 0 to 4 (AUC 0.80; P = .02).In this exploratory analysis of severe ischemic stroke patients, statistically significant changes in hemisphere and ventricular volumes within the first week are consistent with expected changes of cerebral edema. MRI-based analysis of hemisphere growth appears to be a suitable biomarker for edema formation.

    View details for DOI 10.1016/j.jstrokecerebrovasdis.2012.01.002

    View details for Web of Science ID 000323497700008

    View details for PubMedID 22325573

    View details for PubMedCentralID PMC3529850

  • Hemisphere Volume Is Associated with Neurological Deterioration and Outcome after Malignant Infarction 64th Annual Meeting of the American-Academy-of-Neurology (AAN) Sheth, K., Yoo, A., Gonzalez, R., Kimberly, W., Chaudhry, Z., Elm, J., Jacobson, S., Davis, S., Donnan, G., Albers, G., Stern, B. LIPPINCOTT WILLIAMS & WILKINS. 2012

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