Ekene Enemchukwu

All Publications

• Mirabegron versus solifenacin in multiple sclerosis patients with overactive bladder symptoms: a prospective comparative non-randomized study. Urology Brucker, B. M., Jericevic, D., Rude, T., Enemchukwu, E., Pape, D., Rosenblum, N., Charlson, E. R., Zhovtis-Ryerson, L., Howard, J., Krupp, L., Peyronnet, B. 2020

  Abstract

  OBJECTIVE: To determine the patient-perceived effectiveness and tolerability of mirabegron compared to solifenacin in a multiple sclerosis (MS) population with overactive bladder (OAB) symptoms.MATERIALS AND METHODS: MS patients with OAB symptoms who were not on medication for their urinary symptoms at enrollment were prospectively recruited. Patients enrolled in years 1-2 were prescribed mirabegron, whereas patients enrolled in years 3-4 were prescribed solifenacin. At enrollment and 6-week followup, patients completed several patient reported outcome measures (PROMs). The primary outcome was change in Overactive Bladder Questionnaire Short Form (OAB-q SF) symptom severity and minimal clinically important difference (MCID) achievement. The Patient Assessment of Constipation Symptoms (PAC-SYM) was used to assess bowel function over the treatment period.RESULTS: 61 patients were enrolled. The majority of the mirabegron (70%) and the solifenacin (69%) group achieved the OAB-q SF symptom severity MCID. The solifenacin group had a statistically significant greater decrease in its end of study OAB-q SF score (Delta?=?-37.87 versus -20.43, p=0.02). Constipation improved in the mirabegron group and worsened in the solifenacin group (DeltaPAC-SYM =-0.38 versus +0.22; p=0.02), with 30% of patients prescribed solifenacin experiencing worsening above the MCID threshold.CONCLUSION: Among MS patients, we demonstrated similar response rates to mirabegron and solifenacin, with approximately 50-70% achieving each PROM's MCID. Though this small study showed some short-term evidence that improvement in urinary symptom severity was greater with solifenacin, this potential benefit must be weighed against the observed risk of worsening constipation. Further studies are needed to confirm these findings.

  View details for DOI 10.1016/j.urology.2020.08.008

  View details for PubMedID 32822687

• Sacral Nerve Stimulation in Parkinson's Disease Patients with Overactive Bladder Symptoms. Urology Greenberg, D. R., Sohlberg, E. M., Zhang, C. A., Santini, V. E., Comiter, C. V., Enemchukwu, E. A. 2020

  Abstract

  OBJECTIVES: To assess the efficacy, safety, and outcomes of sacral nerve stimulation (SNS) for Parkinson's Disease (PD) patients with overactive bladder (OAB) symptoms.METHODS: We retrospectively reviewed PD patients who underwent Stage I SNS. Demographics, urodynamic data, and baseline voiding function were analyzed. Efficacy and safety of treatment were determined by rate of progression to Stage II, explantation, and surgical revision. Long-term outcomes were assessed using voiding diaries and/or clinic notes.RESULTS: 60% (9/15) experienced ?50% improvement in urinary parameters and proceeded to Stage II. There was no significant difference in age, BMI, comorbidities, PD disease duration, or levodopa equivalent daily dose between successful and non-successful Stage I patients. However, 100% of female patients experienced Stage I success compared to 44% of male PD patients (p=0.04). Individuals with >12-month follow-up experienced an average reduction of 6 voids/day. No patients required revision or explantation of their device at latest clinic follow-up (22.2 ± 7.8 months). Higher maximal urethral closure pressures (MUCP), detrusor pressure at maximum flow rate (PdetQmax), post-void residual (PVR) volume, and mean BOOI were observed in the Stage I trial failures.CONCLUSION: At our institution, PD patients have a similar rate of progression to Stage II compared to the general population. SNS is an effective therapy that should be considered among the treatment options for PD patients with OAB symptoms. Urodynamic parameters associated with obstruction may be predictive of SNS failure in PD patients and may help guide patient selection, however further studies are needed.

  View details for DOI 10.1016/j.urology.2020.06.063

  View details for PubMedID 32681915

• INCREASED RISK OF INCIDENT DEMENTIA FOLLOWING USE OF ANTICHOLINERGIC AGENTS: A META-ANALYSIS Dmochowski, R., Thai, S., Iglay, K., Enemchukwu, E., Tee, S., Varano, S., Girman, C., Radican, L., Mudd Jr, P. WILEY. 2020: S124?S126

  View details for Web of Science ID 000544770200082

• Balancing the possibility of needing a future incontinence procedure versus a future urethral sling revision surgery: a tradeoff analysis for continent women undergoing pelvic organ prolapse surgery. International urogynecology journal Dallas, K., Rogo-Gupta, L., Syan, R., Enemchukwu, E., Elliott, C. S. 2020

  Abstract

  INTRODUCTION AND HYPOTHESIS: Although urinary incontinence surgery has potential benefits such as preventing de novo stress urinary incontinence in women undergoing pelvic organ prolapse (POP) surgery, it comes with the potential cost of overtreatment and complications. We compared future surgery rates in a population cohort of women undergoing vaginal pelvic organ prolapse surgery.METHODS: All women undergoing POP repair in California from 2005 to 2011 were identified from the Office of Statewide Health Planning and Development databases. Rates of repeat surgery in those with and without concomitant urethral sling procedures were compared. To control for confounding effects, multivariate mixed effects logistic regression models were constructed to compare each woman's individualized risk of undergoing either sling revision surgery or future incontinence surgery.RESULTS: In the cohort, 38,456 underwent a sling procedure at the time of POP repair and 42,858 did not. The future surgery rate was higher for sling-related complications in the POP + sling cohort compared with future incontinence surgery in the POP alone cohort (3.5% versus 3.0% respectively, p<0.001). The difference persisted in multivariate modeling, where most women (60%) are at a higher risk of requiring sling revision surgery compared with needing a future primary incontinence procedure (40%).CONCLUSIONS: Women who undergo vaginal prolapse repair without an incontinence procedure are at a low risk of future incontinence surgery. Women without urinary incontinence who are considering vaginal POP surgery should be informed of the risks and benefits of including a sling procedure.

  View details for DOI 10.1007/s00192-020-04226-3

  View details for PubMedID 32125489

• Current Role of Urethrolysis and Partial Excision in Patients Seeking Revision of Anti-incontinence Sling OBSTETRICAL & GYNECOLOGICAL SURVEY Drain, A., Enemchukwu, E., Shah, N., Syan, R., Rosenblum, N., Nitti, V. W., Brucker, B. M. 2020; 75 (3): 162?63

  View details for DOI 10.1097/OGX.0000000000000784

  View details for Web of Science ID 000526401300011

• Patient satisfaction improved when patients seen by multiple providers at a multidisciplinary pelvic health center Speed, J., Montalvo, C., Cuevas, J., Gurland, B., Enemchukwu, E. WILEY. 2020: S179?S180

  View details for Web of Science ID 000519661200218

• Do preoperative demographics or symptoms predict recurrence in patients following combined surgical repair for pelvic organ prolapse and rectal prolapse? Syan, R., Wallace, S., Gurland, B., Enemchukwu, E. WILEY. 2020: S174?S175

  View details for Web of Science ID 000519661200212

• Racial and Socioeconomic Factors Influence Utilization of Advanced Therapies in Commercially Insured OAB Patients: An Analysis of over 800,000 OAB Patients. Urology Syan, R., Zhang, C. A., Enemchukwu, E. A. 2020

  Abstract

  To determine if racial and/or socioeconomic factors influence advanced therapy utilization for refractory overactive bladder (OAB) amongst the commercially insured.We queried Optum®, a national claims database, between 2003-2017. Non-neurogenic OAB patients were identified using ICD-9/10 diagnosis codes. Demographic and treatment data were collected, including oral medication therapies (anticholinergic, beta3 agonists), and advanced therapies (OnabotulinumtoxinA (BTX), Sacral Nerve Stimulation (SNS), percutaneous tibial nerve stimulation (PTNS)). Associations between patient sociodemographic factors and advanced therapy utilization were explored.Of 4,229,617 OAB patients, 807,612 (19%) received medical therapies, of which 95% received oral medications only and 4.7% received advanced therapies. Asians had the lowest use of oral therapies (14% versus 18-19% in other races/ethnicities, p<0.05), and advanced therapies (0.44% vs 0.71-0.93%, p<0.05). Asians and Hispanics were least likely to utilize SNS therapy and most likely to use PTNS compared to Blacks and Whites. BTX use was similar between races/ethnicities (p<0.05). Female gender (OR 1.65 [CI 1.61,1.69]), younger age (<65) (OR 1.28 [1.25,1.31]), higher annual income ?$40K (OR 1.09 [1.06,1.12]) and prior use of oral medications (OR 3.30 [3.21,3.38] for 1 medication) were significantly associated with receiving advanced therapies. Nonwhite race (OR 0.89 [0.87,0.91]), lower education level (less than a bachelor's degree) (OR 0.97 [0.94,0.99]), and Northeast region were associated with a lower likelihood of receiving advanced therapies (p<0.05 for all).Amongst commercially insured, racial and socioeconomic factors predict utilization of advanced OAB therapies, including race/ethnicity, age, gender, education level, and region.

  View details for DOI 10.1016/j.urology.2020.04.109

  View details for PubMedID 32439551

• Trends in the Diagnosis and Management of Combined Rectal and Vaginal Pelvic Organ Prolapse. Urology Speed, J. M., Zhang, C. A., Gurland, B., Enemchukwu, E. 2020

  Abstract

  To examine the rates of surgical repair of comorbid rectal prolapse (RP) and pelvic organ prolapse (POP) over time in a large population-based cohort.We queried Optum®, a national administrative claims database, from 2003-2017. We evaluated female patients age 18 or older with a diagnosis of POP and/or RP. Sociodemographic characteristics, comorbidities, and rates of procedures were collected.We identified 481,051 women diagnosed with RP and/or POP. Only 2.0% of women in the cohort had comorbid POP and RP. While 29.9% of women with RP had dual prolapse, only 2.1% of women with POP had both diagnoses. Overall, 25.8% of women had one or more surgical repairs. Surgical repairs were done in 26.0% of women with POP, 15.0% of women with RP, and 48.2% of women with comorbid POP/RP, though only 19.8% of patients with dual diagnoses had both RP and POP repairs. Over the study period, the rate of multidisciplinary surgical repairs increased by 2.7-fold.The prevalence of comorbid RP and POP among women in our cohort is low (2.0%). Rates of multidisciplinary surgery have increased possibly due to the increased use of imaging, laparoscopic surgery, and awareness of the shared pathophysiology of the disease.

  View details for DOI 10.1016/j.urology.2020.05.010

  View details for PubMedID 32439552

• Surgical approach, complications, and reoperation rates of combined rectal and pelvic organ prolapse surgery. International urogynecology journal Wallace, S. L., Syan, R., Enemchukwu, E. A., Mishra, K., Sokol, E. R., Gurland, B. 2020

  Abstract

  Our primary objective was to determine rectal prolapse (RP) and pelvic organ prolapse (POP) reoperation rates and postoperative < 30-day complications after combined RP and POP surgery at a single institution.This was an IRB-approved retrospective cohort study of all female patients who received combined RP and POP surgery at a single tertiary care center from 2008 to 2019. Recurrence was defined as the need for subsequent repeat RP or POP surgery at any point after the index surgery. Surgical complications were separated into Clavien-Dindo classes.Sixty-three patients were identified, and 18.3% (12/63) had < 30-day complications (55% Clavien-Dindo grade 1; 27% Clavien-Dindo grade 2; 18% Clavien-Dindo grade 4). Of patients undergoing combined abdominal RP and POP repair, no postoperative < 30-day complications were noted in the MIS group compared to 37.5% of those patients in the laparotomy group (p?

  View details for DOI 10.1007/s00192-020-04394-2

  View details for PubMedID 32577789

• Current Role of Urethrolysis and Partial Excision in Patients Seeking Revision of Anti-Incontinence Sling FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY Drain, A., Enemchukwu, E., Shah, N., Syan, R., Rosenblum, N., Nitti, V. W., Brucker, B. M. 2019; 25 (6): 409?14

  View details for DOI 10.1097/SPV.0000000000000596

  View details for Web of Science ID 000496508600002

• Clinical phenotypic presentation of rectal prolapse varies with age Neshatian, L., Lee, A., Wallace, S., Enemchukwu, E., Rogo-Gupta, L., Mishra, K., Garcia, P., Nguyen, L. B., Gurland, B. WILEY. 2019

  View details for Web of Science ID 000481874100073

• Outcomes of Sacral Nerve Stimulation for Treatment of Refractory Overactive Bladder Among Octogenarians. Neuromodulation : journal of the International Neuromodulation Society Greenberg, D. R., Syan, R., Young-Lin, N., Comiter, C. V., Enemchukwu, E. 2019

  Abstract

  OBJECTIVE: Sacral nerve stimulation (SNS) is an effective treatment for refractory overactive bladder (OAB). However, advanced age is often cited as a reason to avoid SNS in the elderly. This study evaluates the safety and efficacy of SNS for refractory OAB among our octogenarian population.METHODS: A retrospective review from a single institution was performed on all SNS lead placements from December 1998 to June 2017 for refractory OAB. Octogenarians were characterized as 80years of age or older at the time of Stage I. Efficacy and safety were determined by the rate of progression to Stage II, subsequent need for multimodal therapy, and rate of surgical revision and explantation. All patients were followed for a minimum of 12months.RESULTS: Of 374 patients in this study, 37 (9.9%) were octogenarians. There was no difference in gender, race, smoking history, or prior OAB treatment regimens between cohorts. The rate of progression to Stage II was 56.8% for octogenarians compared to 60.5% for nonoctogenarians (p = 0.66). The rate of surgical revision, explantation, and need for multimodal therapy did not differ between groups. Subgroup analysis of octogenarians did not reveal any significant differences between successful and nonsuccessful Stage I patients.CONCLUSIONS: The safety and efficacy of SNS was similar between cohorts. This result suggests that SNS is a safe and effective therapy that should be considered among the treatment options for refractory OAB in octogenarian patients. Further studies are needed to determine predictive factors of Stage I success in elderly patients.

  View details for DOI 10.1111/ner.12981

  View details for PubMedID 31215713

• Exploring the bowel and bladder dysfunction relationship in a multiple sclerosis population Jericevic, D. K., Peyronnet, B., Rude, T., Enemchukwu, E., Palmerola, R., Sussman, R., Pape, D., Rosenblum, N., Sammarco, C., Zhovtis-Ryerson, L., Kister, I., Howard, J., Krupp, L., Brucker, B. WILEY. 2019: S125?S126

  View details for Web of Science ID 000462357800153

• Transvaginal Suture-Based Repair. The Urologic clinics of North America Enemchukwu, E. A. 2019; 46 (1): 97?102

  Abstract

  An estimated 300,000 women undergo pelvic organ prolapse (POP) surgery in the United States every year at a cost of more than 1 billion dollars per year. The prevalence of POP is approximately 2.9% to 8%, and increases with age. Apical support is required to achieve successful prolapse repair. As the search for the safest, most durable, surgical repair continues, transvaginal native tissue repairs have the advantage of providing minimally invasive surgical repairs without the added risk of abdominal, laparoscopic, or robotic surgery while avoiding the risk of mesh augmentation.

  View details for PubMedID 30466707

• Basic Evaluation of the Patient with Pelvic Floor Dysfunction Challenging Clinical Scenarios in Female Pelvic Medicine Syan, R., Enemchukwu, E., Dobberfuhl, A., Comiter, C. Springer International Publishing. 2019
• Association Between Concomitant Hysterectomy and Repeat Surgery for Pelvic Organ Prolapse Repair in a Cohort of Nearly 100,000 Women. Obstetrics and gynecology Dallas, K., Elliott, C. S., Syan, R., Sohlberg, E., Enemchukwu, E., Rogo-Gupta, L. 2018

  Abstract

  OBJECTIVE: To evaluate the association of hysterectomy at the time of pelvic organ prolapse (POP) repair with the risk of undergoing subsequent POP surgery in a large population-based cohort.METHODS: Data from the California Office of Statewide Health Planning and Development were used in this retrospective cohort study to identify all women who underwent an anterior, apical, posterior or multiple compartment POP repair at nonfederal hospitals between January 1, 2005, and December 31, 2011, using Current Procedural Terminology and International Classification of Diseases, 9th Revision procedure codes. Women with a diagnosis code indicating prior hysterectomy were excluded, and the first prolapse surgery during the study period was considered the index repair. Demographic and surgical characteristics were explored for associations with the primary outcome of a repeat POP surgery. We compared reoperation rates for recurrent POP between patients who did compared with those who did not have a hysterectomy at the time of their index POP repair.RESULTS: Of the 93,831 women meeting inclusion criteria, 42,340 (45.1%) underwent hysterectomy with index POP repair. Forty-eight percent of index repairs involved multiple compartments, 14.0% included mesh, and 48.9% included an incontinence procedure. Mean follow-up was 1,485 days (median 1,500 days). The repeat POP surgery rate was lower in those patients in whom hysterectomy was performed at the time of index POP repair, 3.0% vs 4.4% (relative risk [RR] 0.67, 95% CI 0.62-0.71). Multivariate modeling revealed that hysterectomy was associated with a decreased risk of future surgery for anterior (odds ratio [OR] 0.71, 95% CI 0.64-0.78), apical (OR 0.76, 95% CI 0.70-0.84), and posterior (OR 0.69, 95% CI 0.65-0.75) POP recurrence. The hysterectomy group had increased lengths of hospital stay (mean 2.2 days vs 1.8 days, mean difference 0.40, 95% CI 0.38-0.43), rates of blood transfusion (2.5% vs 1.5, RR 1.62, 95% CI 1.47-1.78), rates of perioperative hemorrhage (1.5% vs 1.1%, RR 1.32, 95% CI 1.18-1.49), rates of urologic injury or fistula (0.9% vs 0.6%, RR 1.66, 95% CI 1.42-1.93), rates of infection or sepsis (0.9% vs 0.4%, RR 2.12, 95% CI 1.79-2.52), and rate of readmission for an infectious etiology (0.7% vs 0.3%, RR 2.54, 95% CI 2.08-3.10) as compared with those who did not undergo hysterectomy.CONCLUSION: We demonstrate in a large population-based cohort that hysterectomy at the time of prolapse repair is associated with a decreased risk of future POP surgery by 1-3% and is independently associated with higher perioperative morbidity. Individualized risks and benefits should be included in the discussion of POP surgery.

  View details for PubMedID 30334856

• Rates and Risk Factors for Future Stress Urinary Incontinence Surgery After Pelvic Organ Prolapse Repair in a Large Population Based Cohort in California. Urology Syan, R., Dallas, K. B., Sohlberg, E., Rogo-Gupta, L., Elliott, C. S., Enemchukwu, E. A. 2018

  Abstract

  OBJECTIVES: To determine the rate and risk factors for future stress incontinence (SUI) surgery in a large population based cohort of previously continent women following pelvic organ prolapse (POP) repair without concomitant SUI treatment.METHODS: Data from the Office of Statewide Health Planning and Development (OSHPD) was used to identify all women who underwent anterior, apical or combined antero-apical POP repair without concomitant SUI procedures in the state of California between 2005-2011 with at least one-year follow-up. Patient and surgical characteristics were explored for associations with subsequent SUI procedures.RESULTS: Of 41,689 women undergoing anterior or apical POP surgery, 1,504 (3.6%) underwent subsequent SUI surgery with a mean follow-up time of 4.1 years. Age (OR 1.01), obesity (OR 1.98), use of mesh at the time of POP repair (OR 2.04), diabetes mellitus (OR 1.19), White race and combined antero-apical repair (OR 1.30) were associated with an increased odds of future SUI surgery.CONCLUSIONS: The rate of subsequent surgery for de novo SUI following POP repair on a population level is low. Patient and surgical characteristics may alter a woman's individual risk and should be considered in surgical planning.

  View details for PubMedID 30222995

• Current Role of Urethrolysis and Partial Excision in Patients Seeking Revision of Anti-Incontinence Sling. Female pelvic medicine & reconstructive surgery Drain, A., Enemchukwu, E., Shah, N., Syan, R., Rosenblum, N., Nitti, V. W., Brucker, B. M. 2018

  Abstract

  OBJECTIVES: Stress urinary incontinence is highly prevalent and sling surgery has increased since 2000. Urethrolysis traditionally had been standard management of complications after anti-incontinence surgery; however, partial excision is a less aggressive option. This study describes the different populations in a contemporary cohort that undergo sling excision and urethrolysis and their surgical outcomes.METHODS: Chart analysis was performed on patients assigned Current Procedural Terminology codes for removal or revision of sling for stress incontinence, urethrolysis, or revision of graft at our institution from 2010 to 2015. Demographics, indications, outcomes, and subsequent treatment were evaluated.RESULTS: A total of 110 patients underwent surgery and were included. Partial excision was performed on 82 patients and urethrolysis on 28 patients. About 32.7% had prior revision, and median length to revision was 3.1 years. Overall success was 75.0% for urethrolysis and 86.6% for partial excision. Without concomitant sling placement, stress incontinence developed in 25.0% of urethrolysis and 21.6% of partial excision patients. New onset overactive bladder symptoms developed in 21.4% of urethrolysis patients and 7.3% of partial excision, which was significantly different (P = 0.039).CONCLUSIONS: Both approaches had good success, 75.0% for formal urethrolysis and 86.6% for partial excision. New onset urgency was lower for partial excision, but rates of all other complications were similar. These procedures are often used for different patient populations, and thus, outcomes are not meant to be directly compared. Future work on sling revision should report these procedures separately.

  View details for PubMedID 29787462

• CONCOMITANT HYSTERECTOMY LOWERS THE RATE OF RECURRENT PROLAPSE SURGERY FOR ALL COMPARTMENTS IN A COHORT OF OVER 100,000 WOMEN Enemchukwu, E., Dallas, K., Syan, R., Sohlberg, E., Elliott, C., Rogo-Gupta, L. WILEY. 2018: S556

  View details for Web of Science ID 000427016100064

• IS PROPHYLACTIC STRESS INCONTINENCE SURGERY NECESSARY AT THE TIME OF PELVIC ORGAN PROLAPSE REPAIR? - RATES OF FUTURE SURGERY IN A LARGE POPULATION BASED COHORT IN CALIFORNIA Syan, R., Dallas, K., Sohlberg, E., Rogo-Gupta, L., Elliott, C., Enemchukwu, E. WILEY. 2018: S567

  View details for Web of Science ID 000427016100081

• Tibial Nerve and Sacral Neuromodulation in the Elderly Patient Curr Bladder Dysfunct Rep Sohlberg, E., Greenberg, D., Enemchukwu, E. 2018 ; 288 (13)

  View details for DOI 10.1007/s11884-018-0493-0

• Racial and Socioeconomic Disparities in Short-term Urethral Sling Surgical Outcomes UROLOGY Dallas, K. B., Sohlberg, E. M., Elliott, C. S., Rogo-Gupta, L., Enemchukwu, E. 2017; 110: 70?75

  Abstract

  To evaluate the association of racial and socioeconomic factors with the risk of adverse events in the first 30 days following urethral sling placement.We accessed nonpublic data from the Office of Statewide Health Planning and Development in California from 2005 to 2011. All female patients who underwent an ambulatory urethral sling procedure in the entire state of California over the study period were identified (Current Procedural Terminology 57288). Our main outcome was any unplanned hospital visits within 30 days of the patient's surgery in the form of an inpatient admission, revision surgery, or emergency department visit.A total of 28,635 women who underwent outpatient urethral sling placement were identified. Within 30 days, 1628 women (5.7%) had at least 1 unplanned hospital visit. In the adjusted multivariate model, black race and Medicaid insurance status were both independently associated with increased odds of having an unplanned hospital visit (odds ratio?1.80, P?

  View details for PubMedID 28847692

• CO2 Laser Treatment is Effective for Symptoms of Vaginal Atrophy JOURNAL OF UROLOGY Anger, J. T., Enemchukwu, E. A. 2017; 198 (6): 1229?30

  View details for DOI 10.1016/j.juro.2017.09.003

  View details for Web of Science ID 000417150900004

  View details for PubMedID 29061287

• THE EFFECT OF MIXED URINARY INCONTINENCE ON CATHETERIZATION RATE AFTER INTRADETRUSOR ONABOTULINUMTOXINA: IS STRESS INCONTINENCE PROTECTIVE? Glass, D., Hoffman, D. S., Enemchukwu, E. A., Brucker, B. M., Nitti, V. W. WILEY-BLACKWELL. 2017: S149?S150

  View details for Web of Science ID 000394664900282

• Abdominal Imaging Following Urinary Reconstruction: Recommendations and Pitfalls CURRENT BLADDER DYSFUNCTION REPORTS Davenport, M. T., Enemchukwu, E. A. 2016; 11 (4): 291?99

  View details for DOI 10.1007/s11884-016-0394-z

  View details for Web of Science ID 000388814900002

• EFFICACY AND TOLERABILITY OF MIRABEGRON IN MULTIPLE SCLEROSIS: A PROSPECTIVE Rude, T. L., Enemchukwu, E., Sammarco, C., Nitti, V., Brucker, B. WILEY-BLACKWELL. 2016: S49

  View details for Web of Science ID 000369726700111

• MANAGEMENT OF PATIENTS SEEKING REVISION OF ANTI-INCONTINENCE SLING:OUTCOMES OF URETHROLYSIS VS. PARTIAL EXCISION Drain, A., Enemchukwu, E., Nitti, V., Brucker, B. Society of Urodynamics and Female Pelvic Medicine and Urogenital reconstruction. 2016
• DIAGNOSIS OF GENITOURINARY FISTULAE Textbook of Female Urology and Urogynecology Brucker, B., Enemchukwu, E. 2016
• Transvesical Repair of Vesicovaginal Fistula Hinman's Atlas of Urologic Surgery Rosenblum, N., Enemchukwu, E. 2016
• Autologous Pubovaginal Sling for the Treatment of Concomitant Female Urethral Diverticula and Stress Urinary Incontinence. Urology Enemchukwu, E., Lai, C., Reynolds, W. S., Kaufman, M., Dmochowski, R. 2015; 85 (6): 1300-1303

  Abstract

  To describe our experience with concomitant repair of urethral diverticula and stress urinary incontinence (SUI) with autologous pubovaginal sling (PVS).A retrospective chart review between January 2006 and 2013 identified 38 women undergoing concomitant diverticulectomy and rectus sheath PVS. Patient demographics, presenting symptoms, prior urethral surgery, concomitant procedures, postoperative outcomes, and complications were evaluated.The mean duration of symptoms was 56.7 months. Eleven patients presented with recurrent diverticula and 5 patients had prior SUI surgery (3 midurethral slings, 1 PVS, and 1 bulking agent). One patient had a prior urethrolysis. All other slings were cut or excised at the time of surgery. All women had demonstrable SUI on cough stress test or urodynamics. The mean follow-up was 12.7 months. All postoperative voiding cystourethrograms were negative for contrast extravasation. One patient required prolonged (>4 weeks) suprapubic tube drainage for urinary retention. Four others required an additional 1 week of suprapubic tube drainage. Eighteen patients (47%) reported mixed urinary symptoms. Of these, 9 had complete resolution, whereas 9 experienced significant improvement. Overall, 97.3% reported resolution of their dysuria, dyspareunia, and pain symptoms and 90% reported complete resolution of their SUI symptoms. There were 2 urethral diverticula recurrences and 2 SUI recurrences. Perioperative complications, including hemorrhage, sling erosion, or urethrovaginal fistulas, were not observed.Concomitant PVS placement is a safe and effective treatment option for SUI in patients undergoing urethral diverticulectomy. The risks and benefits should be weighed and management individualized.

  View details for DOI 10.1016/j.urology.2015.02.022

  View details for PubMedID 26099875

• Comparative Revision Rates of Inflatable Penile Prostheses Using Woven Dacron (R) Fabric Cylinders JOURNAL OF UROLOGY Enemchukwu, E. A., Kaufman, M. R., Whittam, B. M., Milam, D. F. 2013; 190 (6): 2189-2193

  Abstract

  American Medical Systems (AMS) CX and LGX penile prostheses use woven Dacron® fabric to produce girth, and length and girth expansion, respectively. Cylinder expansion, while desirable, can result in wear of the material which, over time, may lead to device failure. Therefore, we compared girth and length expanding vs girth expanding cylinder survival rates. In addition, we determined the impact of parylene coating on penile prosthesis revision performed for mechanical reasons.All patient information forms from AMS 700? CX and LGX/Ultrex penile prosthesis implantation performed in the United States from January 1997 through August 2008 were retrospectively analyzed (55,013). Device failure was defined as time to first revision. Survival rates of the 2 groups were analyzed and compared, and survival curves were generated.AMS 700 Ultrex/LGX parylene and CX parylene devices demonstrated equivalent estimated survival rates (88.7% vs 89.5%, respectively, log rank p=0.6811). The parylene coated CX and Ultrex/LGX devices outperformed the nonparylene coated devices on survival analysis.This analysis demonstrated no significant difference in 7-year survival between current generation girth expanding (700 CX) and length and girth expanding (700 LGX/Ultrex) prostheses. This analysis also demonstrated that the parylene coating of the cylinder wall contact surfaces significantly reduced the revision rate of the 700 CX and 700 LGX/Ultrex inflatable penile prostheses.

  View details for DOI 10.1016/j.juro.2013.06.112

  View details for Web of Science ID 000327441000077

  View details for PubMedID 23845458

• Safety and Efficacy of Sling for Persistent Stress Urinary Incontinence After Bulking Injection UROLOGY Koski, M. E., Enemchukwu, E. A., Padmanabhan, P., Kaufman, M. R., Scarpero, H. M., Dmochowski, R. R. 2011; 77 (5): 1076-1080

  Abstract

  To evaluate the impact of injectable agents on subsequent incontinence surgery outcomes to assess safety and efficacy of this treatment combination. Periurethral bulking agents are a minimally invasive treatment option for stress urinary incontinence (SUI), but often lack durability necessitating further surgical intervention.Retrospective review of 43 patients with SUI following bulking agent who underwent subsequent sling placement from November 2000 to September 2009 were evaluated for demographics, symptoms, urodynamics (UDS), bulking agent characteristics, concomitant procedures, pad requirements per day (PPD), subjective outcomes, and complications.Mean patient age was 67 years, with mean follow-up of 37.3 months. All demonstrated SUI, and mixed urinary incontinence (MUI) was noted in 81.4%. Almost half (48.8%) had undergone a prior antiincontinence procedure. Mean number of injections was 3. After a bulking injection, 25 autologous fascia pubovaginal slings, 13 midurethral slings, and 5 biological pubovaginal slings were placed. Concomitant pelvic surgery was performed in 37.2%. Postoperatively, mean PPD decreased from 5.3 to 0.65, with a 60.5% subjective cure rate (no pads or leakage under any circumstances). No association was seen between number or type of injection, or type of sling with regards to patient outcomes. Results were significantly related to concomitant surgery (P = .007). SUI recurred in 8 patients (18.6%), which was not statistically associated with other parameters. Complications included urinary retention (8 patients) de novo urgency (1 patient), UTI (4 patients), abdominal wound infection (3 patients), and cystotomy (1 patient).Prior treatment with bulking agents does not appear to negatively affect outcomes for future antiincontinence surgery in our patient population.

  View details for DOI 10.1016/j.urology.2010.10.010

  View details for Web of Science ID 000290026700016

  View details for PubMedID 21216448