School of Medicine


Showing 221-239 of 239 Results

  • Hannes Vogel MD

    Hannes Vogel MD

    Professor of Pathology and of Pediatrics (Pediatric Genetics) and, by courtesy, of Neurosurgery and of Comparative Medicine at the Stanford University Medical Center

    Current Research and Scholarly Interests My research interests include nerve and muscle pathology, mitochondrial diseases, pediatric neurooncology, and transgenic mouse pathology.

  • Xinnan Wang

    Xinnan Wang

    Associate Professor of Neurosurgery

    Current Research and Scholarly Interests Mechanisms underlying mitochondrial dynamics and function, and their implications in neurological disorders.

  • Thomas J. Wilson

    Thomas J. Wilson

    Clinical Assistant Professor, Neurosurgery

    Bio Dr. Thomas J. Wilson was born in Omaha, Nebraska. He attended the University of Nebraska College of Medicine, earning his MD with highest distinction. While a medical student, he was awarded a Howard Hughes Medical Institute Research Training Fellowship and spent a year in the lab of Dr. Rakesh Singh at the University of Nebraska. He was also elected to the prestigious Alpha Omega Alpha Honor Medical Society. He completed his residency training in neurological surgery at the University of Michigan and was mentored by Dr. Lynda Yang and Dr. John McGillicuddy in peripheral nerve surgery. Following his residency, he completed a fellowship in peripheral nerve surgery at the Mayo Clinic in Rochester, Minnesota, working with Dr. Robert Spinner. He is now Clinical Assistant Professor and Co-Director of the Center for Peripheral Nerve Surgery at Stanford University. He is also currently endeavoring to earn a Master of Public Health (MPH) degree from the Bloomberg School of Public Health at Johns Hopkins University. His research interests include peripheral nerve outcomes research using large data sets and multi-institutional registries, clinical trials advancing options for patients with peripheral nerve pathologies, and translational research focused on deriving methods for data-driven intraoperative decision-making using intraoperative electrophysiology, advanced imaging techniques, and genetic expression information. His wife, Dr. Monique Wilson, is a practicing dermatologist in the Bay Area.

  • Max Wintermark

    Max Wintermark

    Professor of Radiology (Neuroimaging and Neurointervention) and, by courtesy, of Neurology, of Neurosurgery and of Psychiatry and Behavioral Sciences at the Stanford University Medical Center

    Current Research and Scholarly Interests Stroke, cerebrovascular diseases, cardiovascular diseases, carotid arteries, coronary arteries
    Stroke diagnosis, stroke triage, stroke treatment
    Traumatic brain injury
    Traumatic brain injury diagnosis and prognosis
    Psychiatric disorders, including depression and post-traumatic stress disorders
    Epilepsy
    Movement disorders, including essential tremor and Parkinson?s tremor
    Brain tumors
    Image-guided clinical trials
    CT, multidetector-row CT, perfusion-CT, CT angiography
    MRI, diffusion-weighted MRI, perfusion-weighted MRI, diffusion tensor imaging, functional MRI
    Brain perfusion imaging techniques
    Functional imaging
    Post-processing techniques of medical images, signal and image processing
    3D visualization
    MR-guided focused ultrasound

  • Albert J. Wong, M.D.

    Albert J. Wong, M.D.

    Professor of Neurosurgery

    Current Research and Scholarly Interests Our goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective.

  • Yu Wei Wu

    Yu Wei Wu

    Affiliate, Neurosurgery

    Bio I am interested in the neural circuits for motor control and how it is affected under the progression of Parkinson?s disease (PD). Currently I focus on dissecting the role of the striatal spiny projection neurons on integrating information from other brain areas, which are highly altered in PD. By incorporating various tools and state-of-the-art approaches, such as two-photon imaging/uncaging, patch-clamp electrophysiology, optogenetic manipulation of neural circuit and computational simulation, I aim to provide a comprehensive view, in the neuronal circuitry level, of how motor control is achieved and what goes wrong during the pathophysiological changes in PD, so that potential new therapeutic targets will be discovered to help PD patients.

    My past training has quipped me with various research skills including:
    1.Brain slice electrophysiology for studying ion channel physiology and synaptic transmission.
    2.Two-photon calcium imaging for monitor subcellular neuronal activity in brain slices and in vivo.
    3.Optics and microscopy development.
    4.Computer programming for image processing, data analysis, and instrumental control.
    5.Optogenetic techniques for controlling targeted neuronal circuits with transgenic mice and AAV viral injection.
    6.Immunohistochemistry and biochemical essays.

    These skills enable me not only to design and perform bench works independently but also capable to have a working model and a big picture in mind. I have a solid background in biology and neurophysiology, and my broad research skills further facilitate collaboration with experts from multidisciplinary. In summary, I have demonstrated a record for successfully completing research projects, and my strong motivation and substantial research skills have prepared me well to achieve my goal.

  • Heng Zhao

    Heng Zhao

    Professor (Research) of Neurosurgery

    Current Research and Scholarly Interests My lab is focused on developing novel therapeutic methods against stroke using rodent models. We study protective effect of postconditioning, preconditioning and mild hypothermia. The rationale for studying three means of neuroprotection is that we may discover mechanisms that these treatments have in common. Conversely, if they have differing mechanisms, we will be able to offer more than one treatment for stroke and increase a patient’s chance for recovery.

  • J. Bradley Zuchero

    J. Bradley Zuchero

    Assistant Professor of Neurosurgery

    Current Research and Scholarly Interests Glia are a frontier of neuroscience, and overwhelming evidence from the last decade shows that they are essential regulators of all aspects of the nervous system. The Zuchero Lab aims to uncover how glial cells regulate neural development and how their dysfunction contributes to diseases like multiple sclerosis (MS) and in injuries like stroke.

    Although glia represent more than half of the cells in the human brain, fundamental questions remain to be answered. How do glia develop their highly specialized morphologies and interact with neurons to powerfully control form and function of the nervous system? How is this disrupted in neurodegenerative diseases and after injury? By bringing cutting-edge cell biology techniques to the study of glia, we aim to uncover how glia help sculpt and regulate the nervous system and test their potential as novel, untapped therapeutic targets for disease and injury.

    We are particularly interested in myelin, the insulating sheath around neuronal axons that is lost in diseases like MS. How do oligodendrocytes- the glial cell that produces myelin in the central nervous system- form and remodel myelin, and why do they fail to regenerate myelin in disease? Our current projects aim to use cell biology and neuroscience approaches to answer these fundamental questions. Ultimately we hope our work will lead to much-needed therapies to promote remyelination in patients.

  • Corinna Zygourakis

    Corinna Zygourakis

    Assistant Professor of Neurosurgery at the Stanford University Medical Center

    Current Research and Scholarly Interests My goal is to translate research into real-world action and decision-making so that my work can impact patients and the institutions in which they receive care. With a research focus on healthcare cost and quality of care, I approach neurosurgery in a unique way?one that applies business operations, economics, and healthcare delivery principles to our field. I have pursued formal LEAN business training, and believe in the importance of working together with other departments and administrators, as well as physicians and surgeons on the hospital and national level, to effect change. During my residency, I developed and led a multi-departmental prospective study at UCSF called OR SCORE (OR Surgical Cost Reduction Project) that brought together surgeons from the neurosurgery, orthopedics and ENT departments with nurses and administrators. OR SCORE successfully reduced surgical supply costs by nearly one million dollars in its first year by providing >60 surgeons with price transparency scorecards. This work led to a first-author publication in JAMA Surgery, but more importantly, set the foundation for further quality improvement and cost reduction efforts across the UCSF hospital system.

    A volunteer neurosurgical mission trip to Guadalajara, Mexico, where limited resources create an OR environment that is strikingly more frugal than the U.S., inspired me to lead another project aimed at quantifying and reducing operating room waste at UCSF. I have also conducted research looking at the safety and outcomes of overlapping surgery, as well as several projects to define the factors underlying variation in cost for neurosurgical care using UCSF?s hospital data and national databases like the National Inpatient Sample, Vizient (formerly known as University Health Consortium), and Medicare.

    As a clinical fellow at Johns Hopkins, I continued and expanded these research efforts. I designed and implemented an Enhanced Recovery after Surgery (ERAS) protocol at the Johns Hopkins Bayview hospital. This protocol standardized care for our spine patients, emphasizing pre-operative rehabilitation, psychiatric and nutritional assessments, and smoking cessation, as well as intra- and post-operative multi-modal pain therapy, early mobilization, and standardized antibiotic and bowel regimens. I also collaborated with engineers in the Johns Hopkins Carnegie Center for Surgical Innovation to develop better algorithms for intra-operative CT imaging, and provided assistance with operations to a basic science study looking at the role of cerebrospinal fluid drainage and duraplasty in a porcine model of spinal cord injury.

    At Stanford, I am building a research group focused on: (1) perfecting paradigms for delivery of high-end technology in spinal care, including robotics and navigation, (2) implementing cost and quality strategies in large healthcare systems, and (3) computational analysis of big-data to effect real-time risk stratification and decision making in spine surgery. I'm excited to collaborate with my peers across surgical and medical departments, as well as business and engineering colleagues.

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