School of Medicine


Showing 1-42 of 42 Results

  • Manuel Amieva

    Manuel Amieva

    Professor of Pediatrics (Infectious Diseases) and of Microbiology and Immunology

    Current Research and Scholarly Interests My laboratory studies how bacteria colonize our bodies for long periods of time, and how interactions between bacteria and the epithelial surfaces of the gastrointestinal tract and skin may lead to disease. Epithelial surfaces are the first barrier against infection, but they also where our bodies meet and co-evolve with the microbial world.. Several of our studies have focused on the epithelial junctions as a target for bacterial pathogens. The host epithelium uses its epithelial junctions to form a tight but dynamic barrier with an external surface that is inhospitable to microbial attachment, secretes anti-microbial compounds, and has a rapid rate of self-renewal. The balance in the microbe-epithelial relationship results in silent commensalism or symbiosis; an imbalance results in diseases ranging from acute bacterial invasive disease to chronic ulcers or carcinoma.

    Our laboratory has developed novel microscopy applications such as quantitative 3D confocal microscopy, electron microscopy, time-lapse imaging, microinjection and micromanipulation to visualize the interaction of pathogens with epithelial cells in culture and in animal and human tissues. Many of out studies focus on the gastric pathogen Helicobacter pylori, but we have also expanded our investigations to include the intestinal pathogens Listeria monocytogenes and Salmonella enterica, and the skin pathogen and colonizer Staphylococcus aureus. I believe that elucidating how microbes communicate with and alter our epithelial cells at a molecular level will be important for finding novel therapeutic targets to control mucosal colonization and prevent invasive disease.

    Using this perspective, we have uncovered several novel concepts of how bacteria colonize and breach our epithelial surfaces. For example, we discovered that Helicobacter pylori target the intercellular junctions, and in particular that the virulence factor CagA affects junction assembly and cell polarity. This confers H. pylori the ability to extract nutrients and grow directly on the epithelial surface. We also found that these properties of CagA have consequences for cellular transformation of the epithelium. For instance, we showed that H. pylori affect the activity and state of epithelial stem cells in the stomach by colonizing the epithelial surface deep in the gastric glands. This gland-associated population is essential for pathological inflammation and hyperplasia in animal models, and confers significant colonization advantages to the bacteria. Our Listeria research uncovered a new mechanism and site where bacteria can breach the gastrointestinal epithelial barrier to invade. We found that Listeria find their receptor for invasion at sites of epithelial senescence, where the epithelial junctions undergo dynamic turnover. To study Salmonella and H. pylori we have developed a human organoid model to study their interactions with human gut epithelium in vitro. To study Staphylococcus aureus pathogenesis, we have developed methods to visualize infection at the scale of a single bacterial microcolony using an organoid culture system of human keratinocytes and fibroblasts that grow into a 3D skin-equivalent. We recently identified several proteins at the eptithelial junctions as host factors involved in the pathogenesis of one of Staphylococcus aureus major toxins.

  • Ann M. Arvin

    Ann M. Arvin

    Lucile Salter Packard Professor of Pediatrics and Professor of Microbiology and Immunology

    Current Research and Scholarly Interests Our laboratory investigates the pathogenesis of varicella zoster virus (VZV) infection, focusing on the functional roles of particular viral gene products in pathogenesis and virus-cell interactions in differentiated human cells in humans and in Scid-hu mouse models of VZV cell tropisms in vivo, and the immunobiology of VZV infections.

  • Helen M. Blau

    Helen M. Blau

    The Donald E. and Delia B. Baxter Foundation Professor and Director, Baxter Laboratory for Stem Cell Biology

    Current Research and Scholarly Interests Prof. Helen Blau's research area is regenerative medicine with a focus on stem cells. Her research on nuclear reprogramming and demonstrating the plasticity of cell fate using cell fusion is well known and her laboratory has also pioneered the design of biomaterials to mimic the in vivo microenvironment and direct stem cell fate. Current findings are leading to more efficient iPS generation, cell based therapies by dedifferentiation a la newts, and discovery of novel molecules and therapies.

  • Matthew Bogyo

    Matthew Bogyo

    Professor of Pathology and of Microbiology and Immunology and, by courtesy, of Chemical and Systems Biology

    Current Research and Scholarly Interests Our lab uses chemical, biochemical, and cell biological methods to study protease function in human disease. Projects include:

    1) Design and synthesis of novel chemical probes for serine and cysteine hydrolases.

    2) Understanding the role of hydrolases in bacterial pathogenesis and the human parasites, Plasmodium falciparum and Toxoplasma gondii.

    3) Defining the specific functional roles of proteases during the process of tumorogenesis.

    4) In vivo imaging of protease activity

  • John  Boothroyd

    John Boothroyd

    Burt and Marion Avery Professor of Immunology

    Current Research and Scholarly Interests We are intereseted in the interaction between the protozoan parasite Toxoplasma gondii and its mammalian host. We use a combination of molecular and genetic tools to understand how this obligate intracellular parasite can invade almost any cell it encounters, how it co-opts a host cell once inside and how it evades the immune response to produce a life-long, persistent infection.

  • Jan Carette

    Jan Carette

    Associate Professor of Microbiology and Immunology

    Current Research and Scholarly Interests Our research focuses on the identification of host genes that play critical roles in the pathogenesis of infectious agents including viruses. We use haploid genetic screens in human cells as an efficient approach to perform loss-of-function studies. Besides obtaining fundamental insights on how viruses hijack cellular processes and on host defense mechanisms, it may also facilitate the development of new therapeutic strategies.

  • Chia Yu Alex Chang

    Chia Yu Alex Chang

    Instructor, Microbiology & Immunology - Baxter Laboratory

    Current Research and Scholarly Interests Duchenne muscular dystrophy (DMD) is an X-chromosome-linked genetic disease that is caused by a mutation in the dystrophin gene and affects 1 in every 3500 boys. DMD patients suffer progressive muscle wasting and eventual cardiorespiratory failure that results in an early death in the second or third decade of life. Although extensive research effort has been invested, lack of a good mouse model that mimics the cardiac failure hinders research. We have developed a novel mouse model that exhibit all the symptoms found in DMD patients and our research is aimed at understanding the cardiac failure in DMD for future therapeutic interventions. Our mouse model fully recapitulates the DMD symptoms because we also took into account of the size of human protection DNA on chromosomal ends (telomere) compared to mouse. We would like to study the cause of cardiac failure in our mouse model by 1) determine if telomere shortening is specific to cardiomyocytes, 2) evaluate the level of cellular damage caused by oxidative stress and 3) identify the source of oxidative stress. These experiments will help us to better understand cardiac failure in DMD patients and allow testing of therapeutic interventions.

  • Yueh-hsiu Chien

    Yueh-hsiu Chien

    Professor of Microbiology & Immunology

    Current Research and Scholarly Interests Contribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses.

  • Wah Chiu

    Wah Chiu

    Professor of Photon Science, Bioengineering and of Microbiology and Immunology

    Current Research and Scholarly Interests My research include methodology improvements in single particle cryo-EM for atomic resolution structure determination of molecules and molecular machines, as well as in cryo-ET of cells and organelles towards subnanometer resolutions. We have collaborations with many researchers around the country and outside USA on understanding biological processes such as protein folding, virus assembly and disassembly, pathogen-host interactions, signal transduction, transport across cytosol and membrane.

  • Mark M. Davis

    Mark M. Davis

    Director, Stanford Institute for Immunity, Transplantation and Infection and the Burt and Marion Avery Family Professor

    Current Research and Scholarly Interests Molecular mechanisms of lymphocyte recognition and differentiation; Systems immunology and human immunology; vaccination and infection.

  • Elizabeth Egan

    Elizabeth Egan

    Assistant Professor of Pediatrics (Infectious Diseases) and of Microbiology and Immunology

    Current Research and Scholarly Interests Malaria is a parasitic disease transmitted by mosquitos that is a leading cause of childhood mortality globally. Public health efforts to control malaria have historically been hampered by the rapid development of drug resistance. The goal of our research is to understand the molecular determinants of critical host-pathogen interactions in malaria, with a focus on the erythrocyte host cell. Our long-term goal is to develop novel approaches to prevent or treat malaria and improve child health.

  • Shirit Einav

    Shirit Einav

    Associate Professor of Medicine (Infectious Diseases) and of Microbiology and Immunology

    Current Research and Scholarly Interests My lab's goals are to better understand virus-host protein interactions, identify host partners conservatively required by multiple viruses, and develop broad-spectrum host-centered antiviral approaches with a high genetic barrier for resistance. We combine novel proteomic approaches, including microfluidics platforms, with molecular virology, biochemical, and genomic approaches to achieve these goals. We focus on viruses from the Flaviviridae family (hepatitis C and dengue), as well as HIV.

  • Stephen J. Galli, MD

    Stephen J. Galli, MD

    The Mary Hewitt Loveless, M.D. Professor in the School of Medicine and Professor of Pathology and of Microbiology and Immunology

    Current Research and Scholarly Interests The goals of Dr. Galli's laboratory are to understand the regulation of mast cell and basophil development and function, and to develop and use genetic approaches to elucidate the roles of these cells in health and disease. We study both the roles of mast cells, basophils, and IgE in normal physiology and host defense, e.g., in responses to parasites and in enhancing resistance to venoms, and also their roles in pathology, e.g., anaphylaxis, food allergy, and asthma, both in mice and humans.

  • Jeffrey S.  Glenn, M.D., Ph.D.

    Jeffrey S. Glenn, M.D., Ph.D.

    Professor of Medicine (Gastroenterology and Hepatology) and of Microbiology and Immunology

    Current Research and Scholarly Interests Dr. Glenn's primary interest is in molecular virology, with a strong emphasis on translating this knowledge into novel antiviral therapies. Other interests include exploitation of hepatic stem cells, engineered human liver tissues, liver cancer, and new biodefense antiviral strategies.

  • Harry B Greenberg

    Harry B Greenberg

    Co-Director, Spectrum, Associate Dean, Research, The Joseph D. Grant Professor in the School of Medicine and Professor of Microbiology and Immunology

    Current Research and Scholarly Interests Molecular mechanisms of pathogenesis; determinants of protective immunity; host range and tissue tropism in liver and GI tract pathogenic viruses and studies of vaccines in people.

  • KC Huang

    KC Huang

    Professor of Bioengineering and of Microbiology and Immunology

    Current Research and Scholarly Interests How do cells determine their shape and grow?
    How do molecules inside cells get to the right place at the right time?

    Our group tries to answer these questions using a systems biology approach, in which we integrate interacting networks of protein and lipids with the physical forces determined by the spatial geometry of the cell. We use theoretical and computational techniques to make predictions that we can verify experimentally using synthetic, chemical, or genetic perturbations.

  • Juliana Idoyaga

    Juliana Idoyaga

    Assistant Professor of Microbiology and Immunology

    Current Research and Scholarly Interests The Idoyaga Lab is focused on the function and biology of dendritic cells, which are specialized antigen-presenting cells that initiate and modulate our body?s immune responses. Considering their importance in orchestrating the quality and quantity of immune responses, dendritic cells are an indisputable target for vaccines and therapies.

    Dendritic cells are not one cell type, but a network of cells comprised of many subsets or subpopulations with distinct developmental pathways and tissue localization. It is becoming apparent that each dendritic cell subset is different in its capacity to induce and modulate specific types of immune responses; however, there is still a lack of resolution and deep understanding of dendritic cell subset functional specialization. This gap in knowledge is an impediment for the rational design of immune interventions. Our research program focuses on advancing our understanding of mouse and human dendritic cell subsets, revealing their endowed capacity to induce distinct types of immune responses, and designing novel strategies to exploit them for vaccines and therapies.

  • Peter K.  Jackson

    Peter K.  Jackson

    Professor of Microbiology and Immunology (Baxter Labs)

    Current Research and Scholarly Interests Cell cycle and cyclin control of DNA replication .

  • Prasanna Jagannathan

    Prasanna Jagannathan

    Assistant Professor of Medicine (Infectious Diseases) and of Microbiology and Immunology

    Bio I am an Infectious Diseases specialist with a research program in translational immunology focused on malaria-specific immune responses in pregnancy and infancy. My current research program is to further our understanding of the mechanisms of clinical immunity to malaria through field-based studies, and to better understand the immunologic consequences of malaria control interventions.

  • Karla Kirkegaard

    Karla Kirkegaard

    Violetta L. Horton Research Professor and Professor of Microbiology and Immunology

    Current Research and Scholarly Interests The biochemistry of RNA-dependent RNA polymerase function, the cell biology of the membrane rearrangements induced by positive-strand RNA virus infection of human cells, and the genetics of RNA viruses, which, with their high error rates, live at the brink of error catastrophe, are investigated in the Kirkegaard laboratory.

  • Holden Maecker

    Holden Maecker

    Professor (Research) of Microbiology and Immunology

    Current Research and Scholarly Interests I'm interested in immune monitoring of T cell responses to chronic pathogens and cancer, and the correlation of T cell response signatures with disease protection.

  • AC Matin

    AC Matin

    Professor of Microbiology and Immunology

    Current Research and Scholarly Interests 1. Improvement of our newly discovered cancer prodrug regimen that permits noninvaisve visualization of drug activation. 2. Tracking tumors & cancer metastases using bacterial magnetite and newly developed single-cell tracking by MRI. 3. Molecular basis of bacterial planktonic and biofilm antibiotic resistance on Earth and under space microgravity -- development of new countermeasures; 4. Bioremediation.

  • Hugh McDevitt

    Hugh McDevitt

    Professor of Microbiology and Immunology and of Medicine, Emeritus

    Current Research and Scholarly Interests The structure of class II major histocompatibility complex molecules, their role in antigen presentation, and in the immune response in health and disease with emphasis on type 1 diabetes and rheumatoid arthritis; the role of lymphokines (tumor necrosis factor alpha, lymphotoxin) in autoimmunity.

  • Edward Mocarski

    Edward Mocarski

    Professor of Microbiology and Immunology, Emeritus

    Current Research and Scholarly Interests My research interests focus on the biology and pathogenesis of cytomegalovirus (CMV), an opportunistic pathogen that causes significant disease worldwide. We developed global approaches and produced key insights into the areas of CMV gene regulation, DNA replication and packaging, maturation, impact on the host cell, disease pathogenesis, latency and reactivation, host cell signaling and chemokine system. These diverse findings address key aspects of the virus-host interaction.

  • Denise M. Monack

    Denise M. Monack

    Professor of Microbiology and Immunology

    Current Research and Scholarly Interests The primary focus of my research is to understand the genetic and molecular mechanisms of intracellular bacterial pathogenesis. We use several model systems to study complex host-pathogen interactions in the gut and in immune cells such as macrophages and dendritic cells. Ultimately we would like to understand how Salmonella persists within certain hosts for years in the face of a robust immune response.

  • Garry Nolan

    Garry Nolan

    Rachford and Carlota Harris Professor

    Current Research and Scholarly Interests Dr. Nolan's group uses high throughput single cell analysis technology cellular biochemistry to study autoimmunity, cancer, virology (influenza & Ebola), as well as understanding normal immune system function. Using advanced flow cytometric techniques such as Mass Cytometry, MIBI (ion beam imaging), CODEX and computational biology approaches, we focus on understanding disease processes at the single cell level. We have a strong interest in cancer immunotherapy and pathogen-host interactions.

  • Peter Parham

    Peter Parham

    Professor of Structural Biology and of Microbiology and Immunology

    Current Research and Scholarly Interests The Parham laboratory investigates the biology, genetics, and evolution of MHC class I molecules and NK cell receptors.

  • Philip A. Pizzo, M.D.

    Philip A. Pizzo, M.D.

    David and Susan Heckerman Professor and Professor of Microbiology and Immunology

    Bio Philip Pizzo, MD, is the David and Susan Heckerman Professor and Founding Director of the Stanford Distinguished Careers Institute. Pizzo served as Dean of the Stanford School of Medicine from April 2001 to December 1, 2012, where he was also the Carl and Elizabeth Naumann Professor of Pediatrics and of Microbiology and Immunology. Dr. Pizzo has devoted much of his distinguished medical career to the diagnosis, management, prevention and treatment of childhood cancers and the infectious complications that occur in children whose immune systems are compromised by cancer and AIDS. He has also been a leader in academic medicine, championing programs and policies to improve the future of science, education and healthcare in the US and beyond.
    Pizzo received his MD degree with Honors and Distinction in Research from the University of Rochester in 1970, and completed an internship and residency at Children?s Hospital Medical Center in Boston, a teaching fellowship at Harvard Medical School, and a clinical and research fellowship in pediatric oncology at the National Cancer Institute. Pizzo served as head of the Institute?s infectious disease section, chief of the NCI?s pediatric department, and acting scientific director for NCI?s Division of Clinical Sciences between 1973 and 1996. Before joining Stanford in 2001, he was the physician-in-chief of Children?s Hospital in Boston and Chair of the Department of Pediatrics at Harvard Medical School, where he was also the Thomas Morgan Rotch Professor of Pediatrics.
    Dr. Pizzo is the author of more than 615 scientific articles and 16 books and monographs, including Principles and Practice of Pediatric Oncology, the Seventh Edition of which was published in 2015.
    Pizzo has received numerous awards and honors, among them the Public Health Service Outstanding Service Medal in 1995, the Barbara Bohen Pfiefer Award for Scientific Excellence in 1991, the Elizabeth Kubler-Ross Award in 2008, the Ronald McDonald Charities ?Award of Excellence? in 2009, and the John and Emma Bonica Public Service Award in 2013. He is the 2012 recipient of the John Howland Award, the highest honor for lifetime achievement bestowed by the American Pediatric Society. He has been elected to a number of prestigious organizations and societies, including the Association of American Physicians, the American Society of Clinical Investigation, the American Pediatric Society and the Institute of Medicine of the National Academy of Sciences, where he was also elected to the Governing Council. The IOM became the National Academy of Medicine in 2015. He has served as Chair of the Association of Academic Health Centers and Chair of the Council of Deans of the Association of American Medical Colleges, and was elected to the Board of Directors of the American Society for Clinical Oncology and the Infectious Diseases Society of America. He was President of the International Immunocompromised Host Society (1998-2011). He served on the Governing Board for the California Institute of Regenerative Medicine from 2004-2012. In 2009 he was elected to the Board of Trustees of the University of Rochester and the Board of Overseers of Koc University in Istanbul, Turkey. He was a member of the Board of Directors of MRI Interventions (2013-2017) and the Academic Advisory Council for Merritt Hawkins (2015-present). In 2014 he was elected to the Board of Directors of the Ludwig Institute for Cancer Research and in 2015 he was elected to the Board of Directors of Global Blood Therapeutics. He also serves as Editor-in-Chief of Current Opinion in Pediatrics.

  • Charles G. Prober, MD

    Charles G. Prober, MD

    Senior Associate Vice Provost for Health Education and Professor of Pediatrics (Infectious Diseases) and of Microbiology and Immunology

    Current Research and Scholarly Interests My research interest is in the epidemiology, pathophysiology, prevention, and treatment of infections in children. Much of this research has focused on viral infections, especially those caused by herpes simplex virus (HSV). I have conducted a number of studies concerned with the epidemiology of HSV-2 infections in pregnant women, their partners, and neonates.

  • David A. Relman

    David A. Relman

    Thomas C. and Joan M. Merigan Professor and Professor of Microbiology and Immunology

    Current Research and Scholarly Interests My investigative program focuses on human-microbe interactions and human microbial ecology, and primarily concerns the ecology of human indigenous microbial communities; a secondary interest concerns the classification of humans with systemic infectious diseases, based on features of genome-wide gene transcript abundance patterns and pther aspects of the host response.

  • Peter Sarnow

    Peter Sarnow

    Professor of Microbiology and Immunology

    Current Research and Scholarly Interests Our laboratory studies virus-host interactions with an emphasis microRNA-mediated gene regulation and on translational control. The mechanism by which a liver-specific microRNA regulates hepatitis C virus genome replication is under intense scrutiny. In addition, the mechanism of internal ribosome entry in certain cellular and viral mRNAs and its biological role in growth and development is being investigated.

  • David Schneider

    David Schneider

    Professor of Microbiology and Immunology

    Current Research and Scholarly Interests We study innate immunity and microbial pathogenesis. We have been studying models for a variety of bacterial infections including: Listeria, Mycobacteria, Salmonella and Streptococcus as well as some fungi, malaria and viruses. Our current focus is to determine how we recover from infections.

  • Robert Siegel

    Robert Siegel

    Professor (Teaching) of Microbiology and Immunology

    Current Research and Scholarly Interests My work is primarily involved in medical education and curricular development, especially in the areas of infectious disease, virology, HIV, and molecular biology. Projects included electronic applications to science education, three dimensional model building, service learning, and the development of undergraduate research projects.

  • Upinder Singh

    Upinder Singh

    Professor of Medicine (Infectious Diseases & Geographic Medicine) and of Microbiology and Immunology

    Current Research and Scholarly Interests Our lab elucidates the molecular basis of pathogenesis of the protozoan parasite Entamoeba histolytica. We use genetic and genomic approaches to identify novel virulence determinants and to characterize the global epidemiology of the parasite.

  • Justin L. Sonnenburg

    Justin L. Sonnenburg

    Associate Professor of Microbiology and Immunology

    Current Research and Scholarly Interests We are interested in the basic principles that govern interactions within the intestinal microbiota and between the microbiota and the host. To pursue these aims, we colonize germ-free (gnotobiotic) mice with simplified, model microbial communities, apply systems approaches (e.g. functional genomics), and use genetic tools for the host and microbes to gain mechanistic insight into emergent properties of the host-microbial super-organism.

  • Lucy Tompkins

    Lucy Tompkins

    Lucy Becker Professor in Medicine and of Microbiology and Immunology

    Current Research and Scholarly Interests Genetic and cellular basis of pathogenicity of Helicobacter pylori. Molecular epidemiology, hospital epidemiology, quality improvement in healthcare associated infections.

  • Wang,Taia

    Wang,Taia

    Assistant Professor of Medicine (Infectious Diseases) and of Microbiology and Immunology

    Current Research and Scholarly Interests Studies in our lab are aimed at defining mechanisms in human immunity and disease. We are particularly interested the hypothesis that IgG repertoire diversity is a central driver of heterogeneity in human immune functioning and susceptibility to infectious diseases. Our work is defining how diversity that exists in the IgG Fc domain repertoire among people, which we define by serum IgG subclass and Fc glycoform distributions, impacts immune processes such as vaccine responses and susceptibility to antibody-dependent enhancement of dengue disease (Wang TT, Cell. 2015 and Wang TT, Science. 2017). IgG subclass and Fc glycoform distributions are key regulators of immunity because these determine the structure of Fc domains within immune complexes that form during vaccination or infection. Fc structure, in turn, determines the affinity of immune complexes for various Fc receptors on effector cells. Thus, we are studying how the Fc domain repertoire of an individual impacts the quality of effector cell responses that can be recruited during immune activation and how selectivity of effector responses contributes to immunity and disease.

    We are particularly interested in training students and postdocs who will go on to be independent investigators in mechanistic studies relevant to human disease.


    Current clinical studies:
    Recruiting:

    An Open Label Study of IgG Fc Glycan Composition in Human Immunity
    Principal Investigator: Taia T. Wang, MD, PhD
    ClinicalTrials.gov Identifier:
    NCT01967238

  • Ellen Yeh

    Ellen Yeh

    Assistant Professor of Biochemistry, of Pathology and of Microbiology and Immunology

    Current Research and Scholarly Interests The chemistry and biology of the unusual plastid organelle, the apicoplast, in malaria parasites

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