School of Medicine
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Shan X. Wang
Leland T. Edwards Professor in the School of Engineering and Professor of Electrical Engineering and, by courtesy, of Radiology (Molecular Imaging Program at Stanford)
Current Research and Scholarly Interests Dr. Wang is the Director of Stanford Center for Magnetic Nanotechnology, and the Co-PI of the Stanford Center for Cancer Nanotechnology Excellence. His research interests lie in nanotechnology and information storage, including magnetic/spintronic biochips, in vitro diagnostics, cell sorting, magnetic nanoparticles, nano-patterning, spin electronic materials and sensors, as well as magnetic integrated inductors and transformers.
Assistant Professor of Medicine (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly Interests Studies in our lab are aimed at defining mechanisms in human immunity and disease. We are particularly interested the hypothesis that IgG repertoire diversity is a central driver of heterogeneity in human immune functioning and susceptibility to infectious diseases. Our work is defining how diversity that exists in the IgG Fc domain repertoire among people, which we define by serum IgG subclass and Fc glycoform distributions, impacts immune processes such as vaccine responses and susceptibility to antibody-dependent enhancement of dengue disease (Wang TT, Cell. 2015 and Wang TT, Science. 2017). IgG subclass and Fc glycoform distributions are key regulators of immunity because these determine the structure of Fc domains within immune complexes that form during vaccination or infection. Fc structure, in turn, determines the affinity of immune complexes for various Fc receptors on effector cells. Thus, we are studying how the Fc domain repertoire of an individual impacts the quality of effector cell responses that can be recruited during immune activation and how selectivity of effector responses contributes to immunity and disease.
We are particularly interested in training students and postdocs who will go on to be independent investigators in mechanistic studies relevant to human disease.
Current clinical studies:
An Open Label Study of IgG Fc Glycan Composition in Human Immunity
Principal Investigator: Taia T. Wang, MD, PhD
Assistant Professor of Pediatrics (Stem Cell Transplantation and Regenerative Medicine)
Current Research and Scholarly Interests Pediatric Hematopoietic Stem Cell Transplantation
Genetic Immune Diseases
Clinical Associate Professor, Pediatrics - General Pediatrics
Current Research and Scholarly Interests Research interests include: 1) Childhood obesity, community-based interventions to increase physical activity 2) Impact of medical-legal collaboration on child and family health.
Director, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Virginia & D.K. Ludwig Professor for Clinical Investigation in Cancer Research, Professor of Developmental Biology and, by courtesy, of Biology
Current Research and Scholarly Interests Stem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis.
Professor of Pathology and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests Epigenetic Reprogramming, Direct conversion of fibroblasts into neurons, Pluripotent Stem Cells, Neural Differentiation: implications in development and regenerative medicine
Assistant Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests Translational research in rare and undiagnosed diseases. Basic and clinical research in cardiomyopathy genetics, mechanisms, screening, and treatment. Investigating novel agents for treatment of hypertrophic cardiomyopathy and new mechanisms in heart failure. Cardiovascular screening and genetics in competitive athletes, disease gene discovery in cardiomyopathy and rare disease. Informatics approaches to rare disease and multiomics. Molecular transducers of physical activity bioinformatics.