School of Medicine
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Professor of Photon Science and of Structural Biology
Current Research and Scholarly Interests Ubiquitin signaling: structure, function, and therapeutics
Ubiquitin is a small protein modifier that is ubiquitously produced in the cells and takes part in the regulation of a wide range of cellular activities such as gene transcription and protein turnover. The key to the diversity of the ubiquitin roles in cells is that it is capable of interacting with other cellular proteins either as a single molecule or as different types of chains. Ubiquitin chains are produced through polymerization of ubiquitin molecules via any of their seven internal lysine residues or the N-terminal methionine residue. Covalent interaction of ubiquitin with other proteins is known as ubiquitination which is carried out through an enzymatic cascade composed of the ubiquitin-activating (E1), ubiquitin-conjugating (E2), and ubiquitin ligase (E3) enzymes. The ubiquitin signals are decoded by the ubiquitin-binding domains (UBDs). These domains often specifically recognize and non-covalently bind to the different ubiquitin species, resulting in distinct signaling outcomes.
We apply a combination of the structural (including protein crystallography, small angle x-ray scattering, cryo-electron microscopy (Cryo-EM) etc.), biocomputational and biochemical techniques to study the ubiquitylation and deubiquitination processes, and recognition of the ubiquitin chains by the proteins harboring ubiquitin-binding domains. Current research interests including SARS-COV2 proteases and their interactions with polyubiquitin chains and ubiquitin pathways in host cell responses, with an ultimate goal of providing strategies for effective therapeutics with reduced levels of side effects.
Protein self-assembly processes and applications.
The Surface layers (S-layers) are crystalline protein coats surrounding microbial cells. S-layer proteins (SLPs) regulate their extracellular, self-assembly by crystallizing when exposed to an environmental trigger. We have demonstrated that the Caulobacter crescentus SLP readily crystallizes into sheets both in vivo and in vitro via a calcium-triggered multistep assembly pathway. Observing crystallization using a time course of Cryo-EM imaging has revealed a crystalline intermediate wherein N-terminal nucleation domains exhibit motional dynamics with respect to rigid lattice-forming crystallization domains. Rate enhancement of protein crystallization by a discrete nucleation domain may enable engineering of kinetically controllable self-assembling 2D macromolecular nanomaterials. In particular, this is inspiring designing robust novel platform for nano-scale protein scaffolds for structure-based drug design and nano-bioreactor design for the carbon-cycling enzyme pathway enzymes. Current research focuses on development of nano-scaffolds for high throughput in vitro assays and structure determination of small and flexible proteins and their interaction partners using Cryo-EM, and applying them to cancer and anti-viral therapeutics.
Multiscale imaging and technology developments.
Multimodal, multiscale imaging modalities will be developed and integrated to understand how molecular level events of key enzymes and protein network are connected to cellular and multi-cellular functions through intra-cellular organization and interactions of the key machineries in the cell. Larger scale organization of these proteins will be studied by solution X-ray scattering and Cryo-EM. Their spatio-temporal arrangements in the cell organelles, membranes, and cytosol will be further studied by X-ray fluorescence imaging and correlated with cryoEM and super-resolution optical microscopy. We apply these multiscale integrative imaging approaches to biomedical, and environmental and bioenergy research questions with Stanford, DOE national labs, and other domestic and international collaborators.
Rebecca D. Walker
Clinical Associate Professor, Emergency Medicine
Current Research and Scholarly Interests Interests include international development in emergency care, healthcare disparities, wilderness medicine, human rights, administration
Associate Professor of Pediatrics (Systems Medicine), of Biomedical Data Science and, by courtesy, of Psychiatry and Behavioral Sciences
Current Research and Scholarly Interests Systems biology for design of clinical solutions that detect and treat disease
Associate Professor of Surgery (Pediatric Surgery) at the Lucile Salter Packard Children's Hospital and, by courtesy, of Bioengineering
Current Research and Scholarly Interests Health Technology Innovation
Brian A. Wandell
Isaac and Madeline Stein Family Professor and Professor, by courtesy, of Electrical Engineering, of Ophthalmology and at the Graduate School of Education
Current Research and Scholarly Interests Models and measures of the human visual system. The brain pathways essential for reading development. Diffusion tensor imaging, functional magnetic resonance imaging and computational modeling of visual perception and brain processes.
C. Jason Wang, MD, PhD
Associate Professor of Pediatrics (General Pediatrics) at the Lucile Salter Packard Children's Hospital and of Medicine (Primary Care and Outcomes Research)
Bio Dr. Wang is the Director of Center for Policy, Outcomes and Prevention. Prior to coming to Stanford in 2011, he was a faculty member at Boston University Schools of Medicine and Public Health. His other professional experiences include working as a management consultant with McKinsey and Company and serving as the project manager for Taiwan's National Health Insurance Reform Task-force. His current interests include: 1) COVID-19 related policies; 2) developing tools for assessing and improving the value of healthcare; 3) facilitating the use of mobile technology in improving quality of care; 4) supporting competency-based medical education curriculum, and 5) engaging in healthcare delivery and payment reforms.
Postdoctoral Research Fellow, Radiation Biology
Bio Jinglong was trained in a single-molecule lab in Institute Jacques Monod and École Normale Supérieure Paris and obtained his PhD degree from University of Paris in 2019, France. He dissected the molecular machinery of human and bacterial Non-homologous end joining, and interrogated the mechanism of SpCas9 plasticity on targeting DNA with deviant PAMs using single-molecule nanomanipulation tools. Jinglong joined the Frock lab in Jan 2020, and he is working on DSB-related chromosome topological changes and genomic interactions.
Kevin Wang, MD, PhD
Assistant Professor of Dermatology
Current Research and Scholarly Interests The Wang lab takes an interdisciplinary approach to studying fundamental mechanisms controlling gene expression in mammalian cells, and how epigenetic mechanisms such as DNA methylation, chromatin modifications, and RNA influence chromatin dynamics to affect gene regulation.
Clinical Associate Professor, Pediatrics
Current Research and Scholarly Interests Evaluation and management of the febrile young infant and infections in hospitalized children (eg, UTIs, CNS infections, pneumonia); promotion of appropriate antibiotic use.
Professor of Emergency Medicine and, by courtesy, of Pediatrics (Hospital Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests - Disparities in Emergency Medical Services for children.
- Efficacy of novel interventions for pediatric access to care.
- Teaching and supporting community-initiated interventions and programs internationally.
Paul J. Wang, MD
Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center and, by courtesy, of Bioengineering
Current Research and Scholarly Interests Dr. Wang's research centers on the development of innovative approaches to the treatment of arrhythmias, including more effective catheter ablation techniques, more reliable implantable devices, and less invasive treatments. Dr. Wang's clinical research interests include atrial fibrillation, ventricular tachycardia, syncope, and hypertrophic cardiomyopathy. Dr. Wang has active collaborations with Bioengineering, Mechanical Engineering, and Electrical Engineering Departments at Stanford.
Shan X. Wang
Leland T. Edwards Professor in the School of Engineering and Professor of Electrical Engineering and, by courtesy, of Radiology (Molecular Imaging Program at Stanford)
Current Research and Scholarly Interests Shan Wang was named the Leland T. Edwards Professor in the School of Engineering in 2018. He directs the Center for Magnetic Nanotechnology and is a leading expert in biosensors, information storage and spintronics. His research and inventions span across a variety of areas including magnetic biochips, in vitro diagnostics, cancer biomarkers, magnetic nanoparticles, magnetic sensors, magnetoresistive random access memory, and magnetic integrated inductors.
Sui Wang, PhD
Assistant Professor of Ophthalmology
Current Research and Scholarly Interests Our research focuses on understanding the molecular mechanisms that underlie retinal development and diseases. We utilize genetic and genomic tools to uncover how different types of retinal cells, including retinal neurons, glia and the vasculature, respond to developmental cues and disease insults at the epigenomic and transcriptional levels, and how they interact and collectively contribute to the integrity of the retina.
1. Retinal cell fate specification.
We are using genetic tools and methods, such as in vivo plasmid electroporation and CRISPR, to dissect the roles of cis-regulatory elements and transcription factors in controlling retinal cell fate specification.
2. The multicellular responses elicited by diabetes in the retina.
Diabetes can induce multicellular responses in the retina, including vascular lesions, glial dysfunction and neurodegeneration, all of which contribute to retinopathy. We are using diabetic rats as models to investigate the detailed molecular mechanisms underlying the diabetes-induced multicellular responses, and the disease mechanisms of diabetic retinopathy.
3. Molecular tools that allow for cell type-specific labeling and manipulation in vivo.
Cis-regulatory elements, such as enhancers, play essential roles in directing tissue/cell type-specific and stage-specific expression. We are interested in identifying enhancers that can drive cell type-specific expression in the retina and brain, and incorporating them into plasmid or AAV based delivery systems.
Taia T. Wang, MD, PhD, MSCI
Assistant Professor of Medicine (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly Interests Laboratory of Mechanisms in Human Immunity and Disease Pathogenesis
Studies in our lab are aimed at defining mechanisms in human immunity and disease. We are particularly interested the hypothesis that diversity in antibody-based signaling that arises from diversity in IgG antibodies and their receptors, is a central driver of heterogeneity in human immune functioning and susceptibility to infectious diseases. We are studying how the Fc domain repertoire of an individual impacts the quality of effector cell responses that can be recruited during immune activation and how selectivity of effector responses contributes to immunity and disease.
SARS-CoV-2, dengue viruses, influenza viruses, disease pathogenesis, influenza vaccines
Current clinical studies:
An Open Label Study of IgG Fc Glycan Composition in Human Immunity
Principal Investigator: Taia T. Wang, MD, PhD
Associate Professor of Neurosurgery
Current Research and Scholarly Interests Mechanisms underlying mitochondrial dynamics and function, and their implications in neurological disorders.
Katja Gabriele Weinacht, MD, PhD
Assistant Professor of Pediatrics (Stem Cell Transplantation and Regenerative Medicine)
Current Research and Scholarly Interests Pediatric Hematopoietic Stem Cell Transplantation
Genetic Immune Diseases
Clinical Associate Professor, Pediatrics - General Pediatrics
Current Research and Scholarly Interests Research interests include: 1) Childhood obesity, community-based interventions to increase physical activity 2) Impact of medical-legal collaboration on child and family health.
Director, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Virginia & D.K. Ludwig Professor for Clinical Investigation in Cancer Research, Professor of Developmental Biology and, by courtesy, of Biology
Current Research and Scholarly Interests Stem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis.
Professor of Pathology and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests Epigenetic Reprogramming, Direct conversion of fibroblasts into neurons, Pluripotent Stem Cells, Neural Differentiation: implications in development and regenerative medicine
Assistant Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests Translational research in rare and undiagnosed diseases. Basic and clinical research in cardiomyopathy genetics, mechanisms, screening, and treatment. Investigating novel agents for treatment of hypertrophic cardiomyopathy and new mechanisms in heart failure. Cardiovascular screening and genetics in competitive athletes, disease gene discovery in cardiomyopathy and rare disease. Informatics approaches to rare disease and multiomics. Molecular transducers of physical activity bioinformatics.
Professor of Pediatrics (Endocrinology) at the Lucile Salter Packard Children's Hospital, Emeritus
Current Research and Scholarly Interests My research interests cover a number of areas in Pediatric Endocrinology and Diabetes. I am PI of the Stanford Center for the NIH-funded Type-1 Diabetes TrialNet group. TrialNet conducts clinical trials directed at preventing or delaying the onset of Type 1 diabetes. I am an investigator in DirecNet, another NIH-funded study group, which is devoted to evaluating glucose sensors and the role of technology on the management of diabetes.
Clinical Associate Professor, Psychiatry and Behavioral Sciences
Bio Dr. Wilson is a licensed clinical psychologist with expertise on the effects of trauma across the lifespan. She provides clinical services for children, adolescents, adults, and families affected by trauma and other forms of anxiety and stress. Dr. Wilson also leads an active research program focused on relationships between childhood trauma and health risk behavior in adolescence and adulthood. She is the Principal Investigator of GIRLTALK: We Talk, a longitudinal study funded by the National Institute of Child Health and Human Development (NICHD) that examines links from childhood violence exposure to dating violence and sexual risk in young women from low-income communities in Chicago. Dr. Wilson has authored or co-authored thirty journal articles and book chapters related to these topics, and she regularly presents her work at local and national conferences. She is on the editorial board of the Journal of Youth and Adolescence.
Jeffrey J. Wine
Benjamin Scott Crocker Professor of Human Biology
Current Research and Scholarly Interests The goal is to understand how a defective ion channel leads to the human genetic disease cystic fibrosis. Studies of ion channels and ion transport involved in gland fluid transport. Methods include SSCP mutation detection and DNA sequencing, protein analysis, patch-clamp recording, ion-selective microelectrodes, electrophysiological analyses of transmembrane ion flows, isotopic metho
Associate Professor of Obstetrics and Gynecology (Reproductive and Stem Cell Biology) at the Stanford University Medical Center
Current Research and Scholarly Interests The Winn Laboratory seeks to understand the unique aspects of human placental biology that contribute to pregnancy complications. Abnormalities in placental biology lead to more than 25% of pregnancy complications that impact the health of mothers and their babies. The primary focus of Dr. Winn's lab is to understand human placentation and preeclampsia pathogenesis. Both basic science and translational approaches are undertaken.
Professor of Computer Science, Emeritus
Bio Professor Winograd's focus is on human-computer interaction design and the design of technologies for development. He directs the teaching programs and HCI research in the Stanford Human-Computer Interaction Group, which recently celebrated it's 20th anniversary. He is also a founding faculty member of the Hasso Plattner Institute of Design at Stanford (the "d.school") and on the faculty of the Center on Democracy, Development, and the Rule of Law (CDDRL)
Winograd was a founding member and past president of Computer Professionals for Social Responsibility. He is on a number of journal editorial boards, including Human Computer Interaction, ACM Transactions on Computer Human Interaction, and Informatica. He has advised a number of companies started by his students, including Google. In 2011 he received the ACM SIGCHI Lifetime Research Award.
Marlene Helen Kennedy Wolfe
Postdoctoral Research Fellow, Civil and Environmental Engineering
Bio Marlene is a Postdoctoral Scholar with the Woods Institute for the Environment. Her research uses environmental engineering, microbiology, and epidemiology to address complex issues in WASH and child health. She has 10 years of experience working on WASH topics in low and middle income countries and emergencies, especially in East Africa. During her PhD, she focused on the development of new approaches to assess exposure to emerging infectious challenges and interventions to interrupt transmission with a focus on handwashing. At Stanford, Marlene focuses on the relationship between WASH infrastructure in communities and institutions and disease risk in the local environment. Marlene did her doctoral training in Environmental Health at Tufts University, and holds an MSc in Epidemiology from the the London School of Hygiene and Tropical Medicine and a BA in Human Biology from Stanford University.
Wing Hung Wong
Stephen R. Pierce Family Goldman Sachs Professor in Science and Human Health and Professor of Biomedical Data Science
Current Research and Scholarly Interests Current interest centers on the application of statistics to biology and medicine. We are particularly interested in questions concerning gene regulation, genome interpretation and their applications to precision medicine.
Edward H. Wood, MD
Assistant Professor of Ophthalmology at the Stanford University Medical Center
Current Research and Scholarly Interests http://med.stanford.edu/woodlab.html
Edward H. Wood, MD is an assistant professor of ophthalmology practicing adult and pediatric vitreoretinal surgery at Stanford University School of Medicine. Dr. Wood engages in translational research with the goal of developing new therapies and approaches for patients without viable treatment options. He does so through leveraging the technologies of patient derived stem cells, optogenetics, and phenotypic drug screening in conjunction with active clinical research and surgical device development. Dr. Wood has filed numerous patents and founded several healthcare startups with the goal of improving patients? quality of life. His research interests include regenerative medicine, drug discovery, and pediatric retinal disease with the ultimate goal of pursuing basic science discoveries with potential for impactful clinical translation. His research interests are significantly inspired by his patients, and he is driven towards not only delivering the highest quality of care currently available, but also in developing the future standard of care in the field of medical retina and vitreoretinal surgery.
Postdoctoral Research Fellow, Ophthalmology
Current Research and Scholarly Interests Many types of blindness result from the neurons of the retina no longer being able to communicate with the brain due to injury or disease. In mammals, the adult retina cannot make new retinal ganglion cells (the neurons that connect the retina with the brain) to replace those that are lost. In my work, I aim to learn about normal development of retinal ganglion cells and, further, to regenerate new retinal ganglion cells if they are lost in adulthood.
John Fraser Wright
Professor (Research) of Pediatrics (Stem Cell Transplantation)
Bio J Fraser Wright, PhD
Dr. Wright received his PhD in 1989 from the University of Toronto (Biochemistry) for studies
characterizing the interaction of complement with IgM, and completed post-doctoral studies at INSERM
/ CENG Grenoble, France in molecular immunology focused on antigen processing and presentation. He
was awarded a CRCS/ MRC Scholarship, gaining faculty appointment at the University of Toronto. In
1996 he joined industry as a Scientist at Pasteur Sanofi, contributing there to the development of
vaccines and cancer immunotherapies, and subsequently as Director of Development and Clinical
Manufacturing at Avigen, a gene therapy company that pioneered AAV-based investigational gene
therapies for hemophilia and Parkinson?s disease. In 2004 he returned to academia, establishing and
directing the Clinical Vector Facility at the Center for Cellular and Molecular Therapeutics at Children?s
Hospital of Philadelphia, and gaining faculty appointment at the University of Pennsylvania Perelman
School of Medicine as professor of Pathology and Laboratory Medicine. Dr. Wright has contributed to
several clinical development programs in gene therapy, including for Luxturna and Kymriah, the first
gene therapies for a genetic (RPE65 deficiency) and non-genetic (CAR-T immunotherapy) disease,
respectively, approved in the United States, and for the first gene therapy clinical trial that delivered an
AAV-vectorized monoclonal antibody to human subjects for HIV passive immunity. He is a Co-founder of
Spark Therapeutics, serving there and subsequently at Axovant as Chief Technology Officer. In 2019 Dr.
Wright joined Stanford University as Professor of Pediatrics at The Center for Definitive and Curative
Medicine (CDCM). His research program aims to address key immunological barriers to gene therapy
through innovative approaches to viral vector design and generation, and to develop vectorized
antibodies for serious human diseases.
Albert Y. Wu, MD, PhD, FACS
Assistant Professor of Ophthalmology at the Stanford University Medical Center
Current Research and Scholarly Interests My translational research focuses on using autologous stem cells to recreate a patient?s ocular tissues for potential transplantation. We are generating tissue from induced pluripotent stem cells to treat limbal stem cell deficiency in patients who are bilaterally blind. By applying my background in molecular and cellular biology, stem cell biology, oculoplastic surgery, I hope to make regenerative medicine a reality for those suffering from orbital and ocular disease.
Chien Ting Wu
Postdoctoral Research Fellow, Microbiology and Immunology
Bio I started conducting research as a second-year student in college. I entered a biochemical lab to perform research and had my own project. My topic was Alzheimer's disease, and I focused on the relationship between aggregated amyloid-beta and reactive oxygen species levels in cells. I am very grateful for this particular research experience because it allowed me to realize that I am particularly interested in studying disease-associated proteins on a molecular level. Thus, these early research experiences have been invaluable in shaping my scientific interests and personality.
I decided to pursue my graduate training straight out of college by obtaining my master?s degree. I then decided to join the Chen, I-T. Lab for my graduate research training, where I discovered that a novel recombinant protein, LZ8 cloned from Ganoderma, can inhibit the duplication of cancer cells in vitro and decrease the growth rate of tumors in vivo through regulating the p53/MDM2/mTOR signaling pathway. My findings were published in the journal Carcinogenesis. This was my first first-author paper. During this time, I learned how to become an independent scientist.
After my master?s degree, I spent three years completing my military service as a research assistant in Academia Sinica. I worked under the supervision of Prof. Tang Tang. My research focused on the molecular mechanism of centriole duplication. In my research, I found that CEP120, a ciliopathy protein, is required to promote centriole elongation. Overexpression of CEP120 can induce overly long centrioles. This work was published in the Journal of Cell Biology. This was my second first-author paper. Because of these valuable lab experiences, I began to be fascinated by the centriole and cilium field.
Afterwards, to better understand centriole- and cilia-related human hereditary diseases, I worked as a molecular diagnostician in a molecular diagnosis lab at Oregon Health Science University. I used next-generation sequencing (NGS) to identify gene mutations from ciliopathy patients. During this period, I learned how to run a complete molecular diagnosis, draw blood for running NGS, analyzing patient data, preparing patient reports and designing a novel disease panel to run NGS. This experience provided me with a new perspective and connected the things that I learned in the centriole and cilia field, from biochemistry to molecular biology to clinical diagnosis. Most importantly, this experience allowed me to realize that so many people suffer from ciliopathy disease. As a researcher, I hope to continue my research on the cilium field to help develop better clinical treatments for these patients.
For this reason, I decided to join the Tang Tang Lab in Academia Sinica for my PhD training. The Tang Lab has a longstanding interest in understanding the mechanisms of centriole duplication and is at the forefront of research in the primary cilium field. In this period, I found that Myosin-Va, a motor protein, is required for preciliary vesicle trafficking during the early stage of ciliogenesis. This research was published in Nature Cell Biology.
Thus, my experiences have allowed me to develop my scientific interests and to realize that I would one day like to run my own laboratory and research program focusing on cilium-related diseases.
Current Research and Scholarly Interests I am interested in how the brain matures to control the bladder and external sphincter to achieve urinary continence. Using functional MRI of the brain, we are investigating if certain patterns of activity will predict which children will respond to therapy for incontinence.
Joseph C. Wu
Director, Stanford Cardiovascular Institute, Simon H. Stertzer, MD, Professor and Professor of Radiology
Current Research and Scholarly Interests Drug discovery, drug screening, and disease modeling using biobank of cardiac iPSC lines.
Associate Professor of Medicine (Endocrinology)
Current Research and Scholarly Interests My laboratory focuses on the pathways that regulate the differentiation of mesenchymal stem cells into the osteoblast and adipocyte lineages. We are also studying the role of osteoblasts in the hematopoietic and cancer niches in the bone marrow microenvironment.
Sean M. Wu
Associate Professor of Medicine (Cardiovascular Medicine) and, by courtesy, of Pediatrics
Current Research and Scholarly Interests My lab seeks to identify mechanisms regulating cardiac lineage commitment during embryonic development and the biology of cardiac progenitor cells in development and disease. We believe that by understanding the transcriptional and epigenetic basis of cardiomyocyte growth and differentiation, we can identify the most effective ways to repair diseased adult hearts. We employ mouse and human embryonic and induced pluripotent stem cells as well as rodents as our in vivo models for investigation.
Courtney Wusthoff, MD
Associate Professor of Neurology and, by courtesy, of Pediatrics (Neonatology) at the Stanford University Medical Center
Current Research and Scholarly Interests My projects focus on clinical research in newborns with, or at risk, for brain injury. I use EEG in at-risk neonates to better understand the underlying pathophysiology of risk factors that may lead to worse outcomes. I am particularly interested in neonatal seizures and how they may exacerbate perinatal brain injury with a goal to identify treatments that might protect the vulnerable brain. I am also interested in EEG in other pediatric populations, as well as medical ethics and global health.
Tony Wyss-Coray, PhD
D. H. Chen Professor II
Current Research and Scholarly Interests Use of genetic and molecular tools to dissect immune and inflammatory pathways in Alzheimer's and neurodegeneration.